Effects of long-term construction noise on health of adult female Wistar rats.

The aim of this study was to investigate the influence of long-term building construction noise from refurbishment, which including vibration, on some physiological parameters and histopathological changes of organs of Wistar rats. Twenty 12 month old female rats were divided into two groups: rats group I (n = 10) were exposed to long-term construction noise and rats group II (n = 10) were kept under normal noise level. Study results revealed that long-term construction noise from building refurbishment has an influence on body weight, haematological and some serum biochemical parameters affects caecal microbiota, and causes histopathological changes in the organs of adult female Wistar rats. It was noticed that rats in group I exihibited significantly higher mean values for total protein, albumin and lower values for glucose, AST, ALT, blood urea nitrogen, haematological and caecal microbiota parameters than rats in group II. The most common pathologies were determined in the kidney, liver and lungs. Other observed pathologies were lymphadenopathy, catarrhal inflammation of the intestines, spleen hyperplasia and mammary gland adenofibroma. Single cases were subcutaneous fibroma in the thoracic region, abortus with uterine inflammation and thymus hyperplasia with formation of cysts were found.

Effect of age, hyperplasia and atrophy on collagen parameters in dog prostates.

The aim of this study was to examine the quantitative parameters of interstitial collagen in the normal and abnormal (hyperplasia, atrophy) prostates of dogs from 6 months to 11 years of age and older. Prostate specimens were fixed in formalin and processed for light microscopy with HE and Sirius Red. A histomorphometric study of collagen was performed using a computer-assisted image analysis system (Quantimet 520). In each section, under the capsule of prostate, except inflammatory tissue, the percentage volume of collagen, the perimeter of collagen area, and the number of fibers in the field of view were determined. The number of collagen fibers in the field of view and the perimeter of interstitial collagen in mature dog prostates decreased with age (p < 0.01). It was determined that the percentage volume moderately correlated with the amount of collagen fibers in the field of view (R = 0.34, p < 0.01) and markedly correlated with the collagen perimeter (R = 0.74, p < 0.01). The percentage volume of collagen in sexually immature dog prostates (up to 7-8 months of age) and in atrophic prostates was 36% and 44%, respectively. In case of hyperplasia, the percentage volume of collagen did not increase.