ABSTRACT
The organocatalytic asymmetric Morita-Baylis-Hillman (MBH) reaction produces a significant carbon-carbon bond formation that involves the addition of α,ß-unsaturated carbonyl compounds to activated alkenes to give α-methylene-ß-hydroxycarbonyl compounds. Commercially available starting materials, excellent atom economy, mild reaction conditions, and flexible products are the major highlights of this method. In this review, we discuss the recent developments in the organocatalytic MBH reaction, covering literature from 2018 to 2023.
ABSTRACT
Transition metal catalyzed Sonogashira coupling reaction has evolved as an efficient pathway for the construction of C-C bonds. Initially, palladium cooperating with copper was considered as the efficient catalytic system for this reaction. However, nowadays there have been astonishing progress in copper catalyzed Sonogashira coupling reactions. Copper catalyzed reactions have attained significant attention owing to the cost effective and environmentally benign characteristics of this metal compared to palladium. This review summarizes the recent developments in copper catalyzed Sonogashira coupling covering literature from 2014 to 2021.
ABSTRACT
The cyanation reaction has achieved rapid progress in recent times. The ability to exhibit multiple oxidation states increased the demand of ruthenium in the field of catalysis. These cyanation reactions have wide application in pharmacological and biological fields. This review gives an overview of the ruthenium-catalyzed cyanation reactions covering literature up to 2021.
ABSTRACT
Spirooxindole is a principal bioactive agent and is observed in several natural products including alkaloids. They are broadly studied in the pharmaceutical field and have a significant role in the evolution of drugs such as anti-viral, anti-cancer, anti-microbial etc. In organic chemistry, an indispensable role is presented by transition metal catalysts. An effective synthetic perspective to spirooxindoles is the use of transition metals as the catalyst. This review discusses the synthesis of spirooxindoles catalyzed by transition metals and covers literature up to 2020.
ABSTRACT
Propargylamines are a class of compounds with many pharmaceutical and biological properties. A green approach to synthesize such compounds is very relevant. This review aims to describe the solvent-free synthetic approaches towards propargylamines via A3 and KA2 coupling reactions covering the literature up to 2021.
ABSTRACT
Pyrazole and its derivatives have gained wide attention in pharmaceutical, agrochemical and biological fields as well as in industry. They exhibit various biological activities such as anti-pyretic, anti-microbial, anti- inflammatory, anti-tumor, anti-viral, anti-histaminic, anti-convulsant, fungicidal, insecticidal, etc. In this review, we summarise the recent advances in the synthesis of pyrazole derivatives using various methodologies and covers literature from 2017-2020.
ABSTRACT
Copper-catalyzed C-H functionalization is becoming a significant area in organic chemistry. Copper is now widely used as a catalyst in organic synthesis as it is inexpensive and not very toxic. Functionalization of C-H bonds to construct wide varieties of organic compounds has received much attention in recent times. This review focuses on the recent advances in Cu-catalyzed C-H functionalization and covers literature from 2018-2020.
ABSTRACT
Aryl nitriles are compounds with wide significance. They have made their own space in various sectors including pharmaceuticals, industries, natural product chemistry, and so on. Furthermore, they are also key intermediates in various transformations in organic chemistry. Transition metal-catalyzed cyanation reactions have proved to be a better replacement for the existing traditional synthetic strategies for aryl nitriles. Palladium is one of the most studied transition metals other than copper and nickel owing to its wide functional group compatibility and catalytic efficacy. There have been drastic developments in the field of palladium-catalyzed cyanation since its discovery in the 1973. This review summarizes the recent developments in the palladium-catalyzed cyanation of aryl halides and covers literature from 2012-2020.
