Jatobá-do-cerrado (Hymenaea stigonocarpa Mart.) pulp positively affects plasma and hepatic lipids and increases short-chain fatty acid production in hamsters fed a hypercholesterolemic diet.

This study aimed to assess the impact of jatobá pulp, in its fresh (FJ) and extruded (EJ) forms, on lipid metabolism and intestinal fermentation parameters in hamsters. In a 21-day experiment, we determined the parameters of the animal lipid metabolism and colonic production of short chain fatty acids in four different groups. Control (C), fresh pulp (FJ) and extruded pulp (EJ) were fed using hypercholesterolemic diets, and the reference (R) was fed using AIN93 meal. R and C diets contained cellulose, FJ and EJ were added by jatobá pulp as a fiber source. The results showed that FJ and EJ exhibited lower levels of triglycerides, total cholesterol, LDL-c, non-HDL-c serum levels, liver lipids, and liver weight compared to C. The EJ had higher bile acid excretion in stool than the C. EJ and FJ exhibited lower excreted fiber compared to R and C, implying greater fermentation. Furthermore, the production of short-chain fatty acids (SCFA) in the cecum of FJ and EJ animals exceeded that of the C. Acetic and propionic acids were more abundant in the FJ and EJ diets, with FJ producing more butyric acid than the other groups.In conclusion, jatobá pulp maintained at normal levels of total cholesterol, LDL and HDL-associated cholesterol, non-HDL cholesterol, and serum triglycerides, while also reducing the accumulation of hepatic lipids. Jatobá also promoted SCFA formation and fermentation, making it a valuable ingredient for preventing chronic diseases.

Coffee simulated inhibition of pancreatic lipase and antioxidant activities: Effect of milk and decaffeination.

Noncommunicable diseases (NCDs) are the leading cause of mortality worldwide. Dietary intake of polyphenols may protect against the development of NCDs. Coffee is a rich source of phenolic acids in the Western diet that may prevent or treat hyperlipidemia, type 2 diabetes, chronic liver diseases, and obesity. These health effects are attributed, at least partially, to the antioxidant properties and inhibitory activity of phenolic acids on lipases. However, the effect of milk on these properties is not clear. Thus, we aimed to evaluate the antiradical properties and inhibitory activity on pancreatic lipase in vitro of phenolic acids from coffee. We obtained commercial traditional and decaffeinated espresso coffee capsules and prepared the beverages according to the manufacturer's instructions using a domestic coffee maker. Espresso prepared with traditional and decaffeinated coffee capsules were evaluated with and without the addition of milk following in vitro digestion.The total phenolic content ranged from 168.21 to 397.38 mg equivalent to chlorogenic acid/mL. All coffee-based beverages showed antioxidant activity, with emphasis on decaffeinated and milk-added beverages, respectively. Caffeic acid was the most abundant phenolic compound followed by 5-caffeoylquinic acid before digestion. In contrast after in vitro digestion, only caffeic acid was bioaccessible. The addition of milk improved the bioaccessibility of caffeic acid and caffeine. Overall, the half-maximal inhibitory concentration of the samples for pancreatic lipase varied between 222 and 3035.8 µg/mL. Decaffeinated coffee had a greater inhibitory effect than regular coffee regardless of milk addition. In conclusion, decaffeinated and milk-added coffee beverages have a greater effect on lipase inhibition. This may be related to the greater bioaccessibility of phenolic compounds in these samples. Further studies are needed to elucidate the mechanisms of enzymatic inhibition by phenolic acids.