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Bioorg Med Chem Lett
; 14(9): 2113-6, 2004 May 03.
Article
in English
| MEDLINE
| ID: mdl-15080990
ABSTRACT
The tertiary amide delta opioid agonist 2 is a potent antinociceptive agent. Compound 2 was metabolized in vitro and in vivo to secondary amide 3, a potent and selective micro opioid agonist. The SAR of a series of N-alkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides was examined.