ABSTRACT
The article presents findings from examination of 15 patients with cirrhosis of the liver complicated by encephalopathy. A study was made into the blood content of aminoacids and ammonia, which levels were found to have been raised in cirrhotic patients. The use of dufalac and nutriklinz dispelled clinical manifestations of encephalopathy normalizing the content of ammonia and modifying the aminoacid dysbalance at the expense of lowering of the blood concentration of cerebrotoxic aminoacids.
Subject(s)
Gastrointestinal Agents/therapeutic use , Lactulose/therapeutic use , Liver Cirrhosis/drug therapy , Adult , Amino Acids/blood , Ammonia/blood , Brain Diseases, Metabolic/drug therapy , Brain Diseases, Metabolic/etiology , Brain Diseases, Metabolic/metabolism , Drug Therapy, Combination , Female , Humans , Liver Cirrhosis/complications , Liver Cirrhosis/metabolism , Male , Middle Aged , Treatment OutcomeABSTRACT
Our objective in this study was investigation into the effectiveness of the enzymic preparation Kirshner Pancreal in 27 patients with chronic pancreatitis. It is shown that against the background of treatment with the above drug patients dispelled the pain syndrome and manifestations of the maldigestion syndrome. The described drug made for normalization of the blood serum content of beta-lipoproteins. The drug is well-tolerated by patients, no adverse effects were noted.
Subject(s)
Enzyme Therapy , Pancreatitis/drug therapy , Chronic Disease , Combined Modality Therapy , Drug Combinations , Enzymes/adverse effects , Female , Humans , Male , Pancreatitis/diagnosis , Tablets , Time FactorsABSTRACT
The indices for the gastric contents aggression and protection ratio returned to normal in patients with peptic ulcer and preulcerous condition during the treatment with smekta due to a decrease in proteolytic activity and increase in the synthesis of the mucus protective proteins. Monitoring of intragastric pH in the body of the stomach throughout 24 hours in patients with peptic ulcer of duodenal location revealed significant acid-neutralizing effect of smekta. Patients with nonspecific ulcerous colitis enjoyed freedom of side effects as a result of the use of salofalk and derived full therapeutic benefit from this treatment. Under the effect of smekta there occurred suppression of the growth of pathogenic proteolytic flora, improvement of qualitative properties of coli flora and growth of sugar-lytic flora in patients with intestinal dysbiosis. According to the data available, smekta strengthens the mucous barrier by improving the conformation of the mucus structural elements.
Subject(s)
Digestive System Diseases/drug therapy , Silicates/therapeutic use , Aminosalicylic Acids/therapeutic use , Animals , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Digestive System Diseases/physiopathology , Drug Evaluation , Drug Therapy, Combination , Gastric Acidity Determination , Gastric Juice/drug effects , Humans , Intestine, Small/drug effects , Intestine, Small/enzymology , Male , Mesalamine , Omeprazole/therapeutic use , Rats , Rats, Wistar , Silicates/pharmacology , Sodium-Potassium-Exchanging ATPase/drug effects , Sodium-Potassium-Exchanging ATPase/metabolismABSTRACT
A study of 179 patients with functional and organic diseases of the bile tract revealed that changes of the blood phospholipids and their spectra in the blood is observed at more early stages of the disease, functional pathology and that an increased PGE2/PGF2 indicates a deficit of polyunsaturated fatty acids and prevalence of the processes of break-up of prostaglandins over their synthesis.
Subject(s)
Biliary Tract Diseases/metabolism , Dinoprost/blood , Dinoprostone/blood , Phospholipids/analysis , Adolescent , Adult , Aged , Bile/analysis , Chronic Disease , Female , Humans , Male , Middle AgedABSTRACT
Functional and structural changes of the hepato-biliary system were assessed in 56 persons with different forms of chronic alcoholism. In patients with prenosological forms of chronic alcoholism despite the absence of clinical manifestations and functional disorders of the liver, phenomena of fatty infiltration of the liver were revealed by means of ultrasound examination. Patients with chronic alcoholism of grade II and III showed an increase of the activity of aminotransferases, increased values of the thymol test, hypoalbuminemia, disorders of lipid metabolism. Phenomena of chronic hepatitis and liver cirrhosis were revealed by ultrasound examination in these patients.
Subject(s)
Alcoholism/complications , Biliary Tract Diseases/diagnosis , Liver Diseases, Alcoholic/diagnosis , Ultrasonography , Biliary Tract Diseases/etiology , Clinical Enzyme Tests , Female , Humans , Liver/pathology , Male , Time FactorsABSTRACT
The level of bile acids was studied in the bile and feces in 119 patients with chronic alcoholism using thin-layer chromatography. The cholate-forming function of the liver was found to increase in patients with short alcohol anamnesis in chronic alcoholism. With advance of the alcohol anamnesis the number of patients with reduced cholate-forming function of the liver increased.
Subject(s)
Alcoholism/metabolism , Cholic Acids/biosynthesis , Liver/metabolism , Bile/analysis , Bile Acids and Salts/analysis , Cholic Acids/analysis , Chromatography, Thin Layer , Feces/analysis , HumansABSTRACT
The cholate-forming and cholesterol-excretory function of the liver was studied in patients with ulcer disease of the duodenum after different types of vagotomy--selective proximal vagotomy and selective proximal vagotomy with pyloroplasty. The patients revealed different degrees of disorders in the content of bile acids, their fractions, bile cholesterol as well as a dependence of these changes of the type of operation. The changes were more pronounced in patients undergoing selective proximal vagotomy as compared with those undergoing selective proximal vagotomy with pyloroplasty.
Subject(s)
Cholesterol/metabolism , Cholic Acids/biosynthesis , Duodenal Ulcer/physiopathology , Liver/physiopathology , Stomach Ulcer/physiopathology , Duodenal Ulcer/surgery , Female , Humans , Liver/metabolism , Male , Stomach Ulcer/surgery , VagotomyABSTRACT
Three groups of subjects were examined without complaints characteristic of involvement of the hepatobiliary system. In 11% of healthy persons disorders of the biochemical composition of bile were revealed, namely reduction of the level of bile acids and phospholipids, 23% changes in the ratio of bile acids and phospholipid fractions.
Subject(s)
Bile/analysis , Biliary Tract Diseases/diagnosis , Adolescent , Adult , Bile Acids and Salts/analysis , Cholesterol/analysis , Chronic Disease , Humans , Middle Aged , Phospholipids/analysisABSTRACT
The bile secretory function of the liver in patients with hyperlipoproteinemia complicated by atherosclerosis of the vessels of the lower extremities was studied. It was established, that irrespective of the type of hyperlipoproteinemia in patients, the impairement in the cholate-forming and cholesterin-excreting functions of the liver was present. This aggravated the course of atherosclerosis. The content of common bile acids in patients was, in average, 1-5-fold lower than in normal subjects. The more considerable decrease in the quantity of trihydroxycholanic acids when compared to the dihydroxycholanic ones indicates the inhibition of the processes of synthesis of the bile acids from cholesterin in the hepatocytes in patients with hyperlipoproteinemia.
