ABSTRACT
To evaluate cellular immunity in children with uveitis, we used the flow cytometry method to study the T lymphocyte subpopulation in peripheral blood. Cytometric analysis of peripheral blood lymphocytes using fluorochrome-marked monoclonal antibodies was carried out in 29 children aged 6-18 years with parasitic uveitis (group A) and with uveitis of another etiology (group B). The control group consisted of 28 healthy children aged 6-15 years. A substantially higher percentage of B lymphocytes (19.0 +/- 6.03) was observed in the children with parasitic uveitis than was observed in the healthy children. Moreover, the absolute values were higher in groups A (1.60 +/- 0.53) and B (1.81 +/- 0.40) than in controls (1.50 +/- 0.38). The lowest percentage of CD4+ lymphocytes (34.25 +/- 6.06) and the highest percentage of CD8+ lymphocytes (31.14 +/- 6.50) was found in children with parasitic uveitis. The lowest index CD4+/CD8+ (1.29 +/- 0.53) in the group of children with parasitic uveitis reflected severe disorders in response regulation. However, the percentage values of natural killer cells was lower in the two groups of patients than in controls. These results suggest that quantitative changes in the subpopulation of peripheral blood lymphocytes are more pronounced in parasitic uveitis.
Subject(s)
B-Lymphocytes/immunology , T-Lymphocyte Subsets/immunology , Uveitis/immunology , Adolescent , Child , Female , Humans , Immunity, Cellular , Lymphocyte Count , MaleABSTRACT
Evaluation of lymphocyte in children with uveitis basing on the study of T lymphocyte subpopulation in the peripheral blood using the flow cytometry method is presented. Cytometric analysis of peripheral blood lymphocytes using fluorochrome-marked monoclonal antibodies was carried out in 29 children, aged 6-18, with parasitic uveitis (group A) and with uveitis of another aetiology (group B). Control group consisted of 28 healthy children aged 6-15. The absolute values of T lymphocytes were higher in groups A (x = 1.60 +/- 0.53) and B (x = 1.81 +/- 0.40) compared to controls (x = 1.50 +/- 0.38). The lowest percentage of CD4+ lymphocytes (x = 34.25 +/- 6.06) and the highest percentage of CD8+ lymphocytes (x = 31.14 +/- 6.50) were revealed in children with parasitic uveitis. The lowest index CD4+/CD8+ (x = 1.29 +/- 0.53) in the group of children with parasitic uveitis reflects severe disorders in response regulation. However, the percentage values of NK cells were lower in the two groups of patients compared to controls. The results allow for the assumption that quantitative changes in the subpopulation of peripheral blood lymphocytes are more pronounced in parasitic uveitis.
Subject(s)
CD4-Positive T-Lymphocytes/immunology , CD8-Positive T-Lymphocytes/immunology , Eye Infections, Parasitic/immunology , Uveitis/immunology , Adolescent , Adult , Antibodies, Monoclonal , CD4-CD8 Ratio , Child , Female , Flow Cytometry , Humans , Lymphocyte Activation , MaleABSTRACT
Craniopharyngiomas are slow-growing tumours arising from vestigal remnants of Rathke's pouch along the pituitary stalk. A case of 9-year old child with craniopharyngioma is presented. Immediate diagnostic and surgical treatment improved clinical condition.
Subject(s)
Craniopharyngioma/diagnosis , Child , Craniopharyngioma/surgery , Female , Humans , Neoplasm Invasiveness , Tomography, X-Ray ComputedABSTRACT
The case of morning glory syndrome in two years old patient is presented.
Subject(s)
Optic Nerve Diseases/diagnostic imaging , Child, Preschool , Female , Fundus Oculi , Humans , Syndrome , Ultrasonography , Visual Acuity/physiologyABSTRACT
MATERIAL: A case of a 14-year-old boy with recurrent idiopathic bilateral uveitis. METHODS: Detection of Helicobacter pylori infection basing on endoscopic examination of upper alimentary tract and eradication of this factor using specific therapy leading to extinction of active uveitis in both eyes. RESULTS: Helicobacter pylori may be the etiological agent of uveitis in children with unknown reason of the disease.
Subject(s)
Helicobacter Infections/complications , Helicobacter pylori/isolation & purification , Uveitis/microbiology , Adolescent , Gastroscopy/methods , Humans , Male , Recurrence , Uveitis/therapyABSTRACT
UNLABELLED: The aim of our study was to evaluate the results of the operation on squint with pathological attachment of lateral rectus revealed during surgery. MATERIAL AND METHODS: The study involved 22 children (12 girls and 10 boys) out of 320 children operated on for squint in the years 1993-1996, who had pathological attachment of lateral rectus. Alternating convergent squint was found in 12 children, unilateral in 10. Muscle exposure showed dislocation of lateral rectus attachment--upwards by c. 1.5 mm in 11 children, downwards and obliquely by c. 2 mm in 10 children, in 1 child the upper part of the attachment was shifted forward by 1 mm. During the surgery, in addition to the reduction of squint angle, physiological attachment of the rectus was reconstructed. RESULTS: The operation restored parallel position of the eyes in 22 children, very good vision was obtained in 12 (54%) with alternating convergent squint, significant improvement in 5 (22%) with unilateral convergent squint, and only slight improvement in the remaining 5 (22.7%) with high initial amblyopia and squint angle from +15 degrees to +30 degrees.
Subject(s)
Oculomotor Muscles/abnormalities , Oculomotor Muscles/surgery , Strabismus/surgery , Child , Child, Preschool , Female , Humans , Male , Retrospective Studies , Severity of Illness Index , Strabismus/diagnosis , Treatment OutcomeABSTRACT
Open anterior fontanel cerebral ultrasonography was performed in 113 children aged between 1 month and 2 years, infants with purulent meningitis and encephalitis. It revealed early CNS complications in 50 patients (44.2%). The treatment protocol was adjusted for different types of complications. All children were discharged home and referred for further care to paediatricians and neurologists. Transfontanel ultrasonography is of great value for evaluating different types of complications following CNS infections.
Subject(s)
Brain/physiopathology , Encephalitis/physiopathology , Meningitis, Bacterial/physiopathology , Candida albicans/isolation & purification , Child, Preschool , Echoencephalography , Encephalitis/microbiology , Enterobacter/isolation & purification , Female , Humans , Infant , Male , Meningitis, Bacterial/microbiology , Streptococcus/isolation & purificationABSTRACT
The authors described symptoms of Rubinstein-Taybi syndrome and presented a treatment of this disease. It concerned a 1-year-old baby with obstruction of left lacrimal ducts, psychomotor retardation and facial abnormalities.
Subject(s)
Rubinstein-Taybi Syndrome/diagnosis , Humans , Infant , Male , Rubinstein-Taybi Syndrome/therapyABSTRACT
PURPOSE: The aim of the study was evaluation of the rate of posterior capsule opacification after extracapsular cataract extraction with and without implantation of intraocular lens. MATERIAL AND METHOD: The clinical material comprised 77 patients operated on in the years 1990-1994. Only the cases in which visual acuity exceeded 5/10 were included into the study. 107 eyes were examined, among them 75 after implantation of posterior chamber intraocular lens. RESULTS: Opacification of the posterior capsule occurred in 37 eyes, but only in 25 of 75 eyes in the patients with implantation of the artificial lens. We found that following extracapsular cataract extraction without implantation of intraocular lens, opacification of the posterior capsule occurs more frequently, especially during 1-2 years after the surgery. CONCLUSION: Cortical-nuclear cataract and not much advanced age are factors predisposing for greater rate of opacification of the posterior capsule after extracapsular cataract extraction.
