ABSTRACT
Com os avanços na Medicina Veterinária, houve um aumento na expectativa de vida dos animais de companhia, e em contrapartida,a incidência de doenças crônicas como o câncer tem aumentado nestes animais. O linfoma é uma neoplasia maligna de linfócitoscomumente encontrada nos caninos e sua incidência é progressiva, em torno de 24 a 33 casos por ano para cada 100.000 cães.Foram consultadas as fichas do Setor de Patologia Animal da Universidade Federal de Uberlândia (UFU), no período compreendidoentre janeiro de 2003 e dezembro de 2013, para avaliar a frequência de linfoma nos cães assistidos no Hospital Veterinário (UFU)neste período. Informações como o tipo de exame realizado, sexo, idade, raça e tipo de amostra foram coletadas. Também foiavaliada a frequência do linfoma entre os tumores de células redondas. Posteriormente, os dados foram comparados utilizandoseestatística descritiva e porcentual. De todos os 6403 registros, 70,3% dos diagnósticos de linfoma foram observados por meiode citologia e 29,6% por histopatologia. O linfoma foi o segundo tumor de células redondas mais frequente em 23,1%. Não houvepredileção sexual e os cães adultos e idosos representaram as faixas etárias mais afetadas. A raça Pit Bull foi a mais frequenteem 28,2% dos casos. Em 53,3% dos diagnósticos citológicos conclusivos sem necessidade de biópsia, os cães apresentaramlinfadenomegalia na avaliação clínica. A citologia pode ser uma boa ferramenta no diagnóstico de linfomas, auxiliado pela avaliaçãofísica dos linfonodos superficiais.(AU)
With advances in veterinary medicine, there was an increase in life expectancy of pets, and on the other hand, the incidence ofchronic diseases such as cancer has increased in these animals. Lymphoma is a malignant neoplasm of lymphocytes commonlyfound in canine and its incidence is progressive, around 24-33 cases per year for each 100.000 dogs. The reports of the Sectorof Animal Pathology, Federal University of Uberlândia (UFU), were consulted in the period between January 2003 and December2013 to assess the frequency of lymphoma in dogs assisted at the Veterinary Hospital (UFU) in this period. Information such asthe type of examination, gender, age, and type of sample was collected. We also evaluated the frequency of lymphoma betweenthe round cell tumors. Later, the data were compared using descriptive statistics and percentage. Of all 6403 records, 70.3% oflymphoma diagnoses were observed by cytology and 29.6% by histopathology. Lymphoma was the second most frequent roundcell tumor in 23.1%. There was no sexual predilection and the adult and elderly dogs represented the most affected age groups.The Pit Bull breed was the most frequent in 28.2% of the cases. In 53.3% of the conclusive cytologic diagnoses without biopsy, thedogs presented lymphadenomegaly in the clinical evaluation. Cytology can be a good tool in the diagnosis of lymphomas, aidedby the physical evaluation of superficial lymph nodes.(AU)
Subject(s)
Animals , Dogs , Dogs/abnormalities , Lymphoma/epidemiology , Lymphoma/veterinary , NeoplasmsABSTRACT
Background: The human epidermal growth factor type 2 (HER2) receptor is a membrane glycoprotein tyrosine kinase. In woman, HER2 expression is diagnosed in 30% of breast carcinomas and it is associated with a worse prognosis, higher rate of recurrence and mortality. In the bitch, the HER2 overexpression in canine mammary tumors is still controversial and the prognostic value remains uncertain. Thus, we aimed to verify the HER2 expression in canine mammary carcinomas and relate it to the type and histological grade, lymph node metastasis and clinical staging.Materials, Methods & Results: Ninety bitches diagnosed with mammary carcinoma were included in this study. The inclusion criteria were bitches with complete clinical examination, thoracic radiographic examination and submitted unilateral or bilateral mastectomy. Ninety-nine samples of mammary carcinoma were used and the fragments of tumor and regional lymph nodes were fixed in 10% neutral formalin for histopathological and immunohistochemistry analysis. The lesions were evaluated by two pathologists and classified according to the type and histological grade. HER2 expression was performed by semi-quantitative analysis of the slides according to the HerceptTestTM (Dako) recommended score. Simple carcinomas were the most frequent (51.51%) followed by complex carcinomas (46.47%) and in situ carcinoma (2.02%). The histologica
ABSTRACT
