To sleep or not to sleep? No effect of sleep on contextual word learning in younger adults.

This study investigated the effect of sleep on novel word learning through reading context. Seventy-four healthy young adults attended two testing sessions, with either overnight sleep (sleep group) or daytime wakefulness (wake group) occurring between the sessions. At the initial learning session, participants identified the hidden meanings of novel words embedded within sentence contexts and were subsequently tested on their recognition of the novel word meanings. A recognition test was also conducted at the delayed session. The analyses revealed comparable recognition of novel word meanings for the sleep and wake group at both the initial and the delayed session, indicating that there was no benefit of sleep compared with wakefulness for novel word learning through context. Overall, this study highlights the critical influence of encoding method on sleep-dependent learning, where not all forms of word learning appear to benefit from sleep for consolidation.

Modulations of right hemisphere connectivity in young children relates to the perception of spoken words.

The early school years shape a young brain's capability to comprehend and contextualize words within milliseconds of exposure. Parsing word sounds (phonological interpretation) and word recognition (enabling semantic interpretation) are integral to this process. Yet little is known about the causal mechanisms of cortical activity during these early developmental stages. In this study, we aimed to explore these causal mechanisms via dynamic causal modelling of event-related potentials (ERPs) acquired from 30 typically developing children (ages 6-8 years) as they completed a spoken word-picture matching task. Source reconstruction of high-density electroencephalography (128 channels) was used to ascertain differences in whole-brain cortical activity during semantically "congruent" and "incongruent" conditions. Source activations analyzed during the N400 ERP window identified significant regions-of-interest (pFWE<.05) localized primarily in the right hemisphere when contrasting congruent and incongruent word-picture stimuli. Dynamic causal models (DCMs) were tested on source activations in the fusiform gyrus (rFusi), inferior parietal lobule (rIPL), inferior temporal gyrus (rITG) and superior frontal gyrus (rSFG). DCM results indicated that a fully connected bidirectional model with self-(inhibiting) connections over rFusi, rIPL and rSFG provided the highest model evidence, based on exceedance probabilities derived from Bayesian statistical inferences. Connectivity parameters of rITG and rSFG regions from the winning DCM were negatively correlated with behavioural measures of receptive vocabulary and phonological memory (pFDR<.05), such that lower scores on these assessments corresponded with increased connectivity between temporal pole and anterior frontal regions. The findings suggest that children with lower language processing skills required increased recruitment of right hemisphere frontal/temporal areas during task performance.

How Effective are Pictures in Eliciting Information from People Living with Dementia? A Systematic Review.

OBJECTIVES: Decline in language and cognitive functioning often deprives people living with moderate-to-severe dementia of self-reporting their quality of life (QoL) on the written and verbal formats of questionnaires. This systematic review aimed to evaluate the effectiveness of pictorial tools as an alternative method for enabling people living with dementia to self-report their QoL. METHODS: PubMed, PsycINFO, CINAHL, and EMBASE were searched. Primary research studies reporting on information elicitation from people living with dementia through pictures were deemed eligible. Six studies satisfied the inclusion criteria. Methodological quality of the studies was evaluated through Downs and Black checklist. Data was extracted according to population, intervention, comparator, and outcomes (PICO) and results were summarized and supplemented by narrative synthesis. RESULTS: Compared to usual communication methods, pictorial tools were found to have a superior effect on comprehension of conversations and decision-making abilities, minimal effect on preference consistency, and an undeterminable effect on discourse features. CONCLUSIONS: There is consistent evidence that pictures enhance comprehension and might facilitate decision-making abilities. CLINICAL IMPLICATIONS: QoL information can be elicited more effectively through pictorial tools. Future studies warrant development of pictorial versions of standardized QoL tools which will assist the inclusion of people living with severe dementia.

Putting "the broken bits together": A qualitative exploration of the impact of communication changes in dementia.

