Hypersensitivity reactions to multiple biologicals in a pediatric patient with severe persistent asthma.

Asthma is a common chronic pediatric disease that negatively impacts the quality of patients' lives. While most cases can be effectively managed with a regimen of inhaled corticosteroids, severe cases require prolonged or frequent courses of oral corticosteroids or the addition of biologic therapies and allergen immunotherapy. Biologics are well tolerated with few side effects; however, reactions as severe as anaphylaxis have been reported. We present a pediatric patient with severe persistent asthma who developed hypersensitivity reactions to three different biologic agents.