QTc prolongation in cannabis hyperemesis syndrome patients exposed to antiemetics: A retrospective chart review.

OBJECTIVE: To evaluate the risk of QT prolongation in patients treated for Cannabis Hyperemesis Syndrome (CHS) in the emergency department. METHODS: This was a retrospective comprehensive chart review of patients in the University of Colorado Health Emergency Department. Charts were identified by ICD9/10 codes from January 1, 2012 to December 31, 2014 for cannabis use and data were manually abstracted. We performed chi-square and odds ratios, stratified by drug, to determine differences in medication induced QTc prolongation and performed logistic regression to predict prolongation greater than 500 ms. We captured adverse events from medications as a secondary outcome. RESULTS: We found 282 cases of CHS during the study period. There were no significant differences between the median post-medication QTc value stratified by drug when all medications were analyzed simultaneously. A multiple logistic regression model showed that only a potassium below 3.0 mmol/L predicted QT prolongation greater than 500 msec. CONCLUSION: Anti-emetics used to treat CHS did not result in significant QTC prolongation in this cohort.

Specialized interferon ligand action in COVID19

The impacts of IFN signaling on COVID19 pathology are multiple, with protective and harmful effects being documented. We report here a multi-omics investigation of IFN signaling in hospitalized COVID19 patients, defining the biosignatures associated with varying levels of 12 different IFN ligands. Previously we showed that seroconversion associates with decreased production of select IFN ligands (Galbraith et al, 2021). We show now that the antiviral transcriptional response in circulating immune cells is strongly associated with a specific subset of ligands, most prominently IFNA2 and IFNG. In contrast, proteomics signatures indicative of endothelial damage associate with levels of IFNB and IFNA6. Differential IFN ligand production is linked to distinct constellations of circulating immune cells. Lastly, IFN ligands associate differentially with activation of the kynurenine pathway, dysregulated fatty acid metabolism, and altered central carbon metabolism. Altogether, these results reveal specialized IFN ligand action in COVID19, with potential diagnostic and therapeutic implications. IMPACT STATEMENTAnalysis of multi-omics signatures associated with 12 different IFN ligands reveals their specialized action in COVID19.