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1.
Sci Total Environ ; 927: 172297, 2024 Jun 01.
Article in English | MEDLINE | ID: mdl-38588736

ABSTRACT

Soil pollution by As and Hg is a pressing environmental issue given their persistence. The intricate removal processes and subsequent accumulation of these elements in soil adversely impact plant growth and pose risks to other organisms in the food chain and to underground aquifers. Here we assessed the effectiveness of non-toxic industrial byproducts, namely coal fly ash and steelmaking slag, as soil amendments, both independently and in conjunction with an organic fertilizer. This approach was coupled with a phytoremediation technique involving Betula pubescens to tackle soil highly contaminated. Greenhouse experiments were conducted to evaluate amendments' impact on the growth, physiology, and biochemistry of the plant. Additionally, a permeable barrier made of byproducts was placed beneath the soil to treat leachates. The application of the byproducts reduced pollutant availability, the production of contaminated leachates, and pollutant accumulation in plants, thereby promoting plant development and survival. Conversely, the addition of the fertilizer alone led to an increase in As accumulation in plants and induced the production of antioxidant compounds such as carotenoids and free proline. Notably, all amendments led to increased thiolic compound production without affecting chlorophyll synthesis. While fertilizer application significantly decreased parameters associated with oxidative stress, such as hydrogen peroxide and malondialdehyde, no substantial reduction was observed after byproduct application. Thermal desorption analysis of the byproducts revealed Hg immobilization mechanisms, thereby indicating retention of this metalloid in the form of Hg chloride. In summary, the revalorization of industrial byproducts in the context of the circular economy holds promise for effectively immobilizing metal(loid)s in heavily polluted soils. Additionally, this approach can be enhanced through synergies with phytoremediation.


Subject(s)
Betula , Biodegradation, Environmental , Coal Ash , Soil Pollutants , Arsenic , Mercury , Mining , Fertilizers , Steel , Environmental Restoration and Remediation/methods , Soil/chemistry , Industrial Waste
2.
Chemosphere ; 301: 134645, 2022 Aug.
Article in English | MEDLINE | ID: mdl-35439496

ABSTRACT

Although different amendments have been used for the immobilization of metals and metalloids in contaminated soils, in most of them there are still important challenges that need to be faced in order to achieve an optimal result. In this work, a new material based on a carbon foam impregnated with goethite nanoneedles has been developed with the aim of evaluating its effect on the mobility and availability of As, Cd, Cu, Pb and Zn in an industrial soil. For this purpose, leaching, sequential extraction and phytotoxicity studies have been carried out. The results were compared with the same carbon foam without goethite impregnation. When the soil was treated with goethite-based carbon foam nanocomposite, the mobility of metal(loid)s was markedly reduced, with the exception of Zn, which showed moderate immobilization. The presence of acid groups on the surface of the carbon foam, together with a high surface area, led to a strong immobilization of pollutants. Moreover, the modification of the foams using goethite nanoneedles, imply that the novel nanocomposite obtained is effective to remediate simultaneously metal and metalloid-polluted soils, without any relevant effect on soil toxicity.


Subject(s)
Arsenic , Metals, Heavy , Nanocomposites , Soil Pollutants , Arsenic/analysis , Carbon , Iron Compounds , Metals , Metals, Heavy/analysis , Minerals , Soil , Soil Pollutants/analysis
3.
Talanta ; 150: 272-7, 2016 Apr 01.
Article in English | MEDLINE | ID: mdl-26838408

ABSTRACT

The goal of this work is to emphasize the reliability of the thermal desorption technique in identifying mercury species. The analysis of mercury species in solids is essential for assessing the risk of disposal or re-use of mercury-contaminated materials. This study evaluates the accuracy and reliability of thermal desorption as a technique for identifying mercury species by means of different thermo-desorption devices. For this purpose, mercury species present in samples related with coal utilization processes were identified. Three devices were compared for analyzing samples free of carbon or with a low carbon content (fly ashes, gypsums and soils), and a new equipment was developed to analyze samples with a high carbon content (coal). In spite of the fact that the first three devices employ different experimental conditions (i.e., heating rate, gas flow and carrier gas), the mercury species identified in the samples were comparable in all cases. The need for new equipment for mercury speciation in materials containing carbon was a consequence of interferences produced from the pyrolysis products of the organic matter. The new device consists of two furnaces and two gas inlets to allow thermal oxidation of organic pyrolysis products and the identification of mercury species in carbonaceous samples. This new approach offers the application of thermal desorption to mercury speciation in all types of materials contaminated with mercury.