Background: The human epidermal growth factor type 2 (HER2) receptor is a membrane glycoprotein tyrosine kinase. In woman, HER2 expression is diagnosed in 30% of breast carcinomas and it is associated with a worse prognosis, higher rate of recurrence and mortality. In the bitch, the HER2 overexpression in canine mammary tumors is still controversial and the prognostic value remains uncertain. Thus, we aimed to verify the HER2 expression in canine mammary carcinomas and relate it to the type and histological grade, lymph node metastasis and clinical staging.Materials, Methods & Results: Ninety bitches diagnosed with mammary carcinoma were included in this study. The inclusion criteria were bitches with complete clinical examination, thoracic radiographic examination and submitted unilateral or bilateral mastectomy. Ninety-nine samples of mammary carcinoma were used and the fragments of tumor and regional lymph nodes were fixed in 10% neutral formalin for histopathological and immunohistochemistry analysis. The lesions were evaluated by two pathologists and classified according to the type and histological grade. HER2 expression was performed by semi-quantitative analysis of the slides according to the HerceptTestTM (Dako) recommended score. Simple carcinomas were the most frequent (51.51%) followed by complex carcinomas (46.47%) and in situ carcinoma (2.02%). The histologica
ABSTRACT
Background: The human epidermal growth factor type 2 (HER2) receptor is a membrane glycoprotein tyrosine kinase. In woman, HER2 expression is diagnosed in 30% of breast carcinomas and it is associated with a worse prognosis, higher rate of recurrence and mortality. In the bitch, the HER2 overexpression in canine mammary tumors is still controversial and the prognostic value remains uncertain. Thus, we aimed to verify the HER2 expression in canine mammary carcinomas and relate it to the type and histological grade, lymph node metastasis and clinical staging.Materials, Methods & Results: Ninety bitches diagnosed with mammary carcinoma were included in this study. The inclusion criteria were bitches with complete clinical examination, thoracic radiographic examination and submitted unilateral or bilateral mastectomy. Ninety-nine samples of mammary carcinoma were used and the fragments of tumor and regional lymph nodes were fixed in 10% neutral formalin for histopathological and immunohistochemistry analysis. The lesions were evaluated by two pathologists and classified according to the type and histological grade. HER2 expression was performed by semi-quantitative analysis of the slides according to the HerceptTestTM (Dako) recommended score. Simple carcinomas were the most frequent (51.51%) followed by complex carcinomas (46.47%) and in situ carcinoma (2.02%). The histologica
ABSTRACT
Background: The human epidermal growth factor type 2 (HER2) receptor is a membrane glycoprotein tyrosine kinase. In woman, HER2 expression is diagnosed in 30% of breast carcinomas and it is associated with a worse prognosis, higher rate of recurrence and mortality. In the bitch, the HER2 overexpression in canine mammary tumors is still controversial and the prognostic value remains uncertain. Thus, we aimed to verify the HER2 expression in canine mammary carcinomas and relate it to the type and histological grade, lymph node metastasis and clinical staging.Materials, Methods & Results: Ninety bitches diagnosed with mammary carcinoma were included in this study. The inclusion criteria were bitches with complete clinical examination, thoracic radiographic examination and submitted unilateral or bilateral mastectomy. Ninety-nine samples of mammary carcinoma were used and the fragments of tumor and regional lymph nodes were fixed in 10% neutral formalin for histopathological and immunohistochemistry analysis. The lesions were evaluated by two pathologists and classified according to the type and histological grade. HER2 expression was performed by semi-quantitative analysis of the slides according to the HerceptTestTM (Dako) recommended score. Simple carcinomas were the most frequent (51.51%) followed by complex carcinomas (46.47%) and in situ carcinoma (2.02%). The histologica
ABSTRACT
