ABSTRACT
Comparison of ketazolam given once-a-day with diazepam given three times a day and placebo given either once or 3 times a day in 101 anxious outpatients showed ketazolam to be significantly better than placebo in alleviating the symptoms of anxiety and, on several measures of efficacy, better than diazepam as well. Significantly fewer patients on ketazolam dropped out of the study due to ineffective medication than on the other 3 treatments. The incidence of side effects was lowest in the ketazolam group. Of particular note, drowsiness was reported twice as often by diazepam patients as by ketazolam patients.
Subject(s)
Anti-Anxiety Agents/therapeutic use , Benzodiazepines , Benzodiazepinones/therapeutic use , Diazepam/therapeutic use , Adolescent , Adult , Aged , Anti-Anxiety Agents/adverse effects , Anxiety Disorders/drug therapy , Anxiety Disorders/psychology , Benzodiazepinones/adverse effects , Diazepam/adverse effects , Double-Blind Method , Drug Administration Schedule , Humans , Middle Aged , Psychiatric Status Rating ScalesABSTRACT
Illegal drug use in a population of 3,807 junior high school students in a suburban area appeared strongly correlated with family instability, student personal problems, and low academic performance. Use of tranquilizers, amphetamines, and sedatives was often motivated by attempts at self-medication to reduce painful feelings. Over 14% of illegal users took an overdose with about half of them intentional. Illegal users and nonusers agreed that drug education programs and the threat of legal penalties had little influence in their decisions about drugs.