INTRODUCTION: Communication is an area of health and functioning that is profoundly affected by dementia. While it is known that people living with dementia and their care partners experience disruptions to daily activities and social engagement, detailed knowledge about the lived impact of dementia-related communication changes is lacking. This study sought an in-depth understanding of the lived experience of dementia-related communication changes and the associated impact, needs, and strategies. METHODS: As part of an overarching participatory design study, a qualitative (interpretive description) exploration was undertaken with people living with dementia and their care partners. Data from semi-structured interviews were analysed using thematic analysis. RESULTS: We interviewed 13 people living with dementia and 21 care partners and drew three themes and 10 subthemes from the interviews. The first theme illustrates how dementia changes communication which in turn changes life; the second captures the impact of changes on people living with dementia and care partners emotionally and in the context of relationships; and the third describes some positive and constructive ways of moving forward with dementia-related communication changes. CONCLUSIONS: Interventions to enhance function, participation, and wellbeing for people living with dementia and their care partners need to encompass support for communication changes. There is a need to ensure that people living with dementia feel dignified and respected during communication, and that care partners and inclusive communities are educated, trained, and supported to facilitate communication.

The effect of sleep and semantic information on associative novel word learning.

This study investigated the effect of overnight sleep on associative novel word learning and examined whether the effects of sleep on word learning are modulated by the provision of semantic information. Seventy-five healthy young adults attended an initial word-learning session followed by a delayed testing session. An interval of overnight sleep (sleep group) or daytime wakefulness (wake group) separated the two sessions. At the initial learning session, participants learned three-word names of 20 novel objects, where half the names comprised a novel word and two semantic attributes (semantic condition), and half comprised a novel word and two meaningless proper names (name condition). Novel word cued-recall was measured at both the initial and the delayed session. Although both groups demonstrated similar cued-recall accuracy at the first session, by the delayed session the sleep group demonstrated superior cued-recall accuracy compared to the wake group. There was no influence of semantics on the sleep-dependent consolidation of the novel words. Overall, these findings suggest that novel words encoded with or without the provision of semantic information can benefit from an overnight sleep period for consolidation.

Semantic fluency deficits and associated brain activity in Parkinson's disease with mild cognitive impairment.

People living with Parkinson's disease (PD) with poor verbal fluency have an increased risk of developing dementia. This study examines the neural mechanisms underpinning semantic fluency deficits in patients with PD with mild cognitive impairment (PD-MCI) compared to those without MCI (PD-NC) and control participants without PD (non-PD). Thirty-seven (37) participants with PD completed a cognitive assessment battery to identify MCI (13 PD-MCI). Twenty sex- and age-matched non-PD patients also participated. Participants were scanned (3T Siemens PRISMA) while performing semantic fluency, semantic switching, and automatic speech tasks. The number of responses and fMRI data for semantic generation and semantic switching were analyzed. Participants also completed a series of verbal fluency tests outside the scanner, including letter fluency. Participants with PD-MCI performed significantly worse than PD-NC and non-PD participants during semantic fluency and semantic switching tasks. PD-MCI patients showed greater activity in the right angular gyrus than PD-NC and non-PD patients during semantic switching. Increased right angular activity correlated with worse verbal fluency performance outside the scanner. Our study showed that the PD-MCI group performed worse on semantic fluency than either the PD-NC or non-PD groups. Increased right angular gyrus activity in participants with PD-MCI during semantic switching suggests early compensatory mechanisms, predicting the risk of future dementia in PD.

Acquisition of novel word meaning via cross situational word learning: An event-related potential study.

Cross-situational statistical word learning (CSWL) refers to the process whereby participants learn new words by tracking ambiguous word-object co-occurrences across time. This study used event-related potentials to explore the acquisition of novel word meanings via CSWL in healthy adults. After learning to associate novel auditory words (e.g., 'ket') with familiar objects (e.g., sword), participants performed a semantic judgement task where the learned novel words were paired with a familiar word belonging to either the same (e.g., dagger) or a different (e.g., harp) semantic category. As a comparison, the task also included word pairs comprising two familiar words. The analyses revealed that the unrelated novel word pairs elicited a similar N400 to that of the unrelated familiar word pairs, but with a different hemispheric distribution (left hemisphere for novel words, right hemisphere for familiar words). These findings demonstrate rapid meaning acquisition via CSWL, which is reflected at a neurophysiological level.