4.
Arch Orthop Trauma Surg ; 136(2): 175-83, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26667622

ABSTRACT

OBJECTIVE: Meniscus injury is one of the causes of secondary osteoarthritis (OA). However, the role of meniscus is still unclear. Human meniscal distribution of cells and cartilage oligomeric matrix protein (COMP) and their changes in advanced OA were analyzed. PATIENTS AND METHODS: Thirty-one medial menisci from patients with knee OA that underwent a total knee arthroplasty were studied. Normal meniscal tissue was obtained from partial arthroscopic meniscectomy. Meniscal samples were processed for histology, immunohistochemistry and in situ hybridization, for cell assessment including density, active divisions, apoptosis, COMP distribution and proteoglycan content. RESULTS: Osteoarthritic menisci demonstrated areas of cell depletion and significant decrease in COMP immunostaining. Actively dividing cells were only found in the meniscectomy group, but not in the osteoarthritic group. Proteoglycan staining was less prominent in menisci from the osteoarthritis group. CONCLUSIONS: Our results show a decreased cell population, with low COMP and altered matrix organization in osteoarthritis menisci that suggest an altered meniscal scaffold and potential impairment of meniscal function. These meniscal changes may be associated with the development of knee osteoarthritis.


Subject(s)
Menisci, Tibial/pathology , Osteoarthritis, Knee/pathology , Aged , Aged, 80 and over , Apoptosis , Arthroplasty, Replacement, Knee , Calcinosis/pathology , Cartilage Oligomeric Matrix Protein/metabolism , Female , Humans , Immunohistochemistry , In Situ Hybridization , Male , Menisci, Tibial/metabolism , Middle Aged , Osteoarthritis, Knee/surgery , Proteoglycans/metabolism
5.
Appl Opt ; 54(31): 9143-51, 2015 Nov 01.
Article in English | MEDLINE | ID: mdl-26560566

ABSTRACT

We experimentally study the temporal dynamics of amplitude-modulated laser beams propagating through a water dispersion of graphene oxide sheets in a fiber-to-fiber U-bench. Nonlinear refraction induced in the sample by thermal effects leads to both phase reversing of the transmitted signals and dynamic hysteresis in the input-output power curves. A theoretical model including beam propagation and thermal lensing dynamics reproduces the experimental findings.

6.
Chemosphere ; 125: 191-7, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25585865

ABSTRACT

The aim of this study is to understand the different sorption behaviors of mercury species on activated carbons in the oxy-fuel combustion of coal and the effect of high quantities of water vapor on the retention process. The work evaluates the interactions between the mercury species and a series of activated carbons prepared from a macroalgae waste (algae meal) from the agar-agar industry in oxy-combustion atmospheres, focussing on the role that the high concentration of water in the flue gases plays in mercury retention. Two novel aspects are considered in this work (i) the impact of oxy-combustion gases on the retention of mercury by activated carbons and (ii) the performance of activated carbons prepared from biomass algae wastes for this application. The results obtained at laboratory scale indicate that the effect of the chemical and textural characteristics of the activated carbons on mercury capture is not as important as that of reactive gases, such as the SOx and water vapor present in the flue gas. Mercury retention was found to be much lower in the oxy-combustion atmosphere than in the O2+N2 (12.6% O2) atmosphere. However, the oxidation of elemental mercury (Hg0) to form oxidized mercury (Hg2+) amounted to 60%, resulting in an enhancement of mercury retention in the flue gas desulfurization units and a reduction in the amalgamation of Hg0 in the CO2 compression unit. This result is of considerable importance for the development of technologies based on activated carbon sorbents for mercury control in oxy-combustion processes.


