ABSTRACT
We present feasibility, toxicity and efficacy results of an intensified six-cycle ChlVPP/ABVVP regimen in advanced Hodgkin lymphoma (HL). From February 2004 to August 2007, 82 consecutive eligible patients were enrolled. According to the Hasenclever index, 64 patients (78%) were considered at low risk, 15 (18%) at intermediate and 3 (4%) at high risk. The most relevant toxicity was haematological: grade 3-4 neutropenia occurred in 32% of patients, grade 3-4 anaemia in 26% of patients. Severe infections and febrile neutropenia were observed in 8% of patients. With a median follow-up of 35 months (range 12-55), the three-year freedom from treatment failure (FFTF) and overall survival (OS) were 75% (95% CI 65%-86%) and 94% (95% CI 87%-99%), respectively. The intensified ChlVPP/ABVVP regimen in advanced HL is effective, does not seem to differ from standard regimens in terms of FFTF and OS and showed a favourable toxicity profile.
Subject(s)
Antibodies, Monoclonal/pharmacology , Chlorambucil/pharmacology , Lymphoma, Non-Hodgkin/drug therapy , T-Lymphocyte Subsets/drug effects , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal, Murine-Derived , Antineoplastic Agents/therapeutic use , CD4-Positive T-Lymphocytes , CD8-Positive T-Lymphocytes , Chlorambucil/therapeutic use , Humans , Killer Cells, Natural , Lymphocyte Count , Lymphoma, Non-Hodgkin/immunology , RituximabSubject(s)
Plant Extracts/immunology , Plant Proteins/adverse effects , Allergens/adverse effects , Allergens/isolation & purification , Antibodies, Anti-Idiotypic/blood , Antigens, Plant , Food Hypersensitivity/blood , Food Hypersensitivity/diagnosis , Food Hypersensitivity/etiology , Humans , Skin TestsABSTRACT
A new test was developed specifically to detect mite antigens in house-dust. It uses a nitrocellulose dipstick spotted with specific antimite antibodies that act as a capture matrix; the same antibodies act as a detecting reagent when conjugated with colloidal dye particles. Aclotest is a 1-step assay, where a spotted dipstick is placed in a tube containing the detecting reagent and the house-dust sample. No instrumentation or previous extraction procedure of the sample is required, and the test response is visible as a colored spot, after 1 h incubation. The sensitivity and specificity of the new test were compared with those of Acarex and Der p1/Der f1 ELISA tests.
