1.
Antimicrob Agents Chemother
; 42(9): 2456-8, 1998 Sep.
Article
in English
| MEDLINE
| ID: mdl-9736585
ABSTRACT
Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum. Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.