ABSTRACT
OBJECTIVE: The aim of the study is to investigate the state of volumetric and osmoregulatory function of the kidneys in diabetes complicated by the syndrome of the endogenous intoxication of purulent-septic genesis. PATIENTS AND METHODS: Materials and methods: The study group was consisted of patients with insulin-dependent diabetes mellitus with complicated syndrome of the endogenous intoxication of purulent-septic genesis (CSDI). RESULTS: Results: The starting indices of volumetric and osmoregulatory function of the kidneys in patients with INCs complicated by the endogenous intoxication of purulent-septic genesis (CEI GHG) syndrome are characterized by the values of the inhibition of the volumorregulatory (by the clearance of sodium by 11%, p <0.05) and the activation of the osmoregulatory osmotically active substances by 23%, p <0.05) renal function. The volume increasing of the extracellular space by the Ringer solution activates the volumetric and osmoregulatory function of the kidneys, respectively, in patients with NSCL at 162 ± 27.1% (Δ, p <0.05) and 138 ± 48.3% (Δ, p <0.05), and at INCS complicated CEE GHS by 260 ± 47.8% (Δ, p <0.05) and 147 ± 46.9% (Δ, p <0.05). CONCLUSION: Conclusions: The low-level isotonic loads with Ringer's solution initiate the same direction of change in indices of volumetric and osmoregulatory function of the kidneys in patients with systemic inflammatory response syndrome and diabetes mellitus with complicated endogenous intoxication syndrome of purulent-septic genesis and show dissociative hyper reactivity of the volumorregulatory function in relation to the osmoregulatory one.
Subject(s)
Kidney , Diabetes Mellitus, Type 1 , HumansABSTRACT
OBJECTIVE: Introduction: One of the most important problems of our time is the HIV epidemic. Over a 30-year history of this disease, more than 75 million people were infected with HIV, nearly of which 30 million adults and children died [1, 2]. In the coming decades, they will continue to play a significant role in world premature mortality rates. The aimof the work is to determine the incidence of CKD, concomitant hepatitis B and C, and other most common opportunists in HIV infection, as well as to assess the diagnostic value of clinical and laboratory symptoms of renal impairment in immunocompromised patients. PATIENTS AND METHODS: Materials and methods: 292 HIV-infected patients were screened on an outpatient screening at the Chernivtsi Regional AIDS Center. To be based on the main markers of kidney damage, the persistent proteinuria (PU) and velocity of glomerular filtration (GFR) <60 ml / min / 1.73 m2 - in 16.4% of cases, chronic kidney disease (CKD) was diagnosed, which was accompanied by a high frequency with a violation functions of these organs. RESULTS: Results: A high frequency of opportunistic diseases of viral etiology was detected in persons with PU, which may be due to the involvement of the kidneys in the pathological process of cytomegalovirus infection and, accordingly, the more frequent use of potentially nephrotoxic antiviral drugs. Significantly more arterial hypertension (AG) is detected in the case of PU than in the absence of protein in the urine (<0.001). In addition, hemoglobin and GFR levels in patients with persistent PU were lower in comparison with patients without this symptom, indicating a relationship between proteinuria and anemia and renal dysfunction. CONCLUSION: Conclusions: There was a tendency to decrease the level of proteinuria with age (> 0.05), which may be due to the lesser development of glomerular kidney damage in the older age group. GFR in women is significantly lower than in men (> 0.05), which indicates a more significant renal dysfunction in women.
