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Bioorg Med Chem Lett
; 14(15): 3897-900, 2004 Aug 02.
Article
in English
| MEDLINE
| ID: mdl-15225693
ABSTRACT
19-mer oligonucleotides with oleylamine tethered at 3' and 5' terminal, respectively, were incorporated into unilamellar liposomes of dioleoylphosphatidylcholine (DOPC). Addition of complementary nucleotide resulted in hybridization with oligonucleotides located on different liposomes and caused liposome aggregation. Significant changes of sound velocimetry and turbidity were readily observed at 10 nM concentration of the complementary chain.