Effects of emotional cues on novel word learning in typically developing children in relation to broader autism traits.

Emotion can influence various cognitive processes. Communication with children often involves exaggerated emotional expressions and emotive language. Children with autism spectrum disorder often show a reduced tendency to attend to emotional information. Typically developing children aged 7 to 9 years who varied in their level of autism-like traits learned the nonsense word names of nine novel toys, which were presented with either happy, fearful, or neutral emotional cues. Emotional cues had no influence on word recognition or recall performance. Eye-tracking data showed differences in visual attention depending on the type of emotional cues and level of autism-like traits. The findings suggest that the influence of emotion on attention during word learning differs according to whether the children have lower or higher levels of autism-like traits, but this influence does not affect word learning outcomes.

Dorsal and Ventral Cortical Connectivity Is Mediated by the Inferior Frontal Gyrus During Facilitated Naming of Pictures.

Background: It is well recognized that semantic processing and auditory repetition facilitate subsequent naming of pictures. However, the neurocognitive mechanisms that underpin these facilitation effects remain unclear. Materials and Methods: The current study utilized a dynamic causal modeling (DCM) approach to examine high-density electroencephalographic (128-channel EEG) recordings and investigate connectivity modulations during facilitated naming of pictures in 18 healthy older adults (mean age 61.50 years). Source reconstruction of event-related potentials was performed in two specific time windows, (1) 150-250 msec and (2) 300-500 msec, to establish the timescale of significant cortical activations present during participation of semantic and phonological tasks. Hypothesis-driven DCM of source-activated regions was tested to ascertain which model most likely explained the semantic and phonological conditions, respectively. Results: DCM results indicated that a common cortical network comprising dorsal and ventral cortical connections best explained EEG task data derived from repetition and semantic tasks. For repetition (phonological) tasks, this model featured long feedback, bidirectional connections from inferior frontal gyrus (IFG) to occipitotemporal areas. Semantic tasks were most plausibly explained by a model that featured a self-inhibiting connection over the IFG only. Conclusions: Findings from this study reveal that a common cortical model comprising pathways that include dorsal and ventral regions is appropriate for characterizing EEG naming facilitation data, and that distinct cortical connections explain differences between semantic and auditory repetition processes. These models could be repurposed for naming facilitation paradigms in patients with language difficulties to optimize prediction and responsiveness to such paradigms. Impact statement The combination of semantic (word-level) and phonological (sound-level) processing in the cortex facilitates one of the most robust responses-the naming of pictures. Here, dynamic causal modeling of high-density electroencephalography during facilitated naming tasks revealed a model consisting of common dorsal and ventral connections that best explained response to semantic and phonological stimuli. Within this cortical network, phonological facilitation involved a long-range connection from inferior frontal gyrus (IFG) to occipitotemporal regions, whereas semantic facilitation contributed to self-inhibition of the IFG. The IFG is therefore a key region mediating cortical activity when switching between phonological and semantic conditions.

The effect of sleep on novel word learning in healthy adults: A systematic review and meta-analysis.

There is increasing evidence to indicate that sleep plays a role in language acquisition and consolidation; however, there has been substantial variability in methodological approaches used to examine this phenomenon. This systematic review and meta-analysis aimed to investigate the effect of sleep on novel word learning in adults, and explore whether these effects differed by retrieval domain (i.e., recall, recognition, and tests of lexical integration). Twenty-five unique studies met the inclusion criteria for the review, and 42 separate outcome measures were synthesized in the meta-analysis (k = 29 separate between-group comparisons, n = 1,396 participants). The results from the omnibus meta-analysis indicated that sleep was beneficial for novel word learning compared with wakefulness (g = 0.50). Effect sizes differed across the separate domain-specific meta-analyses, with moderate effects for recall (g = 0.57) and recognition memory (g = 0.52), and a small effect for tasks which measured lexical integration (g = 0.39). Overall, the results of this meta-analysis indicate that sleep generally benefits novel word acquisition and consolidation compared with wakefulness across differing retrieval domains. This systematic review highlights the potential for sleep to be used to improve second-language learning in healthy adults, and overall provides further insight into methods to facilitate language development.

