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1.
J Zoo Wildl Med ; 48(2): 549-553, 2017 Jun.
Article in English | MEDLINE | ID: mdl-28749293

ABSTRACT

A female North American porcupine ( Erethizon dorsatum ) was evaluated for a unilateral pedal crusting and alopecic dermatopathy. Fungal culture and histopathology testing revealed Microsporum gypseum dermatophytosis. Treatment with topical miconazole was initiated and then discontinued after 9 days and changed to oral terbinafine. Twenty-eight days after initial examination, clinical signs were improving, and fungal cultures of the front foot, muzzle, and noninfected area along the dorsum were negative for M. gypseum. Visual exams were conducted on a regular basis. Eighty-three days after initial evaluation, clinical signs had completely resolved and repeat fungal cultures were negative. One of the animal's keepers was suspected to have acquired a dermal fungal infection 3 days after contact with this porcupine, and lesions had resolved after treatment with topical ketoconazole. To the authors' knowledge, this is the first report of M. gypseum diagnosed and treated in a captive North American porcupine. Veterinary staff and zookeepers should be aware of this potentially zoonotic infection.


Subject(s)
Animals, Zoo , Porcupines , Tinea/veterinary , Zoonoses , Administration, Oral , Administration, Topical , Animals , Antifungal Agents/administration & dosage , Antifungal Agents/therapeutic use , Female , Humans , Miconazole/administration & dosage , Miconazole/therapeutic use , Naphthalenes/administration & dosage , Naphthalenes/therapeutic use , Terbinafine , Tinea/diagnosis , Tinea/microbiology
2.
J Avian Med Surg ; 30(2): 165-71, 2016 Jun.
Article in English | MEDLINE | ID: mdl-27315385

ABSTRACT

A 20-year-old, female African grey parrot ( Psittacus erithacus erithacus) was examined because of ataxia and weakness. Radiographs were unremarkable, and results of a complete blood cell count revealed leukocytosis and heterophilia. Because of poor response to therapy with meloxicam, doxycycline, and enrofloxacin; deteriorating condition; and poor prognosis, the parrot was euthanatized. Postmortem examination revealed 2 dark red nodules in the liver. No grossly visible mass was observed in the syrinx. Histologic examination of the liver and syrinx revealed similar foci of round, oval, and polygonal cells exhibiting severe pleomorphism, with poorly demarcated cytoplasmic borders and moderate amounts of eosinophilic cytoplasm containing brown to black granules (melanin). The mitotic index was 15. The presence of melanin pigment is consistent with a diagnosis of melanoma at both sites. The multifocal distribution and intravascular invasion indicate metastasis; however, the site of origin was unknown. To our knowledge, this is the first recorded case of melanoma in an avian syrinx.


Subject(s)
Bird Diseases/pathology , Liver Neoplasms/veterinary , Melanoma/veterinary , Parrots , Tracheal Diseases/veterinary , Animals , Female , Liver Neoplasms/pathology , Tracheal Diseases/pathology
3.
J Zoo Wildl Med ; 46(3): 596-600, 2015 Sep.
Article in English | MEDLINE | ID: mdl-26352968

ABSTRACT

A 7-yr-old, intact, female swift fox (Vulpes velox) presented to the Veterinary Health Center at Kansas State University with a history of chronic weight loss, lethargy, inappetence, and myiasis. On physical examination, a firm mass was palpated in the mid- to cranial abdomen. The fox was euthanatized as a result of the grave prognosis. Gross necropsy and histologic findings included a small intestinal adenocarcinoma with diffuse transperitoneal spread throughout the abdominal cavity (carcinomatosis). To the authors' knowledge, this is the first report of intestinal adenocarcinoma with carcinomatosis in a swift fox.


