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AIDS Care ; 36(6): 816-831, 2024 06.
Article in English | MEDLINE | ID: mdl-38422450

ABSTRACT

We conducted a parallel-group randomized controlled trial in three HIV clinics in Mexico to evaluate a user-centred habit-formation intervention to improve ART adherence among MSM living with HIV. We randomized 74 participants to the intervention group and 77 to the control group. We measured adherence at one, four, and ten months through medication possession ratio and self-reported adherence. Additionally, we measured viral load, CD4 cell count, major depression disorder symptoms, and alcohol and substance use disorder at baseline, fourth and tenth months. We found no statistically significant effect on adherence between groups. However, the intervention demonstrated positive results in major depression disorder symptoms (21% vs. 6%, p = 0.008) and substance use disorder (11% vs. 1%, p = 0.018) in the fourth month. The latter is relevant because, in addition to its direct benefit, it might also improve the chances of maintaining adequate adherence in the long term. This trial was retrospectively registered at ClinicalTrials.gov (trial number NCT03410680) on 8 January 2018.Trial registration: ClinicalTrials.gov identifier: NCT03410680.


Subject(s)
Anti-HIV Agents , HIV Infections , Homosexuality, Male , Medication Adherence , Viral Load , Humans , Male , Mexico , HIV Infections/drug therapy , HIV Infections/psychology , Adult , Homosexuality, Male/psychology , Medication Adherence/statistics & numerical data , Medication Adherence/psychology , Anti-HIV Agents/therapeutic use , Middle Aged , Substance-Related Disorders , CD4 Lymphocyte Count , Depressive Disorder, Major/drug therapy
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