Subject(s)
Charcoal/chemistry , Coal/analysis , Environmental Pollution/prevention & control , Mercury/chemistry , Oxygen/chemistry , Water/chemistry , Adsorption , Biomass , Gases/analysis , Nitrogen/chemistry , Oxidation-Reduction , Seaweed/chemistry
7.
Chemosphere ; 119: 459-465, 2015 Jan.
Article in English | MEDLINE | ID: mdl-25102829

ABSTRACT

The speciation of mercury is currently attracting widespread interest because the emission, transport, deposition and behaviour of toxic mercury species depend on its chemical form. The identification of these species in low concentrations is no easy task and it is even more complex in coal combustion products due to the fact that these products contain organic and mineral matter that give rise to broad peaks and make it difficult to carry out qualitative and quantitative analysis. In this work, a solution to this problem is proposed using a method based on thermal desorption. A sequential extraction procedure was employed for the comparison and validation of the method developed. Samples of fly ashes and soils were analyzed by both of these methods, and thermal desorption was found to be an appropriate technique for mercury speciation. Even in the case of low mercury contents, recovery percentages were close to 100%. The main mercury species identified in the samples studied were HgS and, to a lesser extent, HgO and HgSO4. In addition, although the presence of mercury complexes cannot be demonstrated, the desorption behaviour and sequential extraction results suggest that this element might be associated with the mineral matrix or with carbon particles in some of the solids.


Subject(s)
Coal Ash/chemistry , Coal , Environmental Pollutants/analysis , Hot Temperature , Mercury/analysis , Soil Pollutants/chemistry , Carbon/chemistry , Mercury/isolation & purification
8.
Knee ; 20(6): 476-81, 2013 Dec.
Article in English | MEDLINE | ID: mdl-24035248

ABSTRACT

BACKGROUND: Knee osteoarthritis mainly affecting the lateral facet of the patella, especially in young patients, is a definite challenge to the surgeon. Our purpose was to investigate the long-term outcome of a simple operation such as the partial lateral facetectomy on middle-aged to elderly patients with predominant lateral patellofemoral osteoarthritis. METHODS: A retrospective, long-term study of 39 knees (28 females, mean aged at surgery 61yearsold) with a minimum follow-up of 10years was performed. Evaluations included preoperative and postoperative questionnaires, physical examinations, and radiographs. RESULTS: The main outcomes included the initial anterior pain relief, with higher scores using the Knee Society Score (that improved in 84% of the knees), and the eventual failure of the technique, including percentage of patients that required secondary total knee replacement (30% of the knees). CONCLUSION: Partial lateral facetectomy aiming to decrease the high pressure in the lateral facet of the patella confirmed frequent pain relief. This surgical procedure being minimally invasive, relatively simple, and effective in selected patients, is a valid early alternative to more complex operations and does not preclude further reconstructive surgery in case of disease progression.


Subject(s)
Osteoarthritis, Knee/surgery , Osteotomy/methods , Patellofemoral Joint/physiopathology , Patellofemoral Joint/surgery , Range of Motion, Articular/physiology , Age Factors , Aged , Cohort Studies , Female , Follow-Up Studies , Humans , Male , Middle Aged , Minimally Invasive Surgical Procedures/methods , Osteoarthritis, Knee/diagnostic imaging , Osteoarthritis, Knee/physiopathology , Pain Measurement , Pain, Postoperative/physiopathology , Patellofemoral Joint/diagnostic imaging , Postoperative Care/methods , Radiography , Recovery of Function , Retrospective Studies , Risk Assessment , Sex Factors , Time Factors , Treatment Outcome
9.
Talanta ; 114: 318-22, 2013 Sep 30.
Article in English | MEDLINE | ID: mdl-23953477

ABSTRACT

The ability to accurately determine metal mercury content and identify different mercury species in solid samples is essential for developing remediation and control strategies. The aim of the present study is to characterize mercury compounds based on thermal desorption. For this purpose a series of samples was prepared and the operational parameters-heating velocity, carrier gas-were optimized. Fifteen commercial mercury compounds were analyzed for use as fingerprints. The results of the study show that the identification of mercury species by the method of thermal desorption is possible. The temperature of desorption increased according to the following order HgI2

