ABSTRACT
Human papillomavirus (HPV) infection is associated with genital malignancy and specific cutaneous malignancies. We report a case of an HPV-associated concurrent vulval intraepithelial neoplasia and periungual Bowen's disease in a young immunocompetent Afro-Caribbean woman with no known risk factors for either disease. HPV genotyping studies detected multiple alpha and beta papillomaviruses with concordance for HPV-34 [a high-risk (HR) mucosal type], and HPV-21 [an epidermodyslasia verruciformis (EV) type] in both vulval and finger tissue. Although the HR-mucosal viruses detected are likely to have a pathogenic role in vulval intraepithelial neoplasia, this is the first report of concordance for EV HPV types in both genital and nongenital skin premalignancies. This case, in the context of accumulating epidemiological and experimental data in cutaneous SCC, raises the question of whether EV HPV may contribute to vulval malignancy, and further study is merited.
Subject(s)
Bowen's Disease/virology , Fingers/virology , Papillomaviridae/isolation & purification , Papillomavirus Infections/virology , Skin Neoplasms/virology , Vulvar Neoplasms/virology , Adult , Female , HumansABSTRACT
This aim of this study was to undertake a retrospective analysis of the notes of all new patients who attended the joint vulval clinic between 1994 and 1997. One hundred and forty-five patients were seen, and data analysed for 133 (92%). The study identified the range of diagnoses seen; treatment modalities undertaken; and enabled comparisons to be made between our findings and those of other workers.
ABSTRACT
A prospective study was performed of 100 caesarean sections (31 elective, 69 emergency) to determine the incidence of blood splashes to the masks and goggles of surgeons, assistants and scrub nurses. The rate of blood splashes was 40% on surgeons' masks, 49.29% on surgeons' goggles, 31% on assistants' masks, 21.12% on assistants' goggles, 23.1% on scrub nurses' masks and 15.71% on scrub nurses' goggles. The use of masks and protective goggles is strongly recommended to avoid body fluid contamination and acquiring disease in obstetrics.
