ABSTRACT
Serial measurements of allo- and autoimmune lymphocytotoxic antibodies (LCT-AB), circulating immune complexes (CIC) and heterophilic hemolysins were carried out over pregnancy weeks 24-40 in 63 pregnant women with small-for-date fetuses, 63 ones with other pregnancy complications, and in 15 ones with normal pregnancy. The mean allo- and auto-LCT-AB levels remained unchanged over the course of pregnancy and were virtually the same in all the examinees. CIC and heterophilic hemolysin levels were found growing in women with small-for-date fetuses starting from pregnancy week 28, as against the two reference groups. A direct relationship between abnormally high heterophilic hemolysin levels and blood rheology disorders could be traced. The incidence of unfavorable perinatal outcomes was increasing if heterophilic hemolysin levels surpassed 1.1 U optic density and the placenta was thin. These results permit considering the small-for-date fetus syndrome as a manifestation of immunity conflict in pregnancy.
Subject(s)
Autoimmune Diseases/immunology , Fetal Growth Retardation/etiology , Placenta/immunology , Placental Insufficiency/immunology , Adolescent , Adult , Antibodies, Heterophile/analysis , Antibodies, Heterophile/immunology , Antigen-Antibody Complex/analysis , Antigen-Antibody Complex/immunology , Autoantibodies/analysis , Autoantibodies/immunology , Autoimmune Diseases/blood , Autoimmune Diseases/complications , Female , Fetal Growth Retardation/immunology , Hemolysin Proteins/analysis , Hemolysin Proteins/immunology , Humans , Lymphocytes/immunology , Male , Marriage , Placental Insufficiency/blood , Placental Insufficiency/complications , PregnancySubject(s)
Antigen-Antibody Complex/analysis , Pregnancy, Prolonged , Pregnancy , Amniotic Fluid/immunology , Female , Humans , PrognosisABSTRACT
Examination of randomly selected pregnant women of the Kharkov city showed that the structure of marriage had undergone considerable changes during two successive generations. The number of endogamous marriages decreased, the percentage of marriages between persons of different nationalities being increased, which adequately reflects social-demographic processes taking place currently in all human populations. Judging by the data obtained, these changes in percentage of exogamous marriages do not considerably influence the probability of pregnancy failure which can be accounted for disturbed foeto-maternal immunological interrelations. No correlations between immunological indices and the degree of heterozygosity in women and the structure of marriages was demonstrated. The percentage of married couples with tainted heredity (spontaneous abortions, still-birth) was considerably higher among women with habitual pregnancy failure, which may testify to a certain role of hereditary predisposition to immune failure.
