[The Tobacco Smoking of Pregnant Women: the Role of Psycho-Social Factors].

The tobacco smoking of women during pregnancy and breast feeding represents a significant danger to public health. During pregnancy, the WHO recommends to abstain from cigarettes smoking. In spite of extensive information concerning related to smoking dangers to health of women and fetus, certain females continue to smoke during all pregnancy. The purpose of review is to identify and systematize existing data concerning prevalence, factors and modes of prevention tobacco smoking among pregnant females. In Russia, prevalence of tobacco smoking is at the level of highest European indices though in-land territorial differences are observed. The psycho-social factors significantly contribute to prevalence of smoking among pregnant women. The main social factors of tobacco smoking of pregnant women are low social economic status, unplanned pregnancy, smoking of representatives of the closest social environment (members of family and husband). The leading psychological factors effecting on success of smoking women to quit are psychological well-being, supporting relationship with significant others, high perceptible risks of smoking.

[Lipoilcarnosine: synthesis, study of physico-chemical and antioxidant properties, biological activity]. / Lipoilkarnozin: sintez, izuchenie fiziko-khimicheskikh i antioksidantnykh svoistv, biologicheskaia aktivnost'.

Synthesis of lipoilcarnosine (LipC) - a conjugated molecule based on two natural antioxidants, carnosine and a-lipoic acid, is described. Its physico-chemical, antioxidant properties and biological activity are characterized. According to reversed-phase HPLC with a UV detector, purity of the final product was 89.3%. The individuality of the obtained sodium salt of LipC was confirmed by tandem HPLC-mass spectrometry. High resistance of LipC to hydrolysis with serum carnosinase was demonstrated. The antioxidant activity of LipC measured by reaction with the formation of thiobarbituric acid reacting substances and kinetic parameters of iron-induced chemiluminescence was higher than that of carnosine and lipoic acid. LipC did not affect viability of SH-SY5Y human neuroblastoma culture cells, differentiated towards the dopaminergic type, at concentrations not exceeding 5 mM. At the concentration range of 0.1-0.25 mM LipC protected neuronal cells against 1-methyl-4-phenylpyridinium (MPP + )-induced toxicity.

[Alexithymia in patients with left-hemispheric cerebral infarction in the late recovery period]. / Aleksitimiya u bol'nykh s infarktom golovnogo mozga levopolusharnoi lokalizatsii v pozdnem vosstanovitel'nom periode.

AIM: To study emotional status, including alexithymia, anxiety and depression, in patients with cerebral infarction in the area of the middle cerebral artery (on the left side) in the late recovery period and to develop a method for correction of the damage. MATERIAL AND METHODS: The study included 30 patients with cerebral infarction in the area of the middle cerebral artery (on the left side). A comparison group consisted of 10 patients with chronic brain ischemia. RESULTS AND CONCLUSION: The results have demonstrated the correlation between the level of alexithymia and the severity of neurological deficit, sex-related level of anxiety and depression. The cerebral infarction impacts on the level of alexithymia. Alexithymia in patients with cerebral infarction affects the adequate self-esteem of physical and mental condition that may complicate the rehabilitation of these patients and demands correction as a combination of pharmacotherapy and psychotherapeutic intervention.

[Immunomorphological features of chronic tonsillitis].

The objective of the present work was to overview current concepts of immunology and pathological morphology of chronic tonsillitis. Morphological aspects of embryological development of palatine tonsils are discussed in conjunction with their participation in the formation of the immune response. Morphological and immunological peculiarities of the pathological process in chronic tonsillitis are described. It is concluded that otorhinolaryngologists must in due time identify indications for radical surgical sanitation of the pockets of chronic infection by means of bilateral tonsillectomy.

Effects of ectopic pacing on repolarization of the chicken left ventricle.

