ABSTRACT
O presente artigo analisou alterações na percepção corporal e medo do reganho de peso em10 pacientes submetidos à cirurgia bariátrica de Fobi-Capella (Bypass Gástrico em Y de Roux)há no mínimo quatro anos, que tiveram reganho de pelo menos 20% do peso perdido. Foi utili-zado um roteiro de entrevista semiestruturada sobre: dados demográficos, hábitos alimenta-res, mudanças no estilo de vida e comportamentais, imagem corporal, preconceitosvivenciados e reaquisição de peso. As entrevistas foram gravadas, transcritas e submetidas àanálise de conteúdo. Observou-se que o reganho de peso ocorreu de modo desapercebido pe-lo paciente, até que tenha sido sinalizado socialmente; o emagrecimento excessivo foi malavaliado pelos pares; observou-se medo acentuado, por parte dos operados bariátricos, devoltar à obesidade mórbida; os participantes relataram alterações nas relações afetivas; a per-cepção da imagem corporal oscilou e era infiel à aparência externa(AU)
Subject(s)
Bariatric Surgery/psychology , Body Image/psychologyABSTRACT
INTRODUCTION: Sotrastaurin is an immunosuppressant that blocks T-lymphocyte activation via protein kinase C inhibition. The authors determined whether a pharmacokinetic interaction occurs between sotrastaurin and everolimus, both of which are substrates and inhibitors of CYP3A4. METHODS: This was a randomized, three-period, crossover study in 18 healthy subjects. They received single oral doses of (1) 100 mg sotrastaurin, (2) 2 mg everolimus, and (3) the drug combination. Clinical and pharmacokinetic data were collected to Day 5 after each treatment. RESULTS: Coadministration of everolimus decreased sotrastaurin C(max) from 638 +/- 295 to 539 +/- 211 ng/ml yielding a combination/ monotherapy ratio (90% confidence interval) of 0.87 (0.76 - 1.00). Sotrastaurin total AUC was not altered by everolimus with values of 3660 +/- 1853 versus 3630 +/- 2006 ng*h/ml and a ratio of 1.00 (0.88 - 1.13). Sotrastaurin increased everolimus C(max) from 15 +/- 6 to 16 +/- 6 ng/ml yielding a ratio of 1.15 (0.99 - 1.33) and increased everolimus total AUC from 114 +/- 50 to 137 +/- 56 ng*h/ml yielding a ratio of 1.20 (1.05 - 1.37). The possibility that a higher dose of sotrastaurin than used in this study might further increase everolimus blood levels cannot be excluded. CONCLUSIONS: Coadministration of a single 100 mg dose sotrastaurin with a single 2 mg dose everolimus did not alter sotrastaurin pharmacokinetics to a clinically relevant extent. Everolimus AUC was increased 20% by sotrastaurin.
Subject(s)
Immunosuppressive Agents/pharmacokinetics , Protein Kinase Inhibitors/pharmacology , Pyrroles/pharmacology , Quinazolines/pharmacology , Sirolimus/analogs & derivatives , Administration, Oral , Adult , Area Under Curve , Cross-Over Studies , Cytochrome P-450 CYP3A/metabolism , Drug Interactions , Everolimus , Humans , Male , Protein Kinase C/antagonists & inhibitors , Sirolimus/pharmacokinetics , Young AdultABSTRACT
In the 21 years since the description of the antiphospholipid syndrome (APS), neurological features have become recognised as some of the most important and common aspects of the syndrome. Recognition of the relationship between APS and central nervous system impairment could open the door to improved treatment and outcomes in some neurological syndromes.
Subject(s)
Antiphospholipid Syndrome/complications , Antiphospholipid Syndrome/immunology , Nervous System Diseases/etiology , Nervous System Diseases/immunology , Antiphospholipid Syndrome/physiopathology , Humans , Nervous System Diseases/physiopathology , Thrombosis/etiology , Thrombosis/immunology , Thrombosis/physiopathologyABSTRACT
The application of multivariate curve resolution-alternating least squares (MCR-ALS) to the quantitative analysis of different metal ion mixtures using voltammetric data is described. The performance of MCR-ALS was evaluated in the resolution and quantitation of overlapped voltammetric peaks obtained in the analysis of binary and quaternary mixtures of Cd(II), In(III), Pb(II) and Tl(I) metal ions by anodic stripping voltammetry. Quality assessment of qualitative and quantitative determinations was evaluated considering the effects of different constraints and of initial estimations. MCR-ALS results were validated and compared with those obtained by applying other well-established multivariate calibration methods, such as partial least squares (PLS) and direct classical least squares (DCLS) methods.
ABSTRACT
OBJECTIVES: To describe sexual risk for HIV infection among adult night school students in São Paulo, Brazil, and to evaluate the effect of an HIV/AIDS prevention workshop to reduce sexual risk. SUBJECTS AND METHODS: A longitudinal study was conducted among four demographically similar public night schools in the inner city of São Paulo. Schools were randomized into intervention and control conditions. Of 394 young adults who took part in the baseline survey, 304 (77%) completed a postintervention questionnaire. INTERVENTIONS: In a workshop consisting of four sessions of 3 h each, the students discussed AIDS symbolism, the impact of AIDS on their lives, risk perception, the way in which sexual norms shape knowledge and attitudes, AIDS-related knowledge, reproduction and sexual pleasure, and condom use negotiation. We fostered community-building through AIDS training courses for teachers in the schools, peer support programs and public events. RESULTS: At baseline, 87% had been sexually active at some time and 76% had had sex in the past 6 months. Among those who reported vaginal intercourse and/or anal intercourse, condom use was low. The workshops were positively process-evaluated and supported by the community, the students, their teachers and their parents. We obtained statistically significant effects from the workshops for females only, who reported improved communication with partners about sex and AIDS and less unprotected sex with non-monogamous partners after the intervention. CONCLUSION: These data show that the sexual risk of HIV infection can be lowered when Brazilian disenfranchized communities support AIDS prevention workshops. Even more impressive results may be achieved if the need to address socioeconomic obstacles and gendered sexual roles is emphasized through further long-term community development programs.
Subject(s)
Acquired Immunodeficiency Syndrome/prevention & control , Health Education , Sexual Behavior , Acquired Immunodeficiency Syndrome/epidemiology , Adolescent , Adult , Brazil/epidemiology , Female , Humans , Male , SchoolsABSTRACT
Os autores apresentam um estudo experimental realizado com ratos Wistar, com intuito de comparar a ocorrência de aderências peritoneais após estimulaçao por quatro tipos de lesoes da parede abdominal em sua face peritoneal. Vinte animais machos foram utilizados após laparatomia mediana de aproximadamente 6 cm de extensao e incluídos em um dos quatro grupos a seguir; Grupo A - áreas isquêmicas; Grupo B - áreas isquêmicas cruentas; Grupo C - áreas cruentas; Grupo D - áreas cruentas cauterizadas por bisturi elétrico. Observou-se que o Grupo C mostrou diferença estatisticamente significante em relaçao aos outros grupos (A, B e D), mostrando um menor índice de aderências.