Subject(s)
Environmental Pollutants/analysis , Mercury Compounds/analysis , Adsorption , Environmental Pollutants/chemistry , Hot Temperature , Mercury Compounds/chemistry , Silicon Dioxide/chemistry
10.
J Hazard Mater ; 244-245: 70-6, 2013 Jan 15.
Article in English | MEDLINE | ID: mdl-23246942

ABSTRACT

The control of soluble metal species in the sub-product leachate generated in electricity production processes is of great concern from an environmental and health point of view. Unlike fly ash, the leaching behaviour of char materials has received little attention. Yet, these solids are captured together with fly ashes in the particle control devices of power plants and are emitted in the same way as by-products. The present study was carried out using two char samples: (i) a raw char and (ii) the same type of char employed in a previous study so that it could serve as a sorbent for mercury species in gas phase. The char samples were by-products (residues) that had been generated during the gasification of plastic and paper waste. The leachates were analyzed for the following elements: Al, Ca, Si, Mg, Ba, Cu, Ni, Pb, Zn, Mo and Hg. In addition, geochemical modelling of the leaching test results was employed to identify the underlying chemical processes that led to the release of toxic elements. The results showed that at alkaline pH values, sorption on the solid surfaces of the char was negligible due to the inorganic complexation of cations in the solution. When the char was used as mercury sorbent slight changes occurred on the reactive surface resulting in the modification of the binding of some elements. As the pH increased, complexation with dissolved organic matter played a more important role in the case of some elements such as Cu because of the greater concentration of dissolved organic matter in solution.


Subject(s)
Environmental Pollutants/chemistry , Industrial Waste , Metals/chemistry , Models, Theoretical , Adsorption , Air Pollution/prevention & control , Hydrogen-Ion Concentration , Paper , Plastics , Power Plants
11.
J Environ Manage ; 98: 23-8, 2012 May 15.
Article in English | MEDLINE | ID: mdl-22325640

ABSTRACT

The combustion of coal can result in trace elements, such as mercury, being released from power stations with potentially harmful effects for both human health and the environment. Research is ongoing to develop cost-effective and efficient control technologies for mercury removal from coal-fired power plants, the largest source of anthropogenic mercury emissions. A number of activated carbon sorbents have been demonstrated to be effective for mercury retention in coal combustion power plants. However, more economic alternatives need to be developed. Raw biomass gasification chars could serve as low-cost sorbents for capturing mercury since they are sub-products generated during a thermal conversion process. The aim of this study was to evaluate different biomass gasification chars as mercury sorbents in a simulated coal combustion flue gas. The results were compared with those obtained using a commercial activated carbon. Chars from a mixture of paper and plastic waste showed the highest retention capacity. It was found that not only a high carbon content and a well developed microporosity but also a high chlorine content and a high aluminium content improved the mercury retention capacity of biomass gasification chars. No relationship could be inferred between the surface oxygen functional groups and mercury retention in the char samples evaluated.


Subject(s)
Air Pollutants/isolation & purification , Air Pollution/prevention & control , Charcoal/chemistry , Mercury/isolation & purification , Biomass , Power Plants
12.
Chemosphere ; 85(4): 565-70, 2011 Oct.
Article in English | MEDLINE | ID: mdl-21764100

ABSTRACT

This paper evaluates the speciation and partitioning of mercury in two Spanish pulverised coal combustion power plants (PP1 and PP2), equipped with wet limestone-based flue gas desulphurisation facilities (FGD) operating with forced oxidation and re-circulation of FGD water streams. These plants are fed with coal (PP1) and coal/pet-coke blends (PP2) with different mercury contents. The behaviour, partitioning and speciation of Hg were found to be similar during the combustion processes but different in the FGD systems of the two power plants. A high proportion (86-88%) of Hg escaped the electrostatic precipitator in gaseous form, Hg2+ being the predominant mercury species (68-86%) to enter the FGD. At this point, a relatively high total Hg retention (72% and 65%) was achieved in the PP1 and PP2 (2007) FGD facilities respectively. However, during the second sampling campaign for PP2 (2008), the mercury removal achieved by the FGD was much lower (26%). Lab-scale tests point to liquid/gas ratio as the main parameter affecting oxidised mercury capture in the scrubber. The partitioning of the gaseous mercury reaching the FGD system in the wastes and by-products differed. In the low mercury input power plant (PP1) most of the mercury (67%) was associated with the FGD gypsum. Moreover in PP2 a significant proportion of the gaseous mercury reaching the FGD system remained in the aqueous phase (45%) in the 2007 sampling campaign while most of it escaped in 2008 (74%). This may be attributed to the scrubber operating conditions and the different composition and chemistry of the scrubber solution probably due to the use of an additive.


