Exploration of the polymorphic solid-state landscape of an amide-linked organic cage using computation and automation.

Organic cages can possess complex, functionalised cavities that make them promising candidates for synthetic enzyme mimics. Conformationally flexible, chemically robust structures are needed for adaptable guest binding and catalysis, but rapidly exchanging systems are difficult to resolve in solution. Here, we use low-cost calculations and high-throughput crystallisation to identify accessible conformers of a recently reported organic cage by 'locking' them in the solid state. The conformers exhibit varying distances between the internal carboxylic acid groups, suggesting adaptability for binding a wide array of target guest molecules.

Teleradiology: managing change through technology innovation.

This teleradiology initiative is one of many examples of innovative approaches being pursued and implemented throughout the U.S. Army Health Services Command. In recognition of wide-ranging innovative practices, which include the teleradiology project, the command was recognized in the 1989 Healthcare Forum/3M Organizational Innovator Awards program as the gold medal award winner in the government facilities category. The teleradiology project is representative of the command's commitment: constantly striving toward improvement in the delivery of health services.