Subject(s)
Adenocarcinoma/veterinary , Foxes , Intestinal Neoplasms/veterinary , Adenocarcinoma/diagnosis , Adenocarcinoma/pathology , Animals , Animals, Zoo , Female , Intestinal Neoplasms/diagnosis , Intestinal Neoplasms/pathology
4.
J Am Vet Med Assoc ; 246(6): 674-80, 2015 Mar 15.
Article in English | MEDLINE | ID: mdl-25719850

ABSTRACT

CASE DESCRIPTION: An approximately 5-year-old sexually intact male alpaca was evaluated because of a right-sided maxillary mass that had recurred after previous surgical debulking. CLINICAL FINDINGS: Clinical, radiographic, and CT examination revealed an approximately 1.5-cm-diameter soft tissue mass associated with expansile osteolysis of the maxillary alveolar bone, beginning at the level of the right maxillary third premolar tooth extending caudally to the level of the rostral roots of the second molar tooth. TREATMENT AND OUTCOME: Right partial maxillectomy was performed, and histologic examination revealed an incompletely excised fibrosarcoma with osseous metaplasia. External beam radiation therapy to the tumor bed was initiated 1 month after surgery. Computerized planning was performed, and a total radiation dose of 48 Gy was prescribed in eleven 4.4-Gy fractions. Follow-up CT evaluations 6 and 58 weeks after radiation therapy was completed revealed no evidence of tumor recurrence. No clinical evidence of tumor recurrence was detected through 110 weeks after radiation therapy. CLINICAL RELEVANCE: The oral fibrosarcoma in the alpaca described here was successfully treated with surgical excision and adjuvant radiation therapy, resulting in excellent quality of life of the treated animal.


Subject(s)
Camelids, New World , Fibrosarcoma/veterinary , Maxillary Neoplasms/veterinary , Animals , Fibrosarcoma/diagnosis , Fibrosarcoma/radiotherapy , Male , Maxillary Neoplasms/diagnosis , Maxillary Neoplasms/radiotherapy
5.
Comp Med ; 62(6): 508-15, 2012 Dec.
Article in English | MEDLINE | ID: mdl-23561885

ABSTRACT

Bottlenose dolphins can have iron overload (that is, hemochromatosis), and managed populations of dolphins may be more susceptible to this disease than are wild dolphins. Serum iron, total iron-binding capacity (TIBC), transferrin saturation, and ferritin were measured in 181 samples from 141 dolphins in 2 managed collections and 2 free-ranging populations. Although no iron indices increased with age among free-ranging dolphins, ferritin increased with age in managed collections. Dolphins from managed collections had higher iron, ferritin, and transferrin saturation values than did free-ranging dolphins. Dolphins with high serum iron (exceeding 300 µg/dL) were more likely to have elevated ferritin but not ceruloplasmin or haptoglobin, demonstrating that high serum levels of iron are due to a true increase in total body iron. A time-series study of 4 dolphins with hemochromatosis that were treated with phlebotomy demonstrated significant decreases in serum ferritin, iron, and TIBC between pre- and posttreatment samples; transferrin saturation initially fell but returned to prephlebotomy levels by 6 mo after treatment. Compared with those in managed collections, wild dolphins were 15 times more likely to have low serum iron (100 µg/dL or less), and this measure was associated with lower haptoglobin. In conclusion, bottlenose dolphins in managed collections are more likely to have greater iron stores than are free-ranging dolphins. Determining why this situation occurs among some dolphin populations and not others may improve the treatment of hemochromatosis in dolphins and provide clues to causes of nonhereditary hemochromatosis in humans.


Subject(s)
Animals, Wild/blood , Animals, Zoo/blood , Bottle-Nosed Dolphin/blood , Hemochromatosis/veterinary , Iron-Binding Proteins/metabolism , Iron/blood , Transferrin/metabolism , Age Factors , Analysis of Variance , Animals , Electrophoresis, Polyacrylamide Gel/veterinary , Enzyme-Linked Immunosorbent Assay/veterinary , Ferritins/blood , Haptoglobins/analysis , Hemochromatosis/blood , Phlebotomy/veterinary , Spectrophotometry/veterinary
6.
J Vet Diagn Invest ; 23(3): 619-22, 2011 May.
Article in English | MEDLINE | ID: mdl-21908303