Corticostriatal Regulation of Language Functions.

The role of corticostriatal circuits in language functions is unclear. In this review, we consider evidence from language learning, syntax, and controlled language production and comprehension tasks that implicate various corticostriatal circuits. Converging evidence from neuroimaging in healthy individuals, studies in populations with subcortical dysfunction, pharmacological studies, and brain stimulation suggests a domain-general regulatory role of corticostriatal systems in language operations. The role of corticostriatal systems in language operations identified in this review is likely to reflect a broader function of the striatum in responding to uncertainty and conflict which demands selection, sequencing, and cognitive control. We argue that this role is dynamic and varies depending on the degree and form of cognitive control required, which in turn will recruit particular corticostriatal circuits and components organised in a cognitive hierarchy.

The influence of contextual constraint on verbal selection mechanisms and its neural correlates in Parkinson's disease.

A small number of studies have described verbal selection deficits in Parkinson's disease (PD) when selection must occur among competing alternatives. However, these studies have largely focused on single-word processing, or have utilised sentence stems that carry high contextual constraint, thus reducing selection demands. The present study aimed to determine the influence of variable contextual constraint on the selection of a verbal response in PD. This was achieved using an adaption of the Hayling Sentence Completion Task whereby PD participants and matched controls were required to provide a single word to complete a cloze probability sentence stem that carried a low, medium, or high degree of contextual constraint. Results revealed no main effect of group in terms of response time or accuracy, though a group-by-condition interaction in accuracy was noted. This was characterised by a significant difference in accuracy between low and medium levels of constraint for control participants, but no significant difference for the PD group. Functional MRI data revealed marked between-group differences in underlying neural activity. The control group showed increased recruitment of the dorsal striatum and the vlPFC under conditions that placed greater demands upon selection (i.e. low and medium constraint), and greater activity overall in the left dlPFC and right vlPFC. However, in the PD group, behavioural performance appeared to be maintained despite underlying decreases in frontostriatal activity, suggesting other compensatory mechanisms that may include changes in functional connectivity or an over-medication effect in frontal networks in response to loss of signalling in cortico-subcortical pathways.

Theta and gamma connectivity is linked with affective and cognitive symptoms in Parkinson's disease.

BACKGROUND: The progression of Parkinson's disease (PD) can often exacerbate symptoms of depression, anxiety, and/or cognitive impairment. In this study, we explore the possibility that multiple brain network responses are associated with symptoms of depression, anxiety and cognitive impairment in PD. This association is likely to provide insights into a single multivariate relationship, where common affective symptoms occurring in PD cohorts are related with alterations to electrophysiological response. METHODS: 70 PD patients and 21 healthy age-matched controls (HC) participated in a high-density electroencephalography (EEG) study. Functional connectivity differences between PD and HC groups of oscillatory activity at rest and during completion of an emotion-cognition task were examined to identify key brain oscillatory activities. A canonical correlation analysis (CCA) was applied to identify a putative multivariate relationship between connectivity patterns and affective symptoms in PD groups. RESULTS: A CCA analysis identified a single mode of co-variation linking theta and gamma connectivity with affective symptoms in PD groups. Increases in frontotemporal gamma, frontal and parietal theta connectivity were related with increased anxiety and cognitive impairment. Decreases in temporal region theta and frontoparietal gamma connectivity were associated with higher depression ratings and PD patient age. LIMITATIONS: This study only reports on optimal dosage of dopaminergic treatment ('on' state) in PD and did not investigate at "off" medication". CONCLUSIONS: Theta and gamma connectivity during rest and task-states are linked to affective and cognitive symptoms within fronto-temporo-parietal networks, suggesting a potential assessment avenue for understanding brain-behaviour associations in PD with electrophysiological task paradigms.