Subject(s)
Air Pollutants/analysis , Mercury/analysis , Power Plants/instrumentation , Air Pollutants/isolation & purification , Calcium Carbonate/chemistry , Environmental Monitoring , Mercury/isolation & purification , Oxidation-Reduction , Spain
13.
Arch Orthop Trauma Surg ; 131(8): 1167-76, 2011 Aug.
Article in English | MEDLINE | ID: mdl-21674258

ABSTRACT

INTRODUCTION: Secondary knee osteoarthritis (OA) is currently associated with meniscal injuries, but the pathogenesis is unclear. We analyzed the distribution of cells and cartilage oligomeric matrix protein (COMP) and its changes in the early stages of degeneration in meniscus. METHOD: Ten New Zealand rabbits underwent anterior cruciate ligament (ACL)-transection of the right knee-joint. Left knee-joints were used as controls. The animals were killed at 4 and 12 weeks. Gross injuries in meniscus and articular cartilage were scored. Meniscal tissues were immunostained with a specific antibody against COMP, with Ki-67, using TUNEL-assay and alcian blue stain. The number of cells was counted. RESULTS: At 4 weeks post-ACL-transection, 2/5 of the operated knees showed articular damages and medial menisci tears. Menisci showed a weak increase of cells, higher in cells under division and an increase of apoptosis, COMP and proteoglycans. At 12 weeks, 5/5 of the medial menisci and 2/5 of lateral menisci presented tears, and osteoarthritic changes were seen in the cartilage of all the operated knees. Meniscal cells reverted to normal number, while active cell division decreased below normal, apoptotic events were still high, COMP remained elevated, and glycosaminoglycans were even more elevated. CONCLUSION: Extracellular matrix changes and altered cell distribution occur early in the degenerative meniscus. There is a close relationship between changes in the articular cartilage and the menisci at the onset of secondary OA.


Subject(s)
Extracellular Matrix Proteins/metabolism , Glycoproteins/metabolism , Knee Injuries/metabolism , Menisci, Tibial/metabolism , Osteoarthritis, Knee/etiology , Animals , Anterior Cruciate Ligament/metabolism , Apoptosis , Ki-67 Antigen/metabolism , Knee Injuries/pathology , Male , Matrilin Proteins , Menisci, Tibial/pathology , Rabbits
14.
Rev. esp. investig. quir ; 14(1): 9-14, ene.-mar. 2011. ilus
Article in English | IBECS | ID: ibc-89306

ABSTRACT

An experimental study was designed to determine the impact of the instability in the rabbit knee.Ten mature white New Zealand male rabbits were studied. Anterior cruciate ligament-transection of the right knee joint was performed. Animals were sacrificed at 4 weeks (group 1: five animals) and 12 weeks (group 2: five animals) after the surgery. Left knee joints were used as controls. Gross injuries in articular cartilage and in menisci were scored. Forty percent of the knees from the group 1 showed fibrillation. In the group 2, all the knees were damaged and 2/5 showed full-thickness erosion. Tears were observed in 2 internal menisci from the group 1 and in 2 external menisci and 5/5 internal menisci from the group 2. The earliest point of significantly higher incidence of knee damage was 3 months post injury. Therefore, when an anterior cruciate ligament reconstruction is indicated it should carry out as soon as possible (AU)


No disponible


Subject(s)
Animals , Rabbits , Anterior Cruciate Ligament/surgery , Osteoarthritis, Knee/surgery , Anterior Cruciate Ligament/injuries , Joint Instability/surgery , Disease Models, Animal
15.
J Hazard Mater ; 173(1-3): 450-4, 2010 Jan 15.
Article in English | MEDLINE | ID: mdl-19762148

