ABSTRACT
Experimental models of stomatitis developing in response to an isolated (radiation) and combined (radiation and chemical) exposure of experimental animals, were created. The severity of radiation-induced stomatitis was determined by the dose of radiation exposure. Additional exposure to a chemical factor (cyclophosphamide) augmented the destructive effect of ionizing radiation on the buccal mucosa of rats.
Subject(s)
Antineoplastic Agents, Alkylating/toxicity , Cyclophosphamide/toxicity , Mouth Mucosa/radiation effects , Radiation Injuries, Experimental/physiopathology , Stomatitis/physiopathology , Animals , Animals, Outbred Strains , Appetite/drug effects , Appetite/radiation effects , Chemoradiotherapy/adverse effects , Disease Models, Animal , Motor Activity/drug effects , Motor Activity/radiation effects , Mouth Mucosa/drug effects , Mouth Mucosa/pathology , Radiation Injuries, Experimental/etiology , Radiation Injuries, Experimental/pathology , Rats , Stomatitis/etiology , Stomatitis/pathologyABSTRACT
Experimental studies on white outbred male mice subjected to gamma-irradiation at doses LD(80/30) have found that the therapeutic use of Litan contributes to the increase (by 40-50%) in the survival rate of the animals. Introduction to irradiated animals of Litan increases the intensity of the inclusion of 3H-thymidine in the DNA of the bone marrow cells and is associated with a growing number of splenic endogenous colonies, which can testify to the stimulating influence of the drug on the proliferation and differentiation of hematopoietic cells, as well as on the deficit restoration of full-fledged mature cell forms in the peripheral blood.