Background: The human epidermal growth factor type 2 (HER2) receptor is a membrane glycoprotein tyrosine kinase. In woman, HER2 expression is diagnosed in 30% of breast carcinomas and it is associated with a worse prognosis, higher rate of recurrence and mortality. In the bitch, the HER2 overexpression in canine mammary tumors is still controversial and the prognostic value remains uncertain. Thus, we aimed to verify the HER2 expression in canine mammary carcinomas and relate it to the type and histological grade, lymph node metastasis and clinical staging.Materials, Methods & Results: Ninety bitches diagnosed with mammary carcinoma were included in this study. The inclusion criteria were bitches with complete clinical examination, thoracic radiographic examination and submitted unilateral or bilateral mastectomy. Ninety-nine samples of mammary carcinoma were used and the fragments of tumor and regional lymph nodes were fixed in 10% neutral formalin for histopathological and immunohistochemistry analysis. The lesions were evaluated by two pathologists and classified according to the type and histological grade. HER2 expression was performed by semi-quantitative analysis of the slides according to the HerceptTestTM (Dako) recommended score. Simple carcinomas were the most frequent (51.51%) followed by complex carcinomas (46.47%) and in situ carcinoma (2.02%). The histologica
ABSTRACT
Background: The human epidermal growth factor type 2 (HER2) receptor is a membrane glycoprotein tyrosine kinase. In woman, HER2 expression is diagnosed in 30% of breast carcinomas and it is associated with a worse prognosis, higher rate of recurrence and mortality. In the bitch, the HER2 overexpression in canine mammary tumors is still controversial and the prognostic value remains uncertain. Thus, we aimed to verify the HER2 expression in canine mammary carcinomas and relate it to the type and histological grade, lymph node metastasis and clinical staging.Materials, Methods & Results: Ninety bitches diagnosed with mammary carcinoma were included in this study. The inclusion criteria were bitches with complete clinical examination, thoracic radiographic examination and submitted unilateral or bilateral mastectomy. Ninety-nine samples of mammary carcinoma were used and the fragments of tumor and regional lymph nodes were fixed in 10% neutral formalin for histopathological and immunohistochemistry analysis. The lesions were evaluated by two pathologists and classified according to the type and histological grade. HER2 expression was performed by semi-quantitative analysis of the slides according to the HerceptTestTM (Dako) recommended score. Simple carcinomas were the most frequent (51.51%) followed by complex carcinomas (46.47%) and in situ carcinoma (2.02%). The histologica
ABSTRACT
An experiment was conducted to evaluate the effects of organic acids, antibiotic, probiotic and their combination on performance, carcass yield, and pH of some parts of crop, duodenum and ceca, and of the diets of broiler chickens. Also, the experiment aimed to verify the probiotic sensibility to the antibiotic and the coccidiostatic utilized. Fourteen hundred and forty one-day-old male chicks, Hubbard, were randomly distributed in a 3 x 3 factorial design: additives in the diet (without antibiotic, avoparcin, and probiotic composed by Streptococcus faecium, Lactobacillus acidophilus and Saccharomyces cerevisiae) and organic acids in the diet (without organic acids, fumaric acid, and propionic+formic acid), totaling nine treatments with four replicates of 40 birds each. It was verified that the microorganisms Streptococcus faecium and Lactobacillus acidophilus were sensible to avoparcin in the concentration wich was employed in the diets. However, the presence of sodic monensine did not inhibit the growth, in vitro, of the probiotics microorganisms. Organic acids, antibiotic, probiotic or their combinations did not affect the performance, carcass yield, and the pH of the crop, duodenum and cecum in relation to the control diet. Nevertheless, the fumaric acid promoted a reduction in the pH of the diet, and might contribute to an inhibition of the growth of undesirable microorga
Desenvolveu-se um experimento para avaliar os efeitos de ácidos orgânicos, antibiótico, probiótico e suas combinações sobre o desempenho, rendimento de carcaça e pH de papo, duodeno e ceco e das rações de frangos de corte. Além disso, o experimento objetivou verificar a sensibilidade do probiótico ao antibiótico e ao agente anticoccidiano utilizados. Empregaram-se 1.440 pintos com um dia de idade, machos, da linhagem Hubbard, distribuídos em um delineamento inteiramente casualizado em esquema fatorial 3 x 3, com os fatores: aditivos na ração (sem antibiótico, avoparcina e probiótico composto por Streptococcus faecium, Lactobacillus acidophilus e Saccharomyces cerevisiae) e ácidos orgânicos na ração (sem ácido orgânico, ácido fumárico e ácido propiônico+fórmico), totalizando nove tratamentos com quatro repetições de quarenta aves cada. Observou-se que os microorganismos Streptococcus faecium e Lactobacillus acidophilus foram sensíveis à avoparcina na concentração em que se empregou nas rações. No entanto, a presença de monensina sódica (anticoccidiano) não inibiu o crescimento, in vitro, dos microrganismos presentes no probiótico. Os ácidos orgânicos, o antibiótico, o probiótico ou suas combinações não alteraram o desempenho, rendimento de carcaça e o pH do papo, duodeno e ceco em relação à dieta-controle. Contudo, o ácido fumárico promoveu redução do pH da ração, podendo contri
