Subject(s)
Alveolar Ridge Augmentation/methods , Anodontia/rehabilitation , Dental Implantation, Endosseous/methods , Dental Prosthesis, Implant-Supported , Malocclusion, Angle Class III/surgery , Adolescent , Anodontia/complications , Bone Transplantation , Humans , Male , Malocclusion, Angle Class III/complications , Osteotomy, Le FortABSTRACT
Our aim was to conduct an epidemiological study in order to better assess the frequency of maxillo-facial sport injuries. Only those activities that are practised within a sport or game association are included in the study. A standard letter was sent to all French sport and game associations (Olympic or not) as well as to some major insurance companies (73 sport and game associations and 11 insurance companies). However the scope of the study rapidly proved limited since over the two-month period considered only 16 sport associations and one insurance company returned an answer. The exploitable results are presented and a brief overview of the recent relevant international studies is given.
Subject(s)
Athletic Injuries/epidemiology , Maxillofacial Injuries/epidemiology , Adult , Data Collection , Feasibility Studies , France/epidemiology , Humans , Maxillofacial Injuries/etiologyABSTRACT
SCID-hu mouse models are of interest in the pathologic investigation of HIV infection, but obtaining a T cell response in SCID-hu-PBL mice is still controversial. We have developed a SCID model by engrafting human skin and autologous PBLs from HIV-seronegative individuals. The study describes the ability of this human-mouse chimera to generate in vivo a primary T lymphocyte response against HIV Ag. The injection of human autologous PBLs was performed 4 to 5 wk after the skin engraftment. Two weeks after injection of PBLs, chimeric mice were immunized with recombinant canary pox virus expressing HIV-1 LAIgp160 (vCP-LAIgp160) and supplemented or not with rIL-2. Intradermal vCP-LAIgp160 injection induced an intradermal perivascular human lymphocytic infiltrate and an epidermic network of CD1a+, CD80+, and CD86+ cells. We derived CD4+ T cell lines (STLs) from the human skin graft of immunized mice, showing that STLs mediated an MHC class II-restricted cytolytic activity directed against HIV-LAIgp160 Ags. Cytokine gene expression in both human skin cells and in STLs showed a predominance of IL-2, IFN-gamma, and IL-12 transcripts. Finally, the T cell repertoire analysis using the immunoscope technique showed a very limited CDR3 length polymorphism in the skin infiltrating lymphocytes suggesting an Ag-specific repertoire. The ability to induce a primary Th1 cell response in vivo affords a useful preclinical model for testing vaccine strategies.
Subject(s)
Adoptive Transfer/methods , HIV Envelope Protein gp160/immunology , Lymphocyte Transfusion , Skin Transplantation/immunology , Th1 Cells/transplantation , Animals , Antigens, CD1/analysis , Antigens, Viral/immunology , Avipoxvirus/genetics , Avipoxvirus/immunology , Cell Line , Cell Movement/immunology , Chimera/immunology , Cytokines/biosynthesis , Cytokines/genetics , Epitopes, T-Lymphocyte/immunology , Gene Rearrangement, beta-Chain T-Cell Antigen Receptor , HIV Envelope Protein gp160/genetics , HIV-1/genetics , HIV-1/immunology , Humans , Injections, Intradermal , Langerhans Cells/immunology , Leukocytes/pathology , Mice , Mice, SCID , Recombinant Fusion Proteins/administration & dosage , Recombinant Fusion Proteins/immunology , Skin/immunology , Skin/metabolism , Skin/pathology , Skin Transplantation/methods , Skin Transplantation/pathology , T-Lymphocytes/cytology , T-Lymphocytes/metabolism , T-Lymphocytes/pathology , Th1 Cells/immunology , Th1 Cells/metabolismABSTRACT
The use of biomaterials for bone reconstruction raises the problem of their architectural and structural outcome. CT makes an accurate biometric follow-up possible. The association of HA, collagen and GAG appears to be a reliable substitute for bone, owing to the permanence of the dimensional results and to the structural evolution that seems to finally provide total structural restoration.
Subject(s)
Biocompatible Materials , Collagen , Glycosaminoglycans , Hydroxyapatites , Mandible/diagnostic imaging , Mandible/surgery , Prostheses and Implants , Tomography, X-Ray Computed , Animals , Bone Transplantation , Ceramics , Cnidaria , Durapatite , Focal Infection, Dental/surgery , Follow-Up Studies , Humans , Mandible/pathology , Mandibular Diseases/surgery , Mandibular Injuries/surgery , Transplantation, Heterologous , Wound HealingABSTRACT
Treatment of orbito-malar trauma has two priorities; restoration of the pelvi-orbital integrity and recovery of malar stability. Numerous techniques using various materials, whether or not of autologous origin, have been developed with this aim in mind. The authors report their experience with the PDS bioresorbable orbital prosthesis within the framework of orbito-malar trauma.
Subject(s)
Orbital Fractures/surgery , Polyesters , Prostheses and Implants , Skull Fractures/surgery , Zygomatic Fractures/surgery , Biocompatible Materials , Humans , Orbit/surgery , Polydioxanone , Postoperative Complications , Zygoma/surgeryABSTRACT
External fixation devices have relatively little application in stomatology, but they are indispensable in certain situations. Equipment presently available for use by maxillofacial surgeons is relatively reduced in number, and two new fixation devices are proposed : a Jacquet type miniaturized fixation device and one of the Sorem type particularly adapted for the mandible.