ABSTRACT

A 4-year 10-month-old, intact female dromedary camel had progressive left carpal joint swelling and lameness for 7 months. Radiographs showed multifocal lytic lesions in the carpal and proximal metacarpal bones. Surgical biopsy of the synovial capsule and carpal bones suggested neoplasia, and the camel was subsequently euthanized. At necropsy, a white to pale pink, firm, multilobulated, soft tissue mass was located on the palmar aspect of the left carpal joint. Two smaller masses were present on the dorsal aspect of the carpal joint. The masses infiltrated all the carpal bones and the proximal region of the metacarpal bone. The joint capsule was diffusely thickened. The articular surfaces of the carpal bones and the metacarpal bone were multifocally eroded. The lungs contained multiple, firm, raised, gray, randomly distributed nodules. The neoplastic cells stained positive for vimentin and S-100. Chondrosarcoma arising from around the carpal joint with infiltration of carpal and metacarpal bones, and pulmonary metastasis, was diagnosed based on the histopathological and immunohistochemical evaluation.


Subject(s)
Bone Neoplasms/veterinary , Camelus , Carpal Bones/pathology , Chondrosarcoma/veterinary , Metacarpal Bones/pathology , Animals , Bone Neoplasms/diagnosis , Bone Neoplasms/pathology , Carpal Joints/pathology , Chondrosarcoma/diagnosis , Chondrosarcoma/pathology , Female
7.
Am J Vet Res ; 71(8): 946-52, 2010 Aug.
Article in English | MEDLINE | ID: mdl-20673095

ABSTRACT

OBJECTIVE: To evaluate the use of serum biomarkers of cartilage and bone metabolism to predict the occurrence and severity of osteochondrosis (OC) lesions in the distal portion of the femur in growing swine. ANIMALS: 71 gilts. PROCEDURES: At an abattoir, serum samples for analysis of 10 biomarkers indicative of cartilage and bone metabolism were obtained prior to processing of the pigs. The distal portion of each pig's left femur was directly examined and cut into longitudinal sections to evaluate the number and severity of abnormalities on the external surface, articular cartilage, and growth plate. Each specimen was categorized as with (n = 56) or without (15) OC, and an overall OC severity score was assigned to affected pigs. Logistic and linear regression analyses were performed to predict odds of OC on the basis of biomarker concentrations and predict the severity of OC values in affected pigs, respectively. RESULTS: Compared with values in unaffected pigs, serum concentrations of C-propeptide of type II collagen (CPII) and cartilage oligomeric matrix protein were significantly increased and concentrations of carboxy-terminal telopeptide of type II collagen 3/4-length fragment (C2C) and pyridinoline cross-links were significantly decreased in affected pigs. A 2-fold increase in CPII concentration increased the odds of pigs having OC by a factor of 97 (95% confidence interval, 6 to infinity). Changes in serum C2C concentration accounted for 49% of the variation in overall OC severity score. CONCLUSIONS AND CLINICAL RELEVANCE: Assessment of serum biomarker concentrations may be useful in the diagnosis of OC and aid in reduction of lameness in swine herds.


Subject(s)
Biomarkers/blood , Femur/physiopathology , Osteochondrosis/veterinary , Swine Diseases/blood , Alkaline Phosphatase/blood , Animals , Bone Development/physiology , Cartilage/metabolism , Collagen/blood , Collagen/metabolism , Enzyme-Linked Immunosorbent Assay/methods , Enzyme-Linked Immunosorbent Assay/veterinary , Female , Osteochondrosis/blood , Osteochondrosis/physiopathology , Severity of Illness Index , Swine , Swine Diseases/physiopathology
8.
J Zoo Wildl Med ; 38(2): 201-16, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17679503

