ABSTRACT
Blood rheology was assessed in 23 infants with acute pneumonia complicated with respiratory infectious toxicosis during hospitalization to intensive care wards, a control group consisted of 19 healthy infants. Plasma viscosity, red cell deformability, surface architectonics, and aggregation were studied. Patients developed increased plasma viscosity, marked reduction of red cell deformability, and increased aggregation index parallelled by reduced rate of aggregate formation. Changed red cell surface architectonics was associated with a reduced count of discocytes and parallel increase of echinocytes and cupola-like red cell forms. These data evidence marked disorders of blood rheology which should be not disregarded when choosing therapeutic policy.
Subject(s)
Pneumonia/blood , Toxemia/blood , Humans , Infant , Infant, Newborn , Pneumonia/complications , Rheology , Toxemia/etiologyABSTRACT
A study was made of the rheological blood properties, microcirculation, central and cerebral hemodynamics in children of the first year of life with complicated pneumonia. On admission to the department of intensive care and resuscitation the patients demonstrated pronounced hemorheological and hemodynamic disorders which might in many respects determine the disease gravity. Based on an analysis of the clinical observations and hemodynamic findings 3 periods of complicated pneumonia were distinguished in such children: the critical period, stabilization and repair. Each period is characterized by different compensatory adaptive and non-adaptive erythrocytic and hemodynamic reactions.
Subject(s)
Cardiac Output, Low/etiology , Cerebrovascular Circulation/physiology , Cerebrovascular Disorders/etiology , Erythrocyte Deformability/physiology , Hemodynamics/physiology , Pneumonia/physiopathology , Acute Disease , Cardiac Output, Low/diagnosis , Cerebrovascular Disorders/diagnosis , Humans , Infant , Microcirculation/physiopathology , Pneumonia/blood , Pneumonia/complicationsABSTRACT
The authors observed signs of premature maturation and activation of the hypophysio-adrenocortical system at the early postnatal period (the 70--90th hour) in the progeny of rats adrenalectomized 1 to 3 and 7 to 9 days before labour. A more pronounced in comparison with control (progeny of the sham-adrenalcetomized and intact rats) response to stress pointed to the early maturation of the suprahypophysial control mechanisms as well. Signs of functional exhaustion in the hypophysio-adrenocortical system and also in the thyroid gland were revealed in mature (6--10-month-old) rats born of adrenalectomized rats.
