ABSTRACT
Patients with FC II-IV CHD and angina of effort were divided into 3 groups (compensated, subcompensated, and decompensated types) based on vascular reaction to local ischemic load Serum lipid spectrum, parameters of hemostasis and blood flow were evaluated before and after the load. It was shown that each type of vascular reaction had specific predictors. Vasodilation in "compensated" patients was largely due to hydrodynamic changes in the vascular bed. The "subcompensated" type was characterized by reduced sensitivity to this changes "decompensated" type of reactivity was related to metabolic rather than hydrodynamic disorders accounting for paradoxic vasoconstriction in response to ischemic load.
Subject(s)
Blood Flow Velocity/physiology , Brachial Artery/physiopathology , Coronary Disease/physiopathology , Endothelium, Vascular/physiopathology , Vasodilation/physiology , Brachial Artery/diagnostic imaging , Coronary Disease/diagnosis , Follow-Up Studies , Humans , Middle Aged , Prognosis , Severity of Illness Index , Ultrasonography, DopplerABSTRACT
Hemostatic parameters and the diameter of the brachial artery were studied in patients with functional classes II and III angina on exertion before and after an ischemic test. A multivariate statistical analysis was used to determine the significant parameters that distinguish vascular endothelial function in these patients. At the same time it was established that endothelial dysfunction in patients with varying angina pectoris is determined by different predictors of thrombocytic-vascular hemostasis.
