Multiple Drug-Resistant CLABSI from an Extremely Rare Bacterium, Chryseobacterium gleum.

Chryseobacterium gleum is a lactose nonfermenting Gram-negative bacillus (NFGNB) found in soil, plants, and some water sources but rarely implicated as a human pathogen. Its scarcity in the medical literature and resistance to numerous broad-spectrum antibiotics such as carbapenems, cephalosporins, and beta-lactam/lactamase inhibitors pose a diagnostic and therapeutic challenge. We present the first reported case, to the best of our knowledge, of sepsis from central line-associated blood stream infection from Chryseobacterium gleum in the United States.

Sulcular Modified Internal Labial Enhancement (SMILE) Technique for Gingival Augmentation.

The concept of periodontal root coverage has evolved over many years. To achieve high predictability a minimally invasive approach that reduces morbidity and can provide root coverage for multiple teeth in the same surgery is needed. This article describes a novel approach that represents a progression of the latest tunneling techniques in root coverage. The somewhat unique method utilizes fewer instruments than other similar techniques and incorporates the use of platelet-rich fibrin.

Ipilimumab- and Nivolumab-Induced Colitis Causing Severe Hypokalemia and QTc Prolongation.

Immune-mediated colitis is an uncommon but well-documented adverse event in patients receiving nivolumab or ipilimumab therapy. In this report, we present a 69-year-old man who developed severe hypokalemia and colitis with significant corrected Q-T segment (QTc) prolongation as a result of combination nivolumab-ipilimumab immunotherapy for clear cell renal cell carcinoma.

Luteolin Decreases Epidermal Growth Factor Receptor-Mediated Cell Proliferation and Induces Apoptosis in Glioblastoma Cell Lines.

Glioblastomas are a subtype of gliomas, which are the most aggressive and deadly form of brain tumours. The epidermal growth factor receptor (EGFR) is over-expressed and amplified in glioblastomas. Luteolin is a common bioflavonoid found in a variety of fruits and vegetables. The aim of this study was to explore the molecular and biological effects of luteolin on EGF-induced cell proliferation and the potential of luteolin to induce apoptosis in glioblastoma cells. In vitro cell viability assays demonstrated that luteolin decreased cell proliferation in the presence or absence of EGF. Immunoblots revealed that luteolin decreased the protein expression levels of phosphorylated Akt, mTOR, p70S6K and MAPK in the presence of EGF. Furthermore, our results revealed the ability of luteolin to induce caspase and PARP cleavages in glioblastoma cells in addition to promoting cell cycle arrest. Our results demonstrated that luteolin has an inhibitory effect on downstream signalling molecules activated by EGFR, particularly the Akt and MAPK signalling pathways, and provided a rationale for further clinical investigation into the use of luteolin as a therapeutic molecule in the management of glioblastoma.

Elucidating immunometabolic targets in glioblastoma.

Immunometabolism has recently emerged on the forefront of cancer research as a new avenue to potentially develop more effective and targeted treatment options. Several pathologically altered metabolic targets across various cancer types have been identified, including lactate in aerobic glycolysis; tryptophan in amino acid metabolism; and arginine in the urea cycle. Numerous advancements have improved our understanding of the dual function of these targets in influencing immune functions as an auxiliary function to their well-established metabolic role. This paper provides a comprehensive overview of immunometabolism research and attempts to provide insight into potential immunometabolic targets in glioblastoma for the purpose of future development and study of targeted therapies.

Osteotome sinus augmentation with less than 5 mm of native bone: a membrane visualization technique using a tapered platform-shifting implant.

As the usage of implants has increased, a trend in dental implantology is a move towards minimally invasive surgical techniques, which offer the advantages of both decreased healing time and lessened surgical morbidity. These improved procedures encourage more patients to consider this treatment. In addition, improved bone-grafting augmentation materials and enhanced implant surface design characteristics have resulted in reduced healing times. The authors describe and discuss the advantages of a modification to the classic osteotome sinus augmentation procedure. This technique, which requires less than 5 mm of native bone, uses demineralized freeze-dried bone allograft (DFDBA) and calcium sulfate as part of a composite graft, along with a tapered platform-shifting implant. Cone-beam computed tomography (CBCT) scans are also presented for diagnosis and evaluation after treatment of this minimally invasive technique yielding significant bone augmentation.

The changing treatment planning paradigm: save the tooth or place an implant.

With the high predictability of dental implants and the emphasis on evidence-based dentistry, treatment planning in periodontics and restorative dentistry is undergoing a paradigm shift. The algorithm of when to try to save periodontally involved teeth and when to extract and place dental implants is changing; however, the dental research has not yet provided definitive answers. This article discusses five main factors to consider during treatment planning and provides guidelines for considering extraction and implant placement or tooth-preservation procedures.

Calcium sulfate-augmented soft tissue root coverage adjacent to connective tissue grafting: a new technique.

A new technique using calcium sulfate augmentation for root coverage is described. Three consecutive cases were treated with the calcium sulfate technique adjacent to teeth being treated with the classic connective tissue grafting technique. Although this is only a pilot study, the postoperative results of the calcium sulfate-treated sites showed similar tissue shape, color, and contour to the adjacent grafted sites. The amount of root coverage was also similar.

Maxillary anterior esthetic extractions with delayed single-stage implant placement.

As a result of the high predictability of dental implantology, successful osseointegration is no longer the primary challenge. Rather, esthetics has emerged as the primary challenge. Hard and soft tissue ridge augmentation, performed either in preparation for later implant placement or concurrently with implant placement, has been described in the literature for the esthetic zone. These procedures are still evolving. If, however, ridge collapse can be prevented or minimized after tooth extraction, more predictable outcomes with better esthetics can be accomplished, along with fewer surgical procedures. This article describes a technique for esthetic extraction, as well as delayed esthetic single-stage implant placement, in the maxillary anterior sextant.