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1.
Ugeskr Laeger ; 184(39)2022 09 26.
Article in Danish | MEDLINE | ID: mdl-36205161

ABSTRACT

This is a case report of a 48-year-old female with no medical conditions, with a one-day history of diplopia, mild headache, vertigo and generalized paraesthesia. The neurological examination revealed ophthalmoplegia, ataxia and areflexia leading to a diagnosis of Miller Fisher syndrome, a rare variant of Guillain-Barré syndrome. This highlights the importance of considering the rarer variants of Guillain-Barré syndrome in the differential diagnosis of patients who present with this triad.


Subject(s)
Guillain-Barre Syndrome , Miller Fisher Syndrome , Ophthalmoplegia , Diagnosis, Differential , Female , Guillain-Barre Syndrome/diagnosis , Headache/diagnosis , Headache/etiology , Humans , Middle Aged , Miller Fisher Syndrome/complications , Miller Fisher Syndrome/diagnosis , Miller Fisher Syndrome/therapy , Ophthalmoplegia/diagnosis , Ophthalmoplegia/etiology
2.
Sci Rep ; 10(1): 7796, 2020 05 08.
Article in English | MEDLINE | ID: mdl-32385297

ABSTRACT

In Europe, Lyme neuroborreliosis (LNB) is the most severe manifestation of Lyme borreliosis and has recently been added to the communicable disease surveillance list for EU/EEA by the European Commission. In Northern Europe, LNB is primarily caused by the spirochete Borrelia garinii and transmitted by the tick Ixodes ricinus. This Danish observational epidemiologic case-control study includes every identified LNB patient (n = 401) on Funen, Denmark, from 1995-2014. We display spatial and temporal LNB incidence variation, seasonal distribution of cases and local spatial case clustering. Seasonal patterns show LNB symptom-onset peaking in July and a significant seasonal difference in number of cases (p < 0.01). We found no significant change in seasonality patterns over time when dividing the study period into 5-year intervals. We identified a significant local geographical hot-spot of cases with a relative risk of 2.44 (p = 0.013). Analysis revealed a significantly shorter distance to nearest forest for cases compared with controls (p < 0.001). We present a novel map of the focal geographical distribution of LNB cases in a high endemic borreliosis area. Continued studies of case clustering in the epidemiology of LNB are of key importance in guiding intervention strategies.


Subject(s)
Borrelia burgdorferi , Lyme Neuroborreliosis/epidemiology , Lyme Neuroborreliosis/microbiology , Cluster Analysis , Denmark/epidemiology , Geography, Medical , History, 21st Century , Humans , Incidence , Lyme Neuroborreliosis/history , Public Health Surveillance , Seasons , Spatio-Temporal Analysis
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