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1.
Transpl Int ; 26(8): 833-41, 2013 Aug.
Article in English | MEDLINE | ID: mdl-23782175

ABSTRACT

This 5 year observational multicentre study conducted in the Nord Italian Transplant programme area evaluated outcomes in patients receiving kidneys from donors over 60 years allocated according to a combined clinical and histological algorithm. Low-risk donors 60-69 years without risk factors were allocated to single kidney transplant (LR-SKT) based on clinical criteria. Biopsy was performed in donors over 70 years or 60-69 years with risk factors, allocated to Single (HR-SKT) or Dual kidney transplant (HR-DKT) according to the severity of histological damage. Forty HR-DKTs, 41 HR-SKTs and 234 LR-SKTs were evaluated. Baseline differences generally reflected stratification and allocation criteria. Patient and graft (death censored) survival were 90% and 92% for HR-DKT, 85% and 89% for HR-SKT, 88% and 87% for LR-SKT. The algorithm appeared user-friendly in daily practice and was safe and efficient, as demonstrated by satisfactory outcomes in all groups at 5 years. Clinical criteria performed well in low-risk donors. The excellent outcomes observed in DKTs call for fine-tuning of cut-off scores for allocation to DKT or SKT in high-risk patients.


Subject(s)
Graft Survival , Kidney Failure, Chronic/surgery , Kidney Transplantation , Kidney/pathology , Aged , Aged, 80 and over , Algorithms , Biopsy , Cadaver , Delayed Graft Function , Female , Humans , Italy , Kidney Transplantation/mortality , Male , Middle Aged , Retrospective Studies , Risk Factors , Tissue Donors , Treatment Outcome
2.
Exp Dermatol ; 20(12): 1025-7, 2011 Dec.
Article in English | MEDLINE | ID: mdl-21995456

ABSTRACT

To define the potential involvement of polymorphisms in the 3'untranslated region (3'UTR) of the prostaglandin synthetase-2 (PTGS-2) gene to non-melanoma skin cancer (NMSC) predisposition after transplantation, we screened for genetic variant, relevant parts of this region. It contains binding sites for trans-acting factors, an alternative polyadenylation site and putative target sequences for miRNAs. Variant +8473T>C did not appear to play a functional role in the regulation of gene expression in human keratinocyte-transfected cells. In addition to the well-known +8473T>C, we identified four polymorphisms: +8293G>C, +10259T>G, +10267G>A and +10335G>A. No allele frequency differences were observed between cases and controls neither for +8473T>C nor for any of the identified polymorphisms, suggesting that polymorphisms in the 3'UTR of the PTGS2 gene are rare and unlikely to represent risk factor for NMSC after transplantation.


Subject(s)
3' Untranslated Regions/genetics , Cyclooxygenase 2/genetics , Organ Transplantation/adverse effects , Skin Neoplasms/genetics , Bowen's Disease/etiology , Bowen's Disease/genetics , Carcinoma, Basal Cell/etiology , Carcinoma, Basal Cell/genetics , Carcinoma, Squamous Cell/etiology , Carcinoma, Squamous Cell/genetics , Gene Expression/genetics , Gene Frequency/genetics , Genotype , Humans , Keratoacanthoma/etiology , Keratoacanthoma/genetics , Polymorphism, Single Nucleotide/genetics , Skin Neoplasms/etiology
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