ABSTRACT
BACKGROUND: The Noveon is a unique dual-wavelength near-infrared diode laser used to treat onychomycosis. The device operates at physiologic temperatures that are thermally safe for human tissue. It uses only 870- and 930-nm near-infrared light, wavelengths that have unique photolethal effects on fungal pathogens. These wavelengths lack the teratogenic danger presented by ultraviolet light and the photoablation toxic plume associated with pulsed Nd:YAG lasers. METHODS: In this randomized controlled study, treatments followed a predefined protocol and laser parameters and occurred on days 1, 14, 42, and 120. Toes were cultured and evaluated, and measurements were taken from standardized photographs obtained periodically during the 180 day follow-up period. RESULTS: We treated mycologically confirmed onychomycosis in 26 eligible toes (ten mild, seven moderate, and nine severe). All of the patients were followed-up for 180 days. An independent expert panel, blinded regarding treatment versus control, found that at 180 days, 85% of the eligible treated toenails were improved by clear nail linear extent (P = .0015); 65% showed at least 3 mm and 26% showed at least 4 mm of clear nail growth. Of the 16 toes with moderate to severe involvement, ten (63%) improved, as shown by clear nail growth of at least 3 mm (P = .0112). Simultaneous negative culture and periodic acid-Schiff was noted in 30% at 180 days. CONCLUSIONS: These results indicate a role for this laser in the treatment of onychomycosis, regardless of degree of severity. Ease of delivery and the lack of a need to monitor blood chemistry are attractive attributes.
Subject(s)
Foot Dermatoses/radiotherapy , Lasers, Semiconductor/therapeutic use , Low-Level Light Therapy/methods , Onychomycosis/radiotherapy , Adolescent , Adult , Aged , Female , Follow-Up Studies , Foot Dermatoses/diagnosis , Humans , Male , Middle Aged , Onychomycosis/diagnosis , Severity of Illness Index , Treatment Outcome , Young AdultABSTRACT
La obesidad mórbida representa un problema mundial cuya prevalencia se encuentra en aumento, sólo el enfoque quirúrgico ha demostrado resultados persistentes en cuanto a la pérdida de peso de manera permanente. Objetivo: evaluación del impacto social de la pérdida de peso en el paciente obeso posterior al tratamiento quirúrgico por medio de un bypass laparoscópico o convencional y análisis de costos operativos.(AU)
Morbid obesity represents a health-related problem rising all over the world, just the surgical management has demonstrted persistent and constant outcome in weight lose. Objective: Evaluations of the social impact and operative cost in weight lose obese morbid patients after laparoscopic or open gastric bypass.(AU)
Subject(s)
Humans , Obesity, Morbid/surgery , Anastomosis, Roux-en-Y , Bariatric Surgery , Body Mass Index , Quality of Life , Outcome Assessment, Health Care/statistics & numerical dataABSTRACT
La obesidad mórbida representa un problema mundial cuya prevalencia se encuentra en aumento, sólo el enfoque quirúrgico ha demostrado resultados persistentes en cuanto a la pérdida de peso de manera permanente. Objetivo: evaluación del impacto social de la pérdida de peso en el paciente obeso posterior al tratamiento quirúrgico por medio de un bypass laparoscópico o convencional y análisis de costos operativos.
Morbid obesity represents a health-related problem rising all over the world, just the surgical management has demonstrted persistent and constant outcome in weight lose. Objective: Evaluations of the social impact and operative cost in weight lose obese morbid patients after laparoscopic or open gastric bypass.
