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1.
Sci Rep ; 10(1): 9631, 2020 Jun 15.
Article in English | MEDLINE | ID: mdl-32541818

ABSTRACT

High temperature studies of spin Hall effect have often been neglected despite its profound significance in real-world devices. In this work, high temperature spin torque ferromagnetic resonance measurement was performed to evaluate the effects of temperature on the Gilbert damping and spin Hall efficiency of PtxCu1-x. When the temperature was varied from 300 K to 407 K, the Gilbert damping was relatively stable with a change of 4% at composition x = 66%. Alloying Pt and Cu improved the spin Hall efficiency of Pt75Cu25/Co/Ta by 29% to a value of 0.31 ± 0.03 at 407 K. However, the critical switching current density is dependent on the ratio between the Gilbert damping and spin Hall efficiency and the smallest value was observed when x = 47%. It was found that at this concentration, the spin transparency was at its highest at 0.85 ± 0.09 hence indicating the importance of interfacial transparency for energy efficient devices at elevated temperature.

2.
Br J Dermatol ; 182(2): 410-417, 2020 02.
Article in English | MEDLINE | ID: mdl-31049930

ABSTRACT

BACKGROUND: The European League Against Rheumatism/American College of Rheumatology classification criteria for inflammatory myopathies are able to classify patients with skin-predominant dermatomyositis (DM). However, approximately 25% of patients with skin-predominant DM do not meet two of the three hallmark skin signs and fail to meet the criteria. OBJECTIVES: To develop a set of skin-focused classification criteria that will distinguish cutaneous DM from mimickers and allow a more inclusive definition of skin-predominant disease. METHODS: An extensive literature review was done to generate items for the Delphi process. Items were grouped into categories of distribution, morphology, symptoms, antibodies, histology and contextual factors. Using REDCap™, participants rated these items in terms of appropriateness and distinguishing ability from mimickers. The relevance score ranged from 1 to 100, and the median score determined a rank-ordered list. A prespecified median score cut-off was decided by the steering committee and the participants. There was a pre-Delphi and two rounds of actual Delphi. RESULTS: There were 50 participating dermatologists and rheumatologists from North America, South America, Europe and Asia. After a cut-off score of 70 during the first round, 37 of the initial 54 items were retained and carried over to the next round. The cut-off was raised to 80 during round two and a list of 25 items was generated. CONCLUSIONS: This project is a key step in the development of prospectively validated classification criteria that will create a more inclusive population of patients with DM for clinical research. What's already known about this topic? Proper classification of patients with skin-predominant dermatomyositis (DM) is indispensable in the appropriate conduct of clinical/translational research in the field. The only validated European League Against Rheumatism/American College of Rheumatology criteria for idiopathic inflammatory myopathies are able to classify skin-predominant DM. However, a quarter of amyopathic patients still fail the criteria and does not meet the disease classification. What does this study add? A list of 25 potential criteria divided into categories of distribution, morphology, symptomatology, pathology and contextual factors has been generated after several rounds of consensus exercise among experts in the field of DM. This Delphi project is a prerequisite to the development of a validated classification criteria set for skin-predominant DM.


Subject(s)
Dermatomyositis , Rheumatology , Asia , Delphi Technique , Dermatomyositis/diagnosis , Europe , Humans , North America
3.
Sci Rep ; 9(1): 17534, 2019 Nov 21.
Article in English | MEDLINE | ID: mdl-31754270

ABSTRACT

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

4.
Sci Rep ; 9(1): 7369, 2019 May 14.
Article in English | MEDLINE | ID: mdl-31089209

ABSTRACT

The use of voltage-controlled magnetic anisotropy (VCMA) via the creation of a sloped electric field has been hailed as an energy-efficient approach for domain wall (DW) propagation. However, this method suffers from a limitation of the nanowire length which the DW can propagate on. Here, we propose the use of multiplexed gate electrodes to propagate DWs on magnetic nanowires without having any length constraints. The multi-gate electrode configuration is demonstrated using micromagnetic simulations. This allows controllable voltages to be applied to neighboring gate electrodes, generating large strength of magnetic anisotropy gradients along the nanowire, and the results show that DW velocities higher than 300 m/s can be achieved. Analysis of the DW dynamics during propagation reveals that the tilt of the DW and the direction of slanted gate electrode greatly alters the steady state DW propagation. Our results show that chevron-shaped gate electrodes is an effective optimisation that leads to multi-DW propagation with high velocity. Moreover, a repeating series of high-medium-low magnetic anisotropy regions enables a deterministic VCMA-controlled high velocity DW propagation.

6.
Dermatol Online J ; 22(4)2016 Apr 18.
Article in English | MEDLINE | ID: mdl-27617467

ABSTRACT

A 19-year-old man with a 6-month history of progressive development of hyperpigmented, velvety plaques on the face and body. A diagnosis of idiopathic eruptive macular pigmentation with papillomatosis (IEMPP) was determined. This entity is discussed.


Subject(s)
Hyperpigmentation/pathology , Papilloma/pathology , Humans , Hyperpigmentation/diagnosis , Male , Papilloma/diagnosis , Young Adult
7.
Singapore Med J ; 53(1): e12-4, 2012 Jan.
Article in English | MEDLINE | ID: mdl-22252191

ABSTRACT

Acrokeratosis paraneoplastica of Bazex is a rare but important paraneoplastic dermatosis, usually manifesting as psoriasiform rashes over the acral sites. It often precedes diagnosis of the associated malignancy, usually that of upper aerodigestive tract squamous cell carcinoma. We present the case of a patient with a newly diagnosed pyriform sinus tumour and associated acrokeratosis paraneoplastica. To the best of our knowledge, this is the first reported case in the local literature.


Subject(s)
Carcinoma, Basal Cell/pathology , Dermatitis/diagnosis , Histiocytoma, Benign Fibrous/pathology , Hypotrichosis/pathology , Paraneoplastic Syndromes/pathology , Psoriasis/diagnosis , Pyriform Sinus/pathology , Skin Neoplasms/pathology , Carcinoma, Basal Cell/diagnosis , Carcinoma, Squamous Cell/diagnosis , Dermatitis/therapy , Dermatology/methods , Diagnosis, Differential , Histiocytoma, Benign Fibrous/diagnosis , Humans , Hypotrichosis/diagnosis , Lymphatic Metastasis/diagnosis , Male , Middle Aged , Paraneoplastic Syndromes/diagnosis , Psoriasis/therapy , Skin Neoplasms/diagnosis , Tomography, X-Ray Computed/methods
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