An Automated Approach to Examining Pausing in the Speech of People With Dementia.

Dementia is a common neurodegenerative condition involving the deterioration of cognitive and communication skills. Pausing in the speech of people with dementia is a dysfluency that may be used to signal conversational trouble in social interaction. This study aimed to examine the speech-pausing profile within picture description samples from people with dementia and healthy controls (HCs) within the DementiaBank database using the Calpy computational speech processing toolkit. Sixty English-speaking participants between the ages of 53 and 88 years (Mage = 67.43, SD = 8.33; 42 females) were included in the study: 20 participants with mild cognitive impairment, 20 participants with moderate cognitive impairment, and 20 HCs. Quantitative analysis shows a progressive increase in the duration of pausing between HCs, the mild dementia group, and the moderate dementia group, respectively.

Alterations to dual stream connectivity predicts response to aphasia therapy following stroke.

BACKGROUND: Predicting aphasia recovery is difficult due to a high variability in treatment response. Detailed measures of treatment response are compounded by a dearth of information that examine brain connections that contribute to clinical improvement. In this study we measure alterations to cortical connectivity pathways during a therapy paradigm to detect whether key brain connections that contribute to language recovery can be detected prior to therapy. METHODS: We conducted a case-control trial with twenty-three adults including eight adults with chronic, post-stroke aphasia. Aphasia patients underwent 12 naming therapy sessions over 4 weeks, consisting of semantic and phonological treatment approaches. High-density electroencephalography (128 channel EEG) was measured prior to therapy and immediately following treatment in patients with aphasia. Analysis via a dynamic causal modelling (DCM) was used to assess which cortical connections significantly correlated with therapy response. RESULTS: Altered cortical responses in aphasia patients measured bilaterally in a dual stream DCM connectivity model were predictive of treatment-induced improvement in naming. Pre-treatment DCM coupling (i.e., strength of cortical connections) significant correlated with naming improvement for items treated with semantic therapy, as indicated by increased connection strengths between left inferior parietal lobule (LIPL) and inferior frontal gyrus (LIFG, r = .63, pFDR = .016). In particular, the mediating role of contralateral regions significantly influences overall treatment improvement in the latter stages of stroke recovery. CONCLUSIONS: Our findings identify a potential means to stratify larger cohorts of patients in neurorehabilitation settings into distinct treatments that are tailored to their individual language deficit.

Cross-modal emotion recognition and autism-like traits in typically developing children.

The ability to explicitly recognize emotions develops gradually throughout childhood, and children usually have greater difficulty in recognizing emotions from the voice than from the face. However, little is known about how children integrate vocal and facial cues to recognize an emotion, particularly during mid to late childhood. Furthermore, children with an autism spectrum disorder often show a reduced ability to recognize emotions, especially when integrating emotion from multiple modalities. The current preliminary study explored the ability of typically developing children aged 7-9 years to match emotional tones of voice to facial expressions and whether this ability varies according to the level of autism-like traits. Overall, children were the least accurate when matching happy and fearful voices to faces, commonly pairing happy voices with angry faces and fearful voices with sad faces. However, the level of autism-like traits was not associated with matching accuracy. These results suggest that 7- to 9-year-old children have difficulty in integrating vocal and facial emotional expressions but that differences in cross-modal emotion matching in relation to the broader autism phenotype are not evident in this task for this age group with the current sample.

White noise facilitates new-word learning from context.

