ABSTRACT
BACKGROUND: Cisplatin is a well-known nephrotoxic antineoplastic drug. Chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria is one of the rare complications associated with its use. CASE PRESENTATION: A 42-year-old woman presented with a 20 year-history of hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria after cisplatin-based chemotherapy for ovarian cancer. This patient has had chronic muscle aches and fatigue and has had episodic seizure-like activity and periodic paralysis. Only thirteen other patients with similar electrolyte abnormalities have been described in the literature. This case has the longest follow-up. CONCLUSION: Cisplatin can cause permanent nephrotoxicity, including Gitelman-like syndrome. This drug should be considered among the possible causes of chronic unexplained electrolyte disorders.
Subject(s)
Alkalosis/chemically induced , Antineoplastic Agents/adverse effects , Calcium/urine , Cisplatin/adverse effects , Hypokalemia/chemically induced , Magnesium Deficiency/chemically induced , Ovarian Neoplasms/drug therapy , Adult , Antineoplastic Agents/therapeutic use , Arthralgia/chemically induced , Chronic Disease , Cisplatin/therapeutic use , Fatigue/chemically induced , Female , Humans , Magnesium Deficiency/blood , Paralysis/chemically induced , SyndromeABSTRACT
A case of primary lymphoepithelioma of the esophagus is presented in an Arabic female patient. This very rare Epstein-Barr virus infection-related malignancy has previously been reported only in patients from Japan. The tumor exhibited classic histologic and immunohistochemical features of lymphoepithelioma, and was successfully treated with neoadjuvant chemotherapy and irradiation followed by surgical resection.
