ABSTRACT
The antiviral activity of iodantipyrine was studied in outbred [correction of inbred] albino mice (weight 10-12 g) infected with the Absettarov strain of the tick-borne encephalitis virus. Iodantipyrine was administered per os or parenterally and the animals were observed for 21 days. A reliable therapeutic effect was produced in 60% of mice infected with 10 DL50 of tick-borne encephalitis virus which were given the drug per os in a dose of 50 mg/kg. Preventive administration of the drug was effective in 47% of the animals.
Subject(s)
Antipyrine/analogs & derivatives , Antiviral Agents/administration & dosage , Encephalitis, Tick-Borne/drug therapy , Animals , Antipyrine/administration & dosage , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Encephalitis, Tick-Borne/mortality , Encephalitis, Tick-Borne/prevention & control , Mice , Tilorone/administration & dosage , Time FactorsABSTRACT
The antiviral activity of iodantipyrine-4 belonging to the group of nonsteroid anti-inflammatory compounds was studied in inbred white mice of 10-12 g given a single subcutaneous injection of the Absettarov strain of tick-borne encephalitis virus. Iodantipyrine-4 in different doses was administered orally or parenterally, and the animals were observed for 21 days. In the group of mice infected with 10 LD50 of TBE virus which were treated with the drug orally in a dose of 50 mg/kg a reliable therapeutic effect was established in 60%, after parenteral injection in 53.4%. Prophylactic administration of the drug followed by challenge with 10 LD50 of virus was effective in 47% of mice. In the group of mice infected with 100 LD50 of the virus the therapeutic effect was observed in 38% and prophylactic in 30%. Iodantipyrine-4 was found to induce interferon production.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Antipyrine/analogs & derivatives , Antiviral Agents/therapeutic use , Encephalitis, Tick-Borne/drug therapy , Administration, Oral , Animals , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Antipyrine/administration & dosage , Antipyrine/therapeutic use , Antiviral Agents/administration & dosage , Dipyridamole/administration & dosage , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Encephalitis, Tick-Borne/blood , Encephalitis, Tick-Borne/prevention & control , Injections, Intraperitoneal , Interferon Inducers/administration & dosage , Interferon Inducers/therapeutic use , Interferon-alpha/blood , Male , MiceABSTRACT
EEE virus infection could be induced in white mice whose natural resistance to this virus had been reduced by immunosuppressive drugs such as: Adreson, Cyclophosphan and hydrocortisone.