ABSTRACT

The aim of this work was to evaluate the stability of arsenic and selenium species retained in a lime/limestone mixture obtained by using limestone as a sorbent for gas cleaning in a coal gasification atmosphere. It was found that the stability of arsenic and selenium species produced by the gas-solid reactions with lime/limestone may be affected by their exposure to air and by their contact with water. The results confirm the conclusions of a previous work in which Ca(AsO(2))(2) and CaSe was postulated as the products of the reaction between the arsenic and selenium species present in a coal gasification atmosphere with lime/limestone. Moreover it was proved that the compounds (Ca(AsO(2))(2) and CaSe) may undergo transformations when the sorbents post-retention are stored or disposed of in air. From the results obtained by XAFS it was possible to identify the Ca(3)(AsO(4))(2) produced by the oxidation of the Ca(AsO(2))(2) on the sorbent surface. The XAFS results for selenium showed that the CaSe formed on the sorbent was transformed to form several species, but mainly elemental Se. These changes in the speciation of arsenic and selenium may explain the behavior of the sorbent post-retention during the water solubility test. Although the selenium compounds and the products that may originate from their decomposition in water are not toxic, in the case of arsenic, species like Ca(AsO(2))(2) and Ca(3)(AsO(4))(2) may lixiviate, and generate toxic arsenic compounds in solution that could pose a risk when the sorbent is finally disposed of.


Subject(s)
Air Pollutants, Occupational/analysis , Arsenicals/chemistry , Calcium Carbonate/chemistry , Coal , Selenium Compounds/chemistry , Adsorption , Oxidation-Reduction , Solubility , Temperature , Thermodynamics , Water/chemistry , X-Ray Absorption Spectroscopy , X-Ray Diffraction
16.
Environ Sci Technol ; 43(4): 1078-85, 2009 Feb 15.
Article in English | MEDLINE | ID: mdl-19320161

ABSTRACT

The phasing out of leaded gasoline in many countries around the world at the end of the last millennium has resulted in a complex mixture of lead sources in the atmosphere. Recent studies suggest that coal combustion has become an important source of Pb in aerosols in urban and remote areas. Here, we report lead concentration and isotopic composition for 59 coal samples representing major coal deposits worldwide in an attempt to characterize this potential source. The average concentration in these coals is 35 microg Pb g(-1), with the highest values in coals from Spain and Peru and the lowest in coals from Australia and North America. The 206Pb/207Pb isotope ratios range between 1.15 and 1.24, with less radiogenic Pb in coals from Europe and Asia compared to South and North America. Comparing the Pb isotopic signatures of coals from this and previous studies with those published for Northern and Southern Hemisphere aerosols, we hypothesize that coal combustion might now be an important Pb source in China, the eastern U.S., and to some extent, in Europe but not as yet in other regions including South Africa, South America, and western U.S. This supports the notion that "old Pb pollution" from leaded gasoline reemitted into the atmosphere or long-range transport (i.e., from China to the western U.S.) is important. Comparing the isotope ratios of the coals, the age of the deposits, and Pb isotope evolution models for the major geochemical reservoirs suggests that the PbIC in coals is strongly influenced by the depositional coal forming environment.


Subject(s)
Aerosols/analysis , Coal/analysis , Lead/analysis , Geologic Sediments/chemistry , Isotopes , Radiometric Dating
17.
Opt Lett ; 33(8): 827-9, 2008 Apr 15.
Article in English | MEDLINE | ID: mdl-18414546

ABSTRACT

We report a change from sub- to superluminal propagation upon increasing the modulation frequency of an amplitude-modulated 1,550 nm signal when propagating through highly doped erbium fibers pumped at 980 nm. We show that the interplay between the pump absorption and the pump-power broadening of the spectral hole induced by coherent population oscillations may drastically affect the fractional advancement or delay of the signal for the considered fibers.