Listening to white noise may facilitate cognitive performance, including new word learning, for some individuals. This study investigated whether auditory white noise facilitates the learning of novel written words from context in healthy young adults. Sixty-nine participants were required to determine the meaning of novel words placed within sentence contexts during a silent reading task. Learning was performed either with or without white noise, and recognition of novel word meanings was tested immediately after learning and after a short delay. Immediate recognition accuracy for learned novel word meanings was higher in the noise group relative to the no noise group, however this effect was no longer evident at the delayed recognition test. These findings suggest that white noise has the capacity to facilitate meaning acquisition from context, however further research is needed to clarify its capacity to improve longer-term retention of meaning.

Conversational trouble and repair in dementia: Revision of an existing coding framework.

A decline in the effectiveness of everyday conversation is often observed for people with dementia. This study explored conversational trouble and repair between people with dementia residing in residential care and professional care staff. The aim was to examine the utility of an existing conversational trouble and repair framework by Watson, Carter and Chenery (1999) in a comparatively larger sample. Twenty conversations were coded for dementia-specific trouble and repair; however, the original framework could not adequately accommodate the variety of trouble and repair within the dataset. The data was subsequently used to inform a revised framework, which captures a wide spectrum of trouble and repair in dementia and offers more precise codes to researchers and clinicians working with this clinical population. Examples of divergent coding strategies between the original and revised framework are provided as well as examples of trouble and repair patterns observed in both carers and people with dementia.

Source activity during emotion processing and its relationship to cognitive impairment in Parkinson's disease.

BACKGROUND: Neural mechanisms contributing to an underlying cognitive impairment in Parkinson's disease (PD) are poorly understood. An effective method to probe cognitive processing deficits in PD is the examination of brain activity during emotional processes, particularly in explicit language emotion recognition contexts. METHODS: The present study utilised cortical source imaging of event related potentials (ERP) from electroencephalography (EEG) to evaluate valence judgements on negative and neutral target words in an automatic affective priming paradigm. Fifty non-demented PD patients, unmedicated for depression or anxiety, completed affective priming tasks during EEG monitoring. Cognitive impairment was measured using the validated Parkinson's Disease-Cognitive Rating Scale (PD-CRS). RESULTS: Results reveal that compared to healthy age-matched controls, PD patients demonstrate a reduced N400 activation during affective priming tasks in bilateral regions of the middle frontal gyrus (MFG), inferior parietal lobule (IPL) and, notably, have a late wave ERP component (LPP) in left MFG, present between 600 and 800 ms, following family-wise error correction (pFWE < 0.05). LPP in PD patients were significantly associated with PD-CRS scores. LIMITATIONS: Although affective priming paradigms are an effective means for various domains of cognition, it is not a focused cognitive behavioural test for cognitive dysfunction. Our study is thus limited to a surrogate measure of cognitive dysfunction via examination of emotional word processing cues. CONCLUSIONS: These findings suggest that source imaging methods with ERP paradigms in PD are effective in identifying delayed cognitive processes in PD.

Reading Development in Children With Cochlear Implants Who Communicate via Spoken Language: A Psycholinguistic Investigation.

Purpose This study sought to comprehensively examine the reading skills and subskills of children with cochlear implants (CIs) and gain insight into the processes underlying their early reading development. Method Fourteen 6- to 9-year-old children with CIs were assessed on a range of reading and spoken language measures. Their performances were compared to a control group of 31 children with normal hearing (NH) of the same chronological and mental age. Group differences were examined using t tests and regression modeling. Results Children with CIs performed significantly worse than children with NH on reading accuracy, phonological processing, and spoken language tasks. The predominant predictor of reading comprehension was word reading accuracy for the CI group and listening comprehension for the NH group. Word reading profiles were similar across groups, with orthographic and phonological processing skills both contributing significant variance. Conclusions Children with CIs demonstrated more early reading difficulties than their peers with NH. As predicted by the Simple View of Reading model, successful reading comprehension for all children related to skills in listening comprehension and word recognition. The CI group's increased reliance on word reading accuracy when comprehending written text may stem from reduced word recognition automaticity. Despite showing reduced reading accuracy, children with CIs appeared to draw on orthographic and phonological skills to a similar degree as children with NH when reading words in isolation.