ABSTRACT

Complete physical examinations and biomedical sample collection were performed on 70 free-ranging ring-tailed lemurs (Lemur catta) from three different habitats in the Beza Mahfaly Special Reserve (BMSR), in southern Madagascar, to assess the impact of humans and habitat on lemur health. Lemurs were chemically immobilized with ketamine and diazepam administered via blow darts for concurrent biomedical, morphometric, and behavioral studies. Subsets of the animals had blood analyzed for hematology, serum chemistry, micronutrients, fat-soluble vitamins (vitamins A, D, and E), measures of iron metabolism, and polymerase chain reaction assays (PCR) for Toxoplasma gondii, Hemoplasma spp., Bartonella spp., Ehrlichia spp., Anaplasma phagocytophilum, and Neorickettsia risticii. Results were compared on the basis of gender and the habitats at the study site: reserve (intact gallery forest), degraded (human inhabited and altered), and marginal (dry didieracea forest with heavy grazing and tree cutting). Levels of vitamin D, triglycerides, and cholesterol, and measures of iron metabolism for BMSR lemurs were greater than those previously reported for a free-ranging lemur population (Tsimanampetsotsa Strict Nature Reserve, Madagascar) with less access to foods of anthropogenic origin. BMSR ring-tailed lemurs from a habitat with less water (marginal) had higher sodium (P = 0.051), chloride (P = 0.045), osmolality (P = 0.010), and amylase (P = 0.05) levels than lemurs from other BMSR habitats, suggesting that these lemurs were less hydrated. Vitamin D levels of male lemurs were higher (P = 0.011) than those of females at BMSR, possibly because of differences in sunning behavior or differential selection of food items. The biological significance is uncertain for other parameters with statistically significant differences. All samples tested (n = 20) were negative for the pathogens tested using PCR assays. Continued concurrent biomedical and ecological research is needed at BMSR to confirm these results and determine their association with population mortality and fecundity rates.


Subject(s)
Blood Chemical Analysis/veterinary , Lemur , Nutritional Status , Physical Examination/veterinary , Animals , Animals, Wild , Bacteria/isolation & purification , Conservation of Natural Resources , Female , Hematologic Tests/veterinary , Lemur/microbiology , Lemur/parasitology , Lemur/physiology , Madagascar , Male , Parasitic Diseases, Animal/epidemiology , Reference Values , Sex Factors
9.
J Zoo Wildl Med ; 36(4): 648-52, 2005 Dec.
Article in English | MEDLINE | ID: mdl-17312722

ABSTRACT

Lemurs in captivity progressively accumulate iron deposits in a variety of organs (hemosiderosis) including duodenum, liver, and spleen throughout their lives. When excessive, the toxic effects of intracellular iron on parenchymal cells, particularly the liver, can result in clinical disease and death. The pathogenesis of excessive iron storage in these species has been attributed to dietary factors related to diets commonly fed in captivity. Tissue iron stores can be directly estimated by tissue biopsy and histologic examination, or quantitated by chemical analysis of biopsy tissue, However, expense and risk associated with anesthesia and surgery prevent routine use of tissue biopsy to assess iron status. A noninvasive means of assessing total body iron stores is needed to monitor iron stores in lemurs to determine whether dietary modification is preventing excessive iron deposition, and to monitor potential therapies such as phlebotomy or chelation. Serum ferritin concentration correlates with tissue iron stores in humans, horses, calves, dogs, cats, and pigs. Serum ferritin is considered the best serum analyte to predict total body iron stores in these species and is more reliable than serum iron or total iron binding capacity, both of which may be affected by disorders unrelated to iron adequacy or excess including hypoproteinemia, chronic infection, hemolytic anemia, hypothyroidism, renal disease, and drug administration. We have developed an enzyme-linked immunosorbent assay to measure serum ferritin in lemurs. The assay uses polyclonal rabbit anti-human ferritin antibodies in a sandwich arrangement. Ferritin isolated from liver and spleen of a black and white ruffed lemur (Varecia variegata variegata) was used as a standard. Ferritin standards were linear from 0 to 50 microg/L. Recovery of purified ferritin from lemur serum varied from 95% to 110%. The within-assay variability was 4.5%, and the assay-to-assay variability for three different samples ranged from 10% to 17%. The assay also measures serum ferritin in several other lemur species.


