ABSTRACT
The response of bone marrow cells of CBA mice injected with 22.2, 222 and 592 kBq/animal to additional gamma-irradiation (3 Gy) for testing purposes was evaluated using SCG (Comet assay). A decrease in induction of DNA damage right after additional gamma-irradiation was determined. It correlated with bone marrow cell quantity and the tail length before additional gamma-irradiation. The results support the suggestion about the activation of DNA repair in bone marrow cells under exposure to 90Sr in vivo.
Subject(s)
Bone Marrow Cells/radiation effects , DNA Damage/radiation effects , Animals , Comet Assay , DNA Repair , Gamma Rays , Mice , Mice, Inbred CBA , Strontium RadioisotopesABSTRACT
The material presented provides evidence that high nitrite doses have a various effect under the condition of external or internal radiation. Thus, nitrite protector properties were observed in male rats exposed to external radiation using the LD50/30 while following 90Sr exposure male rats of the same age showed a higher sensitivity to the radionuclide. The nitrite combined with optimum carcinogenic 90Sr dose had a potentiating effect on both life-span shortening and increase in osteosarcoma rate in the animals.
Subject(s)
Bone Neoplasms/etiology , Neoplasms, Radiation-Induced/etiology , Nitrites/toxicity , Osteosarcoma/etiology , Radiation Injuries, Experimental , Radiation-Protective Agents , Animals , Female , Lethal Dose 50 , Male , Nitrites/administration & dosage , Nitrites/pharmacology , Radiation Injuries, Experimental/mortality , Rats , Strontium Radioisotopes/administration & dosageABSTRACT
In experiments with rats the authors have assessed the development of remote effects of radiation (90Sr) combined with chronic exposure to chlorophos and lindane within a wide range of doses. It has been shown that chronically administered chlorophos and lindane have no carcinogenic and cocarcinogenic effects.
Subject(s)
Cocarcinogenesis , Hexachlorocyclohexane/toxicity , Neoplasms, Radiation-Induced , Osteosarcoma/etiology , Strontium Radioisotopes , Trichlorfon/toxicity , Animals , Female , Male , RatsABSTRACT
The experiments on rats exposed separately and in combination to radiation and chemical substances showed that the time of body pesticide intake (the total dose) was the leading factor affecting the phagocytosis indices. A daily pesticide dose had a credible impact on some indices. The combined effect was formed primarily due to chemical compounds. In general the effect could be regarded as less than additive though at some time it was additive and more than that.