Effects of ectopic pacing on left ventricular repolarization were studied in six anesthetized open-chest chickens. In each animal, unipolar electrograms were acquired from as many as 98 sites with 14 plunge needles (seven transmural locations between epicardium and endocardium in each needle). Activation-recovery intervals (ARIs), corrected to the cycle length, were used for estimating repolarization. At baseline, the nonuniform ARI distribution in the left ventricle resulted in the apicobasal differences being greater than the transmural gradient. Nonuniform ARI prolongation caused by ectopic pacing resulted in decreasing the transmural repolarization gradient and increasing the differences in the apex-to-base direction. The basal, but not apical transmural differences contributed to the total left ventricular transmural gradient. The total left ventricular apicobasal gradient was contributed by the apicobasal differences in mid-myocardial and subendocardial layers more than in subepicardial ones. Thus, in in situ chicken hearts, the transmural and apicobasal ARI gradients exist within the left ventricle with the shortest ARIs in the basal subepicardium and the longest ARIs in the subendocardium of the apical and middle parts of the left ventricle. Apicobasal compared to transmural heterogeneity of local repolarization properties contributes more to the total left ventricular repolarization gradient.

[The role of bacteriological examination in diagnosis of chronic tonsillitis].

A bacteriological examination was made in 105 patients with various forms of chronic tonsillitis. Eighteen cultures of beta-hemolytic streptococcus (BHSA) were isolated from 36 patients with paratonsillar abscesses. BHSA seeding in paratonsillar abscess was 50.0%. Eight BHSA cultures were isolated from 69 patients with chronic tonsillitis. BHSA seeding in chronic tonsillitis was 11.6%. Adequate set of culture media for BHSA growth was optimized. The technique of the sample collection from tonsillar lacunes was improved. The significance of bacteriological diagnosis of chronic tonsillitis increases considerably due to optimization of out- and intralaboratory tests at the preanalytic stage of the study.

[Correlation in the of the process of cardiac ventricle intramural depolarization and distribution of cardioelectric field potentials of the dog Canis familiaris].

Based on a multichannel synchronous mapping of heart electric potentials, the sequence in time of the ventricle myocardium depolarization was compared with dynamics of distribution of cardioelectric potentials on the body surface in a dog. The cardioelectric field on the dog body surface at the period of the initial ventricular activity has been shown to be characterized by the presence of two inversions of the mutual disposition of areas of positive and negative potentials. Contribution to formation of distribution of the cardioelectric potentials on the body surface at each moment of the period of initial ventricular activity was made by all myocardial layers involved by excitation.

[Remote postoperative results of various surgical methodologies and the postop status of maxillary sinuses]. / Sostoianie verkhnecheliustnykh pazukh v otdalennom posleoperatsionnom periode pri razlichnykh variantakh saniruiushchei khirurgii.

The paper presents a comparative analysis of surgical outcomes in chronic maxillary ethmoiditis for radical and endonasal endoscopic operations in 85 patients. Objective control was performed with morphological, endoscopic and functional methods.

Time correlation between initial activation of ventricular myocardium and cardiac electric potentials on body surface in dogs.

Parameters of cardioelectric field on body surface and propagation of excitation in ventricular myocardium during initial activation were studied using multichannel synchronous electrocardiotopography. It was shown that inversion of areas of negative and positive potentials of cardioelectric field on body surface at the moment of excitation propagation to the epicardium reflected changes in the main direction of excitation wavefront in ventricles.

[Clinical and morphological analysis of adenoid vegetations in children]. / Kliniko-morfologicheskii analiz adenoidnykh vegetatsii u detei.

The paper outlines the authors' clinical and morphological experience in clinically rehabilitating children with adenoid vegetations and sinusitis. Retrospective morphological and immunohistological studies have revealed that the structure of adenoids corresponds to the morphology of humoral and cellular immune responses. This enables adenoid vegetations to be regarded as an actively functioning secondary immunity organ that requires maximum sparing in young children.

[Clinical and morphological aspects of benign tumor-like growths in the vocal cords]. / Kliniko-morfologicheskaia kharakteristika dobrokachestvennykh opukholepodobnykh obrazovanii golosovykh skladok.