Subject(s)
Enzyme-Linked Immunosorbent Assay/veterinary , Ferritins/blood , Iron/metabolism , Lemur/blood , Animals , Antibodies, Monoclonal , Enzyme-Linked Immunosorbent Assay/methods , Enzyme-Linked Immunosorbent Assay/standards , Health Status , Iron/toxicity , Lemur/metabolism , Liver/chemistry , Liver/metabolism , Reproducibility of Results , Sensitivity and Specificity , Species Specificity , Spleen/chemistry , Spleen/metabolism
10.
J Zoo Wildl Med ; 36(4): 653-60, 2005 Dec.
Article in English | MEDLINE | ID: mdl-17312723

ABSTRACT

Serum samples from 63 clinically normal captive black and white ruffed lemurs (Varecia variegata variegata) were analyzed to survey serum iron, total iron binding capacity, transferrin saturation, and serum ferritin levels. Data analysis showed no differences in these analytes attributable to sex, but significantly higher levels of serum iron, transferrin saturation, and serum ferritin in older animals. The survey data were examined in light of two black and white ruffed lemurs that were treated for iron overload with serial phlebotomies. Prior to therapy, both phlebotomized lemurs had excess hepatic iron deposition, but had serum iron, transferrin saturation, and serum ferritin below the upper limits observed in the survey animals, suggesting that some clinically normal animals included in the survey may have accumulated excess systemic iron. Serial phlebotomy therapy reduced serum iron, transferrin saturation, and serum ferritin in both animals. Three years after the conclusion of therapy in the one remaining case, serum iron and transferrin saturation have risen substantially, whereas serum ferritin has risen slightly. Serum iron, transferrin saturation, and serum ferritin may be useful predictors of systemic iron stores in this species, though the correlation between these parameters and systemic iron stores needs to be determined.


Subject(s)
Ferritins/blood , Iron/blood , Lemur/blood , Transferrin/metabolism , Age Factors , Animals , Animals, Zoo , Female , Hemochromatosis/therapy , Hemochromatosis/veterinary , Male , Phlebotomy/methods , Phlebotomy/veterinary , Sex Factors , Species Specificity
11.
J Zoo Wildl Med ; 36(3): 534-7, 2005 Sep.
Article in English | MEDLINE | ID: mdl-17312780

ABSTRACT

A 6-yr-old female leopard (Panthera pardus) was evaluated for a history of chronic obstipation of 4-mo duration. Radiographic, ultrasonographic, and computed tomographic evaluation revealed an intrapelvic mass that was compressing the distal colon. Because of the difficulties of postsurgical management of this animal, the owner requested euthanasia. On postmortem examination, a mass measuring 3 times 5 times 10 cm was found arising from the body of the uterus. Histopathologic evaluation of the mass revealed a leiomyoma of the uterus. This case report documents the presence of a uterine tumor in a large felid that resulted in constipation and obstipation. Additionally, the value and limitations of the imaging modalities used to provide diagnostic, prognostic, and treatment options are discussed.


Subject(s)
Colonic Diseases/veterinary , Intestinal Obstruction/veterinary , Leiomyoma/veterinary , Panthera , Uterine Neoplasms/veterinary , Animals , Colon/pathology , Colonic Diseases/etiology , Colonic Diseases/surgery , Fatal Outcome , Female , Intestinal Obstruction/etiology , Intestinal Obstruction/surgery , Leiomyoma/complications , Uterine Neoplasms/complications
12.
J Wildl Dis ; 40(4): 769-74, 2004 Oct.
Article in English | MEDLINE | ID: mdl-15650098

ABSTRACT

A trumpeter swan (Cygnus buccinator) was observed near a mill pond in Picher, Oklahoma, USA. It became weakened and emaciated after about 1 mo, was captured with little resistance, and taken into captivity for medical care. Serum chemistry results were consistent with hepatic, renal, and muscular damage. Serum zinc concentration was elevated at 11.2 parts per million (ppm). The swan was treated for suspected heavy-metal poisoning, but died overnight. Gross postmortem findings were emaciation and pectoral muscle atrophy. Histopathologic lesions in the pancreas included mild diffuse disruption of acinar architecture, severe diffuse depletion or absence of zymogen granules, occasional apoptotic bodies in acinar epithelial cells, and mild interstitial and capsular fibrosis. Zinc concentration in pancreas was 3,200 ppm wet weight, and was similar to that reported in the pancreases of waterfowl known to be killed by zinc toxicity. Zinc concentrations in liver (154 ppm) and kidneys (145 ppm) also were elevated. Acute tubular necrosis of the collecting tubules of the kidneys was also possibly due to zinc toxicity. To the authors' knowledge, this is the first confirmed case of zinc poisoning in a trumpeter swan associated with mining wastes.


