ABSTRACT
The acute haemodynamic effects of intravenous nisoldipine and hydralazine were compared in nine patients with heart failure. Both agents caused qualitatively similar effects, reducing both left ventricular preload and afterload, with reductions in systemic vascular resistance and increases in cardiac output. However, the effect of hydralazine was significantly greater and of longer duration than nisoldipine, and was associated with side effects in four patients. This, and previously reported data, suggests that nisoldipine may be useful in patients with ischaemia and concomitant heart failure.
Subject(s)
Calcium Channel Blockers/pharmacology , Heart Failure/physiopathology , Hemodynamics/drug effects , Hydralazine/pharmacology , Nisoldipine/pharmacology , Adult , Aged , Angina Pectoris/physiopathology , Blood Pressure/drug effects , Calcium Channel Blockers/administration & dosage , Calcium Channel Blockers/therapeutic use , Cardiac Output/drug effects , Heart Failure/drug therapy , Humans , Hydralazine/administration & dosage , Hydralazine/therapeutic use , Injections, Intravenous , Male , Middle Aged , Nisoldipine/administration & dosage , Nisoldipine/therapeutic useABSTRACT
A sample of 20 men (10 right-handed, 10 left-handed) was selected. Using the method of constant stimuli, the number of correct responses and the differential threshold for weight and roughness for both hands, were studied. The findings were: (1) In the weight test, the number of correct responses was greater and the differential threshold lower in the right-handed than in the left-handed subjects, and the preferred hand was superior to the nonpreferred hand for both groups; (2) In the roughness test, the number of correct responses was greater and the differential threshold lower for the nonpreferred hand. Implications of these findings with regard to our present knowledge of handedness organization are analyzed.
Subject(s)
Functional Laterality/physiology , Touch/physiology , Weight Perception/physiology , Adult , Differential Threshold , Humans , Male , PsychophysicsABSTRACT
Two patients admitted to the medical intensive care unit with subarachnoid haemorrhage, one with the provisional diagnosis of 'sick sinus syndrome' the other as having an acute myocardial infarction complicated by ventricular tachycardia, are described and the arrhythmias associated with this condition are reviewed.