18.
Rev. senol. patol. mamar. (Ed. impr.) ; 19(2): 46-49, abr.-jun. 2006. tab
Article in Es | IBECS | ID: ibc-050343

ABSTRACT

Objetivo: La afectación de los ganglios axilares constituyeel principal factor pronóstico en cáncer de mama en cuantosupervivencia global. El propósito de este trabajo es el de presentarlos resultados de la primera fase de realización de labiopsia del ganglio centinela en cáncer de mama en nuestrocentro.Métodos: Se incluyó un total de 50 pacientes a las que serealizó la biopsia del ganglio centinela, seguida de linfadenectomíade los niveles I y II. Las indicaciones fueron tumor inferiora 2,5 cm de diámetro sin sospecha de afectación axilar,pacientes con carcinoma ductal in situ extenso y sin quimioterapiaprevia.Resultados: La tasa de detección general fue del 98%.Hubo un falso negativo. Se encontraron micrometástasis entres pacientes.Conclusión: La biopsia del ganglio centinela es un métodofiable para determinar el estado de los ganglios linfáticosregionales en pacientes con cáncer de mama


Objective: The status of the axilla is the single most importantprognostic indicator of overall survival in patients withbreast cancer. The aim of this study was to validate sentinelnode biopsy for axillary staging after the initial learning phase.Methods: A total of 50 patients, who had standard sentinelnode biopsy followed by level I and II axillary clearance,were recruited prospectively. Accepted indications were tumorless than 2,5 cm without suspicious findings in the axilla, patientswith large ductal carcinoma in situ and patients withoutpreoperative chemotherapy.Results: The overall detection rate was 98 per cent. Therewas one false negative. Micrometastases were found in threepatients.Conclusion: The sentinel node biopsy is a reliable methodfor determining the status of the regional lymph nodes in patientswith breast cancer


Subject(s)
Female , Adult , Middle Aged , Humans , Sentinel Lymph Node Biopsy , Radiopharmaceuticals , Technetium , Breast Neoplasms/pathology , Breast Neoplasms , Lymph Node Excision , Biopsy, Fine-Needle , Prospective Studies , Reproducibility of Results
19.
J Hum Hypertens ; 19(5): 401-6, 2005 May.
Article in English | MEDLINE | ID: mdl-15729378

ABSTRACT

Brachial-ankle pulse wave velocity (baPWV) is a promising technique to assess arterial stiffness conveniently. However, it is not known whether baPWV is associated with well-established indices of central arterial stiffness. We determined the relation of baPWV with aortic (carotid-femoral) PWV, leg (femoral-ankle) PWV, and carotid augmentation index (AI) by using both cross-sectional and interventional approaches. First, we studied 409 healthy adults aged 18-76 years. baPWV correlated significantly with aortic PWV (r = 0.76), leg PWV (r = 0.76), and carotid AI (r = 0.52). A stepwise regression analysis revealed that aortic PWV was the primary independent correlate of baPWV, explaining 58% of the total variance in baPWV. Additional 23% of the variance was explained by leg PWV. Second, 13 sedentary healthy men were studied before and after a 16-week moderate aerobic exercise intervention (brisk walking to jogging; 30-45 min/day; 4-5 days/week). Reductions in aortic PWV observed with the exercise intervention were significantly and positively associated with the corresponding changes in baPWV (r = 0.74). A stepwise regression analysis revealed that changes in aortic PWV were the only independent correlate of changes in baPWV (beta = 0.74), explaining 55% of the total variance. These results suggest that baPWV may provide qualitatively similar information to those derived from central arterial stiffness although some portions of baPWV may be determined by peripheral arterial stiffness.


Subject(s)
Blood Flow Velocity/physiology , Blood Pressure/physiology , Brachial Artery/physiology , Tibial Arteries/physiology , Adolescent , Adult , Aged , Ankle/blood supply , Arteriosclerosis/etiology , Arteriosclerosis/physiopathology , Blood Pressure Determination/methods , Carotid Artery, Common/physiology , Compliance , Cross-Sectional Studies , Exercise/physiology , Female , Femoral Artery/physiology , Humans , Japan , Male , Middle Aged , Plethysmography , Predictive Value of Tests , Pulse , Reference Values , Rest/physiology , Risk Factors , Supine Position/physiology , United States
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