ABSTRACT
The present work deals with results of intensive therapy and temporary organ substitution by using hemoperfusion through a suspension of living donor hepatocytes in 71 patients with acute hepatic insufficiency. Hemoperfusion was performed through a suspension of fresh living hepatocytes or through a suspension of cryo-conserved (during 60 days) living hepatocytes. Lethality was 37-42%.
Subject(s)
Hemoperfusion/methods , Liver Failure, Acute/therapy , Liver/cytology , Animals , Cryopreservation , Evaluation Studies as Topic , Hemoperfusion/adverse effects , Humans , Remission Induction , Swine , Tissue PreservationSubject(s)
Disease Models, Animal , Hemoperfusion/methods , Sepsis/therapy , Spleen , Staphylococcal Infections/therapy , Surgical Wound Infection/therapy , Animals , Dogs , Humans , Male , Middle Aged , SuspensionsABSTRACT
The results of intensive therapy and temporary organ substitution by hemoperfusion through a suspension of active hepatocytes in 126 patients suffering from acute hepatic insufficiency (AHI) induced by virus B hepatitis, virus non-A, non-B hepatitis, acute toxic hepatitis, active liver cirrhosis, sepsis leptospirosis long-term subhepatic jaundice are presented in this paper. Hepatic encephalopathia confirmed both clinically and electroencephalographically was registered in all the patients. The patients were subdivided into two groups: a complex of commonly used curative measures according to the intensive therapy for AHI was applied in Group A (67 patients); in Group B (59 patients), alongside with the above measures, temporary organ substitution by hemoperfusion through a suspension of active porky hepatocytes was also performed. The lethality in Group A made up 59% and that in Group B was 37%.
Subject(s)
Critical Care/methods , Hemoperfusion/methods , Hepatic Encephalopathy/therapy , Liver/cytology , Adult , Aged , Aged, 80 and over , Electroencephalography , Humans , Middle AgedSubject(s)
Hemoperfusion , Liver Diseases/therapy , Adult , Aged , Female , Humans , Male , Middle AgedSubject(s)
Hemoperfusion , Liver Diseases/therapy , Adult , Aged , Female , Humans , Male , Middle AgedSubject(s)
Charcoal/therapeutic use , Liver Diseases/therapy , Animals , Dogs , Evaluation Studies as Topic , Hemoperfusion , Time FactorsSubject(s)
Cholestasis/therapy , Hemoperfusion , Female , Hemoperfusion/methods , Humans , Middle Aged , Preoperative CareSubject(s)
Bile Acids and Salts/blood , Cholestasis/therapy , Hemoperfusion , Adult , Aged , Female , Humans , Male , Middle AgedSubject(s)
Assisted Circulation , Intra-Aortic Balloon Pumping , Poisoning/therapy , Acute Disease , Adult , Aged , Assisted Circulation/adverse effects , Cardiovascular Diseases/chemically induced , Cardiovascular Diseases/therapy , Diuresis , Female , Hemodynamics , Humans , Intra-Aortic Balloon Pumping/adverse effects , Male , Middle Aged , Poisoning/complications , Time FactorsSubject(s)
Assisted Circulation , Poisoning/therapy , Adult , Aged , Barbiturates/poisoning , Diuresis , Female , Heart Failure/chemically induced , Heart Failure/therapy , Hemodynamics , Humans , Male , Middle Aged , Tranquilizing Agents/poisoningSubject(s)
Liver Transplantation , Organ Preservation/methods , Tissue Preservation/methods , Animals , DogsSubject(s)
Liver/physiopathology , Parenteral Nutrition, Total , Parenteral Nutrition , Acid-Base Imbalance/etiology , Acid-Base Imbalance/therapy , Animals , Blood Proteins/metabolism , Dogs , Hepatectomy , Liver Function Tests , Liver Transplantation , Nitrogen/blood , Water-Electrolyte Imbalance/etiology , Water-Electrolyte Imbalance/therapySubject(s)
Exchange Transfusion, Whole Blood , Liver Diseases/therapy , Acute Disease , Animals , Dogs , Female , MaleABSTRACT
The functional activity of the transplanted (additional) liver and its efficiency in the treatment of critical hepatic insufficiency was studied in experiments on dogs. Without an immunosuppression being used the additionally transplanted liver manifests its functional activity in the recipient's organism within 4 days and is able to support the animal's life for 3-4 days.
Subject(s)
Liver Diseases/surgery , Liver Transplantation , Acute Disease , Animals , Dogs , Female , Male , Transplantation, HomologousABSTRACT
The method of haemoperfusion through the ion exchange resin and active carbon was used 15 times in 13 patients with heavy forms of mechanical subhepatogenous jaundice. The haemoperfusion was used as a method of preoperative preparation for reduction of hyperbilirubinemia and cholemic intoxication and for prevention of possible postoperative complications. One patient recovered. One patient died of progressing hepatic insufficiency. The rest of the patients were subjected to surgical interventions for the main disease.