ABSTRACT
An experiment was conducted to evaluate the effect of different antibiotics, probiotics and their combination on performance and carcass yield of broiler chickens. Also, the experiment aimed to verify the probiotics sensibility to the antibiotics and the coccidiostatic utilized. Fourteen hundred and forty one-day-old male chicks, Hubbard, were randomly distributed in a 3 x 3 factorial design: antibiotic in the diet (without antibiotic, virginiamicin, and avilamicin) and probiotic in the diet (without probiotic, and probiotics A and B), totaling nine treatments with four replicates of 40 birds each. The probiotics were: A) Streptococcus faecium, Lactobacillus acidophilus and Saccharomyces cerevisiae; B) Bacillus subtilis. It was verified that the tested probiotics can be used together with sodic monensine (coccidiostatic) and the avilamicin (growth promoter). However, the presence of virginiamicin can impair the probiotics viability, since the probiotics microorganisms were sensible to virginiamicin (observed in vitro). There was no significant interaction between antibiotic and probiotic for the evaluated variables. Mortality was reduced by the use of probiotics A or B, whereas the use of avilamicin increased mortality from 1 to 42 days of age. The other performance, carcass and parts yield characteristics were not influenced by the administration of probiotics, antibiotics or
Desenvolveu-se um experimento para avaliar o efeito de diferentes antibióticos, probióticos e suas combinações sobre o desempenho e rendimento de carcaça de frangos de corte e também para verificar a sensibilidade dos probióticos aos antibióticos e ao agente anticoccidiano utilizados. Empregaram-se 1.440 pintos com um dia de idade, machos, da linhagem Hubbard, distribuídos em um delineamento inteiramente casualizado em esquema fatorial 3 x 3, com os fatores antibióticos na ração (sem antibiótico, virginiamicina e avilamicina) e probióticos na ração (sem probiótico, probiótico A e B), totalizando nove tratamentos com quatro repetições de quarenta aves cada. Os probióticos foram: A) Streptococcus faecium, Lactobacillus acidophilus e Saccharomyces cerevisiae; B) Bacillus subtilis. Verificou-se que os probióticos testados podem ser empregados conjuntamente com a monensina sódica (agente anticoccidiano) e a avilamicina (promotor de crescimento). No entanto, a presença de virginiamicina pode comprometer a viabilidade dos probióticos, dada a sensibilidade, in vitro, dos microrganismos presentes nos probióticos. Não houve interação entre probióticos e antibióticos para as variáveis avaliadas. Houve redução da mortalidade quando se utilizaram os probióticos A ou B e aumento na presença de avilamicina para o período de 1 a 42 dias de idade. As demais variáveis de desempenho e o rendiment
ABSTRACT
An experiment was conducted to evaluate the effect of different antibiotics, probiotics and their combination on performance and carcass yield of broiler chickens. Also, the experiment aimed to verify the probiotics sensibility to the antibiotics and the coccidiostatic utilized. Fourteen hundred and forty one-day-old male chicks, Hubbard, were randomly distributed in a 3 x 3 factorial design: antibiotic in the diet (without antibiotic, virginiamicin, and avilamicin) and probiotic in the diet (without probiotic, and probiotics A and B), totaling nine treatments with four replicates of 40 birds each. The probiotics were: A) Streptococcus faecium, Lactobacillus acidophilus and Saccharomyces cerevisiae; B) Bacillus subtilis. It was verified that the tested probiotics can be used together with sodic monensine (coccidiostatic) and the avilamicin (growth promoter). However, the presence of virginiamicin can impair the probiotics viability, since the probiotics microorganisms were sensible to virginiamicin (observed in vitro). There was no significant interaction between antibiotic and probiotic for the evaluated variables. Mortality was reduced by the use of probiotics A or B, whereas the use of avilamicin increased mortality from 1 to 42 days of age. The other performance, carcass and parts yield characteristics were not influenced by the administration of probiotics, antibiotics or
Desenvolveu-se um experimento para avaliar o efeito de diferentes antibióