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Can Vet J ; 45(10): 831-7, 2004 Oct.
Article in English | MEDLINE | ID: mdl-15532882

ABSTRACT

The purpose of this study was to identify oxidative damage to renal allografts during graft rejection by evaluating changes in oxidative markers and plasma lactate levels in feline renal allotransplant recipients. Heterotopic renal allotransplantations were performed between 8 adult feline cross-matched donors. Following 14 d of immunosuppression, the drugs were discontinued to allow allograft rejection. Baseline and serial postoperative evaluations of serum creatinine, plasma lactate, plasma thiobarbituate reactive substances (TBARS), plasma creatol, urine creatol, and renal sonographic cross-sectional area were performed. When sonographic evaluation revealed the absence of blood flow to the allograft, the rejected kidney was nephrectomized and evaluated histopathologically. Allograft rejection occurred in all cats by day 26. A significant elevation in body temperature occurred during the rejection period. No significant change was observed between any of the time periods for plasma TBARS, creatol, or urine creatol. There was a significant decrease in plasma lactate levels throughout the study. Markers of oxidative stress from venous blood did not reflect renal allograft rejection in cats with a normally functioning native kidney. Renal allograft rejection may be associated with significant increases in body temperature and warrants further investigation.


Subject(s)
Creatinine/analogs & derivatives , Creatinine/blood , Graft Rejection/veterinary , Kidney Transplantation/veterinary , Thiobarbituric Acid Reactive Substances , Animals , Biomarkers/blood , Cat Diseases/surgery , Cats , Creatinine/urine , Fever/veterinary , Graft Rejection/blood , Graft Rejection/diagnosis , Kidney/blood supply , Kidney/diagnostic imaging , Kidney Failure, Chronic/surgery , Kidney Failure, Chronic/veterinary , Kidney Function Tests/methods , Kidney Function Tests/veterinary , Lactic Acid/blood , Male , Oxidative Stress , Predictive Value of Tests , Specific Pathogen-Free Organisms , Ultrasonography
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