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IGF2/ApaI polymorphism associated with birth weight in children of the region of Petrolina-PE, Brazil.

de Mascena Diniz Maia, Paula F C; da Silva, Tamiris M E; Angelo, Hildson D; e Silva, Laís W; Gondim Martins, Danyelly B; de Mascena Diniz Maia, Maria; de Lima Filho, José L.

J Matern Fetal Neonatal Med ; 26(3): 316-7, 2013 Feb.

Article in English | MEDLINE | ID: mdl-23039012

ABSTRACT

Insulin-like growth factor 2 (IGF2) gene has an important role in fetal growth. It was investigated association of the IGF2/ApaI polymorphism with low birth weight and normal birth weight (as control) in children attended in Hospital Dom Malan Petrolina, PE-Brazil. The genotype frequencies did not differ statistically between low birth weight (AA = 16.22%, AG = 43.24%, GG = 40.54%) and control (AA = 20% AG = 35%, GG= 45% groups) and the allele frequencies were not significantly different (p > 0.05).The observed genotype frequencies in both groups did not deviate significantly from Hardy-Weinberg equilibrium. Then, no significant correlation was found for this polymorphism in the population studied.

Subject(s)

Birth Weight/genetics , Insulin-Like Growth Factor II/genetics , Polymorphism, Restriction Fragment Length/physiology , Brazil , Case-Control Studies , Child , Deoxyribonucleases, Type II Site-Specific/metabolism , Female , Gene Frequency , Genetic Association Studies , Geography , Humans , Infant, Newborn , Insulin-Like Growth Factor II/metabolism , Polymorphism, Restriction Fragment Length/genetics , Pregnancy

ABSTRACT

Subject(s)

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