The structure of the nasal septum was studied on 34 samples obtained from dead bodies of children aged 3 to 14. The septums were removed from the skull cavity. The morphometric studies consisted of measurements of the anteroposerior, superior-inferior, septum and its area, as well as composite anatomical structures. It is shown that the size and area of the septum and its anatomical structures undergo age-specific changes which are not regular. The data should be accounted for in correction of nasal septum structural defects in children of different age.

[Clinical and morphological characteristics of verrucous carcinoma]. / Kliniko-morphologicheskie osobennosti verrukoznoi kartsinomy.

Verrucose carcinoma is well differentiated squamous carcinoma characterized by exophitic growth, slow surface spread, marked lymphoplasmocytic infiltration and fibrosis of submucosal lining. Verrucose carcinoma runs relatively benign course, is effectively treated surgically, is prognostically favourable. There are cases free of both metastases and recurrences for postdiagnosis 15 years.

[Antibiotic therapy in children with pertussis]. / Antibiotikoterapiia pri kokliushe u detei.

The data accumulated within the last years required revision of the indications to the use of antibiotics in treatment of pertussis. One of the aims of antibiotic therapy in pertussis was to prevent colonization of B. pertussis in the respiratory tracts. With that end in view the choice of antibiotics should be limited by those, to which the pathogen is the most sensitive i.e. erythromycin, ampicillin and augmentin. Comparative efficacy of erythromycin and ampicillin during the first 2 weeks of the disease was studied in 79 infants at the age not older than 1 year with pertussis and it was shown that erythromycin was advantageous by its therapeutic activity and less side effects. Expedience of the antibiotic therapy during the spastic period for providing a preventive effect on development of bronchopulmonary complications was studied in 201 patients with pertussis. No preventive effect of the antibiotics on development of the bronchopulmonary complications defined by the secondary bacterial flora was recorded. In the group of the patients treated with the antibiotics prophylactically (group 1) the complications were 2.6 times more frequent than in the patients treated with pathogenetic agents alone (group 2). Intrahospital pneumonia developed in 8.9 per cent of the patients in group 1 and in 1.5 per cent of the patients in group 2. Therefore, antibiotics should not be used at the late periods of pertussis for prophylaxis of secondary bacterial complications.

[A case of tubercular laryngopharyngitis diagnosed by biopsy]. / Nabliudenie tuberkuleznogo laringofaringita, diagnostirovannogo po biopsii.

A 47-year-old man had ulcero-necrotic pharyngitis examined and treated without effect in various Moscow hospitals for 3 months. The diagnosis was established after histologic and bacteriologic examination of the biopsy.

[Characteristics of postoperative healing in patients with stenoses of the hollow organs of the neck (clinico-morphologic study)]. / Osobennosti posleoperatsionnogo zazhivleniia u bol'nykh so stenozami polykh organov shei (kliniko-morfologicheskoe issledovanie).

In 160 patients, postoperative healing of stenoses of hollow neck organs of various etiology was examined clinically and morphologically. All the patients were divided into 4 groups in terms of the etiological factor as follows: Group 1 (60 patients)--patients with post-traumatic stenoses of the larynx and trachea; Group 2 (34 patients)--patients with post-resuscitation stenoses of the larynx and trachea; Group 3 (38 patients)--patients with bilateral laryngoparalysis that developed after strumectomy; Group 4 (28 patients)--patients with postburn deformation of the pharyngolarynx and esophagus. Pathomorphological changes typical of a chronic inflammatory process were detected in the frontal neck tissues (skin, muscles, cartilages, mucous membrane) of all the patients. Morphologically, the frontal neck tissues were similar in all the patients. In view of this, a large number of suppurative-necrotic complications seen after surgery of stenoses of hollow neck organs (up to 45%) can be attributed to pathological lesions in the frontal neck tissues.