ABSTRACT
Changes in magnetic resonance imaging (MRI) during neoadjuvant chemotherapy (NAC) have been reported as predictive of pathology outcome in triple-negative and HER2-positive breast cancer. The purpose of our study was to evaluate the relevance of breast cancer subtype for MRI response in 24 women before and during NAC in our centre. Our results show that a reduction greater than 23% is associated with a pathological complete response (pCR) in Her-2-positive and ER-negative/Her2-negative breast cancer, and suggest a trend correlation between higher ADC values and pCR in these subtypes in comparison with ER-positive/Her2-negative breast cancers. Higher proliferating tumours respond better to chemotherapy and our study suggests that changes in MRI during NAC are predictive of pCR in these breast cancer subtypes.
Subject(s)
Breast Neoplasms/drug therapy , Female , Humans , Magnetic Resonance Imaging , Neoadjuvant Therapy , Neoplasm Staging , Receptor, ErbB-2/metabolismABSTRACT
Ten commercial composts were evaluated on the basis of chemical, physical and biological characteristics and compared with a compost produced by a safe matrix in controlled conditions. FT-IR spectra, (13)C CP-MAS NMR spectra and molecular weights were also assayed on humic acids extracted from the composts. The results show that the origin of the starting materials affects the quality of the end products especially for their heavy metal content and genotoxic effect. The presence of a high percentage of low molecular weight fractions generally recorded in the humic acids from commercial composts could be due to uncorrected composting process. FT-IR and (13)C CP-MAS NMR spectra agree with functional group assignments, characterising the level of humification. The results show that commercial composts can display harmful properties probably due to the origin of the starting material, therefore a regulation about both compost production and characterisation should be suitable.
Subject(s)
Humic Substances/analysis , Metals, Heavy/analysis , Refuse Disposal , DNA Damage , Magnetic Resonance Spectroscopy , Metals, Heavy/adverse effects , Molecular Weight , Mutagenicity Tests , Risk Assessment , Spectroscopy, Fourier Transform Infrared , ViciaABSTRACT
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