Subject(s)
Animals, Wild , Anseriformes , Bird Diseases/epidemiology , Water Pollutants, Chemical/poisoning , Zinc/poisoning , Animals , Bird Diseases/pathology , Fatal Outcome , Female , Kidney/chemistry , Kidney/metabolism , Kidney/pathology , Liver/chemistry , Liver/metabolism , Liver/pathology , Muscle, Skeletal/chemistry , Muscle, Skeletal/metabolism , Muscle, Skeletal/pathology , Oklahoma/epidemiology , Organ Specificity , Pancreas/chemistry , Pancreas/metabolism , Pancreas/pathology
13.
Vet Surg ; 31(6): 533-40, 2002.
Article in English | MEDLINE | ID: mdl-12415522

ABSTRACT

OBJECTIVE: To evaluate the Bone Injection Gun (BIG) for placement of intraosseous cannulas through impact penetration and compare it with a standard Jamshidi bone marrow needle (JBMN) and to compare fluid delivery dynamics through each device. STUDY DESIGN: Randomized in vivo study. ANIMALS: Forty-eight mature dogs. METHODS: During surgical laboratories, dogs were randomly assigned to 2 groups (n = 24), and intraosseous access in the proximal tibial metaphysis was obtained using a BIG or JBMN. Variables measured during placement included insertion success, time required for placement, and alterations in respiratory rate (RR), heart rate (HR), and systolic blood pressure. After placement, maintenance fluids were administered to 6 dogs from each group, and fluids were administered under pressure to 6 dogs from each group to compare rates of delivery through each device. After euthanasia, the tibiae were harvested to evaluate and compare the morphologic consequences of needle and cannula placement. RESULTS: Successful placement occurred in 20 (83%) dogs for the BIG and 23 (96%) dogs for the JBMN, which was not significantly different (P =.3475). Time required for placement was significantly less (P =.0024) for the BIG (mean, 22.4 +/- 8.2 seconds) compared with the JBMN (mean, 42.0 +/- 28.1 seconds). Significant increases in RR occurred in both groups and in the HR for the BIG group, but significant differences were not noted between groups. Mean rate of pressurized fluid administration was similar for both groups. Two distinct patterns of cortical bone damage occurred, but the clinical significance of this observation is uncertain. CONCLUSIONS: The BIG provides more rapid access to the intraosseous space for fluid administration than the JBMN. CLINICAL RELEVANCE: The BIG is an effective alternative for obtaining rapid access to the intraosseous space for emergency fluid and drug administration.


Subject(s)
Dogs/surgery , Infusions, Intraosseous/veterinary , Animals , Blood Pressure , Emergency Treatment/veterinary , Female , Heart Rate , Infusions, Intraosseous/instrumentation , Infusions, Intraosseous/methods , Infusions, Intraosseous/standards , Male , Respiration , Tibia , Time Factors
14.
J Am Vet Med Assoc ; 220(5): 633-9, 2002 Mar 01.
Article in English | MEDLINE | ID: mdl-12418523

ABSTRACT

OBJECTIVE: To determine signalment, history, clinical findings, results of autonomic function testing and other antemortem diagnostic tests, and pathologic findings in dogs with dysautonomia. DESIGN: Retrospective study. ANIMALS: 65 dogs with dysautonomia. PROCEDURE: Case records of 68 dogs with a diagnosis of dysautonomia were reviewed; inclusion criteria included histologic confirmation of dysautonomia or clinical signs and results of pharmacologic testing consistent with dysautonomia. RESULTS: 65 dogs fulfilled all criteria for dysautonomia. Dogs from rural environments were overrepresented, and cases of dysautonomia were reported for every month, although the highest number of cases was reported in February and March. Vomiting was the most common clinical sign, followed by diarrhea, signs of anorexia and depression, weight loss, and dysuria. The most common physical examination finding was decreased or absent anal tone, followed by absent pupillary light reflexes and elevated nictitating membrane. Results of pharmacologic testing were consistent with dysautonomia, although no single test was 100% sensitive. Histologic lesions consistent with dysautonomia were found in the autonomic ganglia, brainstem nuclei, and ventral horns of the spinal cord. CONCLUSIONS AND CLINICAL RELEVANCE: Dysautonomia is an endemic disease in Kansas, and a high index of suspicion of the disease can be made by combining clinical signs, physical examination findings, and results of pharmacologic testing.


