[Study of plasma and hepatic hydrolysis of nitroxinil derivatives]. / Etude de l'hydrolyse plasmatique et hépatique de dérivés du Nitroxinil.

Seven esters derivatives of Nitroxinil were prepared and their structures were assigned by IR and 1H-NMR spectroscopy. The rate of plasma and hepatic hydrolysis were evaluated in vitro in sheep and rabbit. In view of this profile of activity, pivaloyl derivative merits evaluation, in vivo.

[The beta-adrenolytic activity of new arylmethyloxypropanolamine analogs of dioxadilol]. / Etude de l'activité beta adrénolytique de nouvelles arylméthyloxypropanolamines analogues du Dioxadilol.

A series of arylmethyloxypropanolamines structurally related to Dioxadilol has been synthesized and tested for their beta adrenolytic activity. Only one compound, the benzofuranic derivative 3c, exhibited a similar activity as Dioxadilol but was less potent than propranolol.