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1.
Circulation ; 116(7): 714-20, 2007 Aug 14.
Article in English | MEDLINE | ID: mdl-17679619

ABSTRACT

BACKGROUND: Short-QT syndrome is an inherited disorder characterized by a short QT interval and an increased risk of sudden cardiac death. The clinical significance of a short QT interval observed in a randomly recorded ECG is not known. Therefore, we assessed the prevalence and prognostic significance of a short QT interval in a general population. METHODS AND RESULTS: QT intervals were measured from the 12-lead ECGs of 10 822 randomly selected middle-aged subjects (5658 males, mean age 44+/-8.4 years) enrolled in a population study and followed up for 29+/-10 years. The end points were all-cause and cardiovascular mortality. In addition to Bazett's method (corrected QT interval, or QTc), the Fridericia (QTfc) and nomogram (QTnc) methods were used to correct the QT interval for heart rate. The cutoff values for short QT intervals were defined as 320 ms (very short) and 340 ms (short). The prevalence of QT interval <320 ms based on QTc, QTfc, and QTnc was 0.10%, 0.08%, and 0.06%, and the prevalence of QT interval <340 ms was 0.4%, 0.3%, and 0.3%, respectively. The majority of subjects with short QT intervals were males. All-cause or cardiovascular mortality did not differ between subjects with a very short or short QT interval and those with normal QT intervals (360 to 450 ms). There were no sudden cardiac deaths, aborted sudden cardiac deaths, or documented ventricular tachyarrhythmias among subjects with a QTfc <340 ms. CONCLUSIONS: A short QT interval does not appear to indicate an increased risk for all-cause or cardiovascular mortality in middle-aged nonreferral, community-based individuals.


Subject(s)
Arrhythmias, Cardiac/epidemiology , Arrhythmias, Cardiac/mortality , Adult , Arrhythmias, Cardiac/diagnosis , Electrocardiography , Female , Finland/epidemiology , Follow-Up Studies , Humans , Male , Middle Aged , Prevalence , Prognosis , Syndrome
5.
Ann Chir Gynaecol ; 83(4): 292-5, 1994.
Article in English | MEDLINE | ID: mdl-7733612

ABSTRACT

Eighty-six patients who had undergone aortic valve surgery were reviewed. Forty-three had received crystalloid cardioplegia, the other 43 blood cardioplegia. Spontaneous beating after cross-clamp release (blood 11; crystalloid 0; P < 0.001), number of defibrillations (blood 2.1 +/- 2.6; crystalloid 3.8 +/- 2.2; P < 0.01) and CK-MB values on the operation day (blood 65 +/- 55, crystalloid 112 +/- 73; P < 0.001) and on the following day (blood 53 +/- 43, crystalloid 96 +/- 98; P < 0.01) indicated that blood is a better cardioplegic vehicle for patients with hypertrophied hearts.


Subject(s)
Aortic Valve Insufficiency/surgery , Aortic Valve Stenosis/surgery , Blood , Cardioplegic Solutions , Heart Arrest, Induced/methods , Heart Valve Prosthesis , Adult , Aged , Aortic Valve/surgery , Aortic Valve Insufficiency/mortality , Aortic Valve Stenosis/mortality , Cause of Death , Female , Humans , Male , Middle Aged , Myocardial Infarction/etiology , Myocardial Infarction/mortality , Myocardial Reperfusion Injury/etiology , Myocardial Reperfusion Injury/mortality , Postoperative Complications/etiology , Postoperative Complications/mortality , Retrospective Studies , Risk Factors
9.
Biochem J ; 185(1): 189-94, 1980 Jan 01.
Article in English | MEDLINE | ID: mdl-7378046

ABSTRACT

Measles virus was propagated in VERO cells and purified from the culture supernatants by two successive tartrate-density-gradient centrifugations. Surface carbohydrates were labelled both in vitro and in vivo with 3H after treatment with galactose oxidase/NaB3H4 or with [3H]glucosamine. The major labelled glycoprotein in measles virions had a mol.wt. of 79 000. After labelling with periodate/NaB3H4, which would result in specific labelling of sialic acid residues, the 79 000-mol.wt. glycoprotein was very weakly labelled. This suggests that there is no or a very low amount of sialic acid in the virions. Further analysis of the glycoprotein showed that galactose is the terminal carbohydrate unit in the oligosaccharide, and the molecular weight of the glycopeptide obtained after Pronase digestion is about 3000. The oligosaccharide is attached to the polypeptide through an alkali-stable bond, indicating a N-glycosidic asparagine linkage.


Subject(s)
Glycopeptides/analysis , Glycoproteins , Measles virus/analysis , Chromatography, Paper , Electrophoresis, Polyacrylamide Gel , Oligosaccharides/analysis
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