Subject(s)
Autonomic Nervous System Diseases/veterinary , Dog Diseases/epidemiology , Age Factors , Animals , Anorexia/etiology , Anorexia/veterinary , Autonomic Nervous System Diseases/diagnosis , Autonomic Nervous System Diseases/epidemiology , Autonomic Nervous System Diseases/pathology , Diagnosis, Differential , Diarrhea/etiology , Diarrhea/veterinary , Dog Diseases/diagnosis , Dog Diseases/pathology , Dogs , Female , Kansas/epidemiology , Male , Pedigree , Retrospective Studies , Risk Factors , Rural Population , Seasons , Vomiting/etiology , Vomiting/veterinary
15.
Vet Surg ; 31(3): 259-65, 2002.
Article in English | MEDLINE | ID: mdl-11994854

ABSTRACT

OBJECTIVE: To describe an unusual case of fatal aortic aneurysm rupture after standard ligation of a left-to-right shunting patent ductus arteriosus (PDA) and review the literature concerning the causes of aneurysm and applicable medical physics of blood flow that may contribute to mural failure. STUDY DESIGN: Clinical case report. SAMPLE POPULATION: An 11-month-old female Brittany spaniel. RESULTS: A PDA was diagnosed in the dog after referral for a grade IV/IV cardiac murmur. Diagnostic tests performed included a minimum database, thoracic radiography, and echocardiography. Conventional surgical ligation of the PDA was performed. The postoperative recovery from anesthesia was uneventful. Approximately 5 hours after surgery, the dog vocalized once and collapsed. All resuscitative efforts failed. Necropsy showed a large, spiral rupture of the cranial and dorsal wall of the aorta that extended from the left subclavian artery to 2 cm distal to the PDA-aorta junction. No evidence of intramural, perianeurysmal hemorrhage or inflammation was noted. Histopathologic examination of the ruptured aneurysm showed that the wall lacked a defined tunica intima and endothelial cell layer. A distinct separation of the thinned tunica media parallel to the elastic fibers was noted. CONCLUSIONS AND CLINICAL RELEVANCE: Dilatation of the aorta near the area of a PDA is one of the recognized abnormalities associated with the condition. Aneurysmal dilatation results from and contributes to abnormal blood flow dynamics and increased aortic wall tension, which promotes expansion. Although an unusual and previously unreported sequela, rupture of the aneurysm should be considered a possible complication when ligation of a PDA with a conspicuous aortic aneurysmal dilation is performed.


Subject(s)
Aortic Rupture/veterinary , Dilatation/veterinary , Dog Diseases/surgery , Ductus Arteriosus, Patent/veterinary , Animals , Aortic Rupture/etiology , Dilatation/adverse effects , Dog Diseases/diagnostic imaging , Dogs , Ductus Arteriosus, Patent/surgery , Fatal Outcome , Female , Postoperative Complications/veterinary , Radiography , Ultrasonography
16.
J Vet Diagn Invest ; 14(2): 140-9, 2002 Mar.
Article in English | MEDLINE | ID: mdl-11939335

