ABSTRACT
INTRODUCTION: Leser-Trelat sign is a paraneoplastic marker characerized by the abrupt appearance of seborrheic keratoses. It is described in association with many underlying malignant diseases. CASE REPORT: We report a case of coexistence of two rare entities, represented by the Leser-Trelat sign occurring with male breast cancer. DISCUSSION: The asscociation of male breast cancer and LT sign is decidedly unusual. To our knowledge, our case report is the second to describe the association of these two rare entities. CONCLUSION: A proper dermatological examination and a good knowledge of cutaneous paraneoplastic syndromes can be of great help in screening for multiple skin cancers.
ABSTRACT
INTRODUCTION AND IMPORTANCE: Condyloma are a common and easily diagnosticated condition that could affect the area around and inside the anus. But a nodular perianal lesion is not always a simple condyloma. CASE PRESENTATION: We report a case of a 61-year-old patient with nodular perianal lesions mimicking condyloma that has revealed an amylosis and a multiple myeloma. CLINICAL DISCUSSION: The cutaneous manifestations of amyloidosis are diverse. Perianal nodular lesions were indicative of cutaneous amyloidosis in our patient. It is imperative to screen systemic involvement for amyloidosis. CONCLUSION: Our case report highlights the importance of minitious physical examination because some simple lesions can hide dangerous affections.
ABSTRACT
INTRODUCTION: Several cutaneous manifestations have been described during COVID-19 infection, however ungual signs remain neglected. Half and half nail or Lindsay nails is a rare clinical finding, frequently seen in chronic renal failure, and many other disorders. CASE REPORT: We report 2 cases of half and half nail aspect occurring during severe COVID-19 infection, without a history of kidney disease, suggesting that 'Lindsay Nails' can be considered as a severity marker. DISCUSSION: An increasing number of nails changes has been reported since the COVID-19 outbreak. As well as the acral manifestations of COVID-19, the acute appearance of Half and half nail sign can be explained by a vascular involvement that may induce a transient matrix injury. CONCLUSION: We report the first description of acute onset of half and half nails during COVID-19 severe infection in 2 patients without a history of kidney failure or any other condition previously described, suggesting that it can be considered as a severity marker.
