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Klin Med (Mosk) ; 90(10): 24-7, 2012.
Article in Russian | MEDLINE | ID: mdl-23285757

ABSTRACT

We studied the development of metabolic disorders related to tissue hypoxia in 54 patients with acute severe asaleptin intoxication complicated by acute respiratory insfficiency of mixed genesis. We also estimated the role of a substrate antihypoxant cytoflavin in the correction of these disorders and clinical features of acute intoxication. Cyroflavin was shown to accelerate normalization of metabolic disorders which in turn improves clinical symptoms of severe forms of acute asaleptin intoxication.


Subject(s)
Antipsychotic Agents/poisoning , Clozapine/poisoning , Respiratory Insufficiency/physiopathology , Acute Disease , Adult , Drug Combinations , Female , Flavin Mononucleotide/pharmacology , Humans , Hypoxia/pathology , Inosine Diphosphate/pharmacology , Male , Metabolic Diseases/drug therapy , Metabolic Diseases/physiopathology , Middle Aged , Niacinamide/pharmacology , Severity of Illness Index , Succinates/pharmacology , Young Adult
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