ABSTRACT

A degenerative skeletal muscle disease with vascular, neurologic, and renal lesions and a probable familial distribution was identified in 4-20-month-old purebred Gelbvieh cattle. Thirteen affected animals were confirmed from 6 separate beef herds, with a mortality rate of 100%. Clinical signs in affected animals consisted of ataxia, weakness, and terminal recumbency. Gross and histologic muscle lesions were indicative of nutritional myopathy of ruminants, with a lack of myocardial lesions in most cases and only rare myocardial changes in a few animals. Acute to chronic lesions in most large skeletal muscle groups consisted of degeneration, necrosis, regeneration, fibrosis, and atrophy. Fibrinoid necrosis of arterioles was a common feature in multiple tissues. Lesions in the spinal cord white matter and peripheral nerves consisted of degeneration of the dorsal columns and axons, respectively. Changes in the kidneys consisted of chronic interstitial nephritis with fibrosis, hyaline droplet change and tubular epithelial vacuolar change and were most severe in the older calves. Intracytoplasmic myoglobin and iron were demonstrated within the hyaline droplets in degenerate renal cortical tubular epithelial cells. Vitamin E levels were deficient in most (6/7) of the animals tested. Investigation of the pedigree of affected animals revealed a common ancestry for all but 1 of the animals whose parentage could be traced. This investigation suggests that a hereditary metabolic defect, possibly involving antioxidant metabolism, could be responsible for this condition. Renal disease, possibly secondary to myoglobinuria, may be unique to this bovine condition.


Subject(s)
Cattle Diseases/genetics , Neuromuscular Diseases/genetics , Neuromuscular Diseases/veterinary , Animals , Antioxidants/metabolism , Ataxia/etiology , Ataxia/veterinary , Cattle , Cattle Diseases/pathology , Fatal Outcome , Female , Kidney Diseases/etiology , Kidney Diseases/pathology , Kidney Diseases/veterinary , Male , Metabolic Diseases/genetics , Metabolic Diseases/veterinary , Muscle Weakness/veterinary , Pedigree , Vitamin E/metabolism
17.
J Vet Diagn Invest ; 14(2): 162-4, 2002 Mar.
Article in English | MEDLINE | ID: mdl-11939340

ABSTRACT

An immunohistochemical test was developed and validated for detection of Francisella tularensis antigen in tissues of cats with fatal tularemia. Ten cases of naturally occurring tularemia in cats were positive both by isolation of F. tularensis and immunohistochemical identification of F. tularensis antigen. Nine additional cases with lesions typical of tularemia were positive for F. tularensis antigen, although bacterial cultures were not performed. Immunohistochemical identification of F. tularensis in formalin-fixed tissue is valuable for establishing a rapid etiologic diagnosis under circumstances where fresh tissues may not be available for isolation and identification of the organism.


Subject(s)
Cat Diseases/diagnosis , Francisella tularensis/immunology , Immunohistochemistry/veterinary , Tularemia/veterinary , Animals , Antigens, Bacterial/analysis , Cat Diseases/immunology , Cats , Francisella tularensis/isolation & purification , Francisella tularensis/pathogenicity , Tularemia/diagnosis , Tularemia/immunology
18.
Vet Clin Pathol ; 27(1): 11-14, 1998.
Article in English | MEDLINE | ID: mdl-12075554

ABSTRACT

The assay of Makimura and Suzuki for serum haptoglobin has been adapted to use one tube with both semiautomated and robotic methods. The adaptation permits the determination of haptoglobin in several hundred serum samples per day. Both methods were strongly correlated with the original two-tube method and had within-assay variability of 4.4% for the semiautomated and 4.8% for the robotic method. Day-to-day variability averaged 6.0% for the semiautomated and 5.5% for the robotic method. The y-intercepts for both assays were higher than that of the original two-tube method, and thus, reference values are higher than those reported previously.

20.
Vet Clin Pathol ; 21(2): 57-60, 1992.
Article in English | MEDLINE | ID: mdl-12671803

ABSTRACT

An improved serum ferritin assay for canine serum has been developed. It uses two monoclonal antibodies in a sandwich arrangement. Serum ferritin can be determined on undiluted canine sera with this assay. The recovery of ferritin added to canine serum ranged from 98 to 106%, the within-assay coefficient of variability was 3.3 to 4.5%, and the assay-to-assay variability was 9.8 to 10.2%. Serum ferritin from 61 apparently healthy dogs had a geometric mean of 252 ng/ml, with a range of 80 ng/ml to 800 ng/ml.

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