ABSTRACT
The effect of i. v. administered nicotinic acid was examined in 23 patients. Before the patients had undergone an AFB-operation. 11 cardiovascular parameters were quantitatively examined, calculated and statistically controlled. The authors observed a short but clear decrease of pressure and resistance in the arterial system after the injections of nicotinic acid. The aim of increasing the blood supply to poststenotic regions can however not be attained in this way. The decrease can rather lead to a lack of the blood supply of these regions. The authors could verify that the vascular effect of nicotinic acid is not caused by adrenergic blockade. We are of the same opinion as other authors who maintain that nicotinic acid could be used in the therapy of the "shock lung". It is said that nicotinic acid as a fibrinolytic substance might counteract the Disseminated Intravascular Coagulation and that it could counteract the danger of oedema in the pulmonary system by decreasing pressure and resistance for a short time.
Subject(s)
Anesthesia, Epidural , Hemodynamics/drug effects , Nicotinic Acids/pharmacology , Adult , Aorta/surgery , Blood Pressure/drug effects , Capillaries/physiology , Cardiac Output/drug effects , Central Venous Pressure/drug effects , Femoral Artery/surgery , Heart Rate/drug effects , Humans , Meperidine/pharmacology , Middle Aged , Pulmonary Artery/physiology , Stroke Volume/drug effects , Vascular Resistance/drug effectsABSTRACT
The authors could verify the heart rate increasing effect of atropine. The different sympathetic and parasympathetic activity caused by the method of operation and the kind of anaesthesia had a modifying effect on the heart frequency increase. In contrast to a small heart rate increase in halothaneanaesthesia, the increase in epidural- and neuroleptanaesthesia was higher. In addition medical treatment with pancuronium modified the effect of atropine. The frequency increase in patients who had got pancuronium was significantly smaller - the basic rate being higher - than in patients who hadn't got pancuronium. Those patients reacted vice versa. The authors found out that by giving 1 mg of atropine a maximum effect could be expected and that there couldnt be spoken of an overdosage.
