ABSTRACT
We compute the purely gluonic contribution to the static QCD potential at three-loop order. This completes computation of the static potential at this order.
ABSTRACT
Measles is frequently complicated with pneumonia that could be fatal in numerous occasions. However, a prompt and precise diagnosis of measles is not easily made particularly in the early stage of the disease, or in immunocompromised individuals because of the lack of typical clinical features or the defect in antigen-specific antibody production. In the present paper, we describe a 27-yr-old male who developed fever, skin rash typical of measles, and diffuse pulmonary infiltrates associated with respiratory failure. Infection of lung cells with measles virus was proved by detection of viral genome ribonucleic acid within alveolar macrophages and lymphocytes recovered by bronchoalveolar lavage using reverse transcription-polymerase chain reaction amplification. These techniques may offer a useful tool to make the swift and precise diagnosis of measles pneumonia, thus allowing appropriate therapeutic approaches to the disease.
Subject(s)
Bronchoalveolar Lavage Fluid/cytology , Genome, Viral , Measles virus/genetics , Pneumonia, Viral/virology , Adult , Humans , MaleABSTRACT
A 50-year-old woman was admitted to our hospital because of dyspnea on exertion. A chest X-ray film showed cardiomegaly and echocardiography revealed right-heart overload. Right heart catheterization studies revealed pulmonary hypertension and no signs of pulmonary embolism or vasculitis. The patient had complained of Raynaud's phenomenon since 6 years before admission. She did not notice eye or mouth dryness, but examination of a lip-biopsy specimen showed infiltration of lymphocytes into the salivary glands. Laboratory findings showed hypergammaglobulinemia and hemolytic anemia. Primary Sjögren's syndrome with pulmonary hypertension was diagnosed. Her general condition improved with steroid pulse therapy followed by oral administration of corticosteroids and cyclophosphamide.
Subject(s)
Hypertension, Pulmonary/etiology , Sjogren's Syndrome/complications , Anemia, Hemolytic/complications , Anti-Inflammatory Agents/administration & dosage , Cyclophosphamide/administration & dosage , Female , Humans , Hypergammaglobulinemia/complications , Hypertension, Pulmonary/drug therapy , Immunosuppressive Agents/administration & dosage , Methylprednisolone/administration & dosage , Middle Aged , Prednisolone/administration & dosage , Raynaud Disease/complications , Sjogren's Syndrome/drug therapySubject(s)
Cystic Fibrosis , 1-Methyl-3-isobutylxanthine/therapeutic use , Adenosine Triphosphate/therapeutic use , Amiloride/therapeutic use , Aminoglycosides , Anti-Bacterial Agents/therapeutic use , Cystic Fibrosis/etiology , Cystic Fibrosis/therapy , Cystic Fibrosis Transmembrane Conductance Regulator/genetics , Diagnosis, Differential , Diuretics/therapeutic use , Humans , Mutation , Phosphodiesterase Inhibitors/therapeutic use , PrognosisABSTRACT
Cystic fibrosis (CF), the most common fatal hereditary disorder in Caucasians, is caused by mutations of the CF transmembrane conductance regulator (CFTR) gene. The protein product encoded by the CFTR gene is a cyclic-AMP-regulated Cl- channel that is dependent on protein kinase phosphorylation and requires binding of ATP for channel opening, but may have additional functions. Although the most common mutation of the CFTR gene (DeltaF508) is found in approximately 70% of CF chromosomes, more than 400 other mutations of the gene have been documented. Several new therapeutic approaches including gene therapy by transfer of the normal CFTR gene to airway epithelium and protein replacement by reconstituting a recombinant functional CFTR protein into the membrane lipid bilayer are being extensively pursued.
Subject(s)
Cystic Fibrosis , Chloride Channels , Cyclic AMP , Cystic Fibrosis Transmembrane Conductance Regulator/genetics , Cystic Fibrosis Transmembrane Conductance Regulator/physiology , Genetic Therapy , Humans , MutationABSTRACT
A method of storing and analyzing Goldmann's visual fields with a personal computer has been developed and applied to cases of retinal detachment. Original two-dimensional analogue data, obtained manually by ophthalmologists, were digitized and transferred to a personal computer. A one-megabyte floppy disk was able to store data of 170 charts. Stored data were easily displayed on the CRT of the computer using two- and three-dimensional graphics. Total and four quadrant areas surrounded by isopter curves were calculated for fellow eyes, diseased eyes and operated eyes. Furthermore, weighted areas with four types of weighting function which attach more importance to the center than the periphery of a visual field were calculated. Power type weighting function was found to give the most significant effect on emphasizing abnormality of eyes with retinal detachment.
Subject(s)
Retinal Detachment/physiopathology , Visual Fields , Adult , Aged , Humans , Microcomputers , Middle AgedSubject(s)
Fracture Fixation/nursing , Humans , Manuals as Topic , Postoperative Care , Preoperative CareSubject(s)
Cataract Extraction/nursing , Humans , Manuals as Topic , Postoperative Care , Preoperative CareSubject(s)
Dental Caries/genetics , Streptococcus mutans/pathogenicity , Animals , Female , Male , Mice , Mice, Inbred Strains , Sex FactorsABSTRACT
Glutamine has been shown to be a preferred energy source for some established cell lines and cancer cells in culture (Kovacevic, 1971; Kovacevic, 1972; Lavietes, 1974). Empirically, glutamine is the most abundant amino acid in most of the culture media developed. The major end product of glutamine metabolism is ammonia. Ammonia build up is one of the limiting factors in the proliferation of mammalian cells in higher density culture and is directly related to the initial glutamine concentration. The susceptibility of glutamine to thermodecomposition prevents the heat sterilization of glutamine-enriched media and this significantly increases the cost of medium preparation at the industrial scale. In an attempt to overcome these drawbacks, a population of Namalva cells capable of growing in glutamine-free media was established. The adapted cells were found to contain a higher level of glutamine synthetase activity which enable them to synthesize sufficient amounts of glutamine for their growth.