ABSTRACT
Human fibrinopeptides A and B (FAB) increased the arterial blood pressure, accelerated the heart rate and elevated permeability of capillaries, produced a vasodilatory effect, evoked positive chronotropic and inotropic action on the isolated heart and did not affect the coronary flow. They lowered the content of glycogen in the heart muscle. They did not affect the concentration of glucose and elevated the content of lactic acid and free fatty acids (FFA) in the blood. As FAB are present in large quantities in the blood during disseminated intravascular coagulation, they may play an essential role in pathology of the circulatory system of mammals.
Subject(s)
Cardiovascular System/drug effects , Fibrinogen/pharmacology , Fibrinopeptide A/pharmacology , Fibrinopeptide B/pharmacology , Animals , Blood Glucose/analysis , Blood Pressure/drug effects , Capillary Permeability/drug effects , Male , Rats , Rats, Inbred StrainsABSTRACT
Effects of fibrinopeptides A and B (FAB) in the rat circulation were examined after stimulation or inhibition of catecholamine system. FAB did not change the effects of noradrenaline and isoprenaline and increased the hypertensive action of dopamine. The effects of FAB on heart rate and blood pressure were absent in rats pretreated with propranolol and haloperidol respectively. Reserpine, alpha-methyl-p tyrosine and disulfiram diminished or abolished the effects of FAB. Apparently FAB can modify the function of adrenergic system in circulation either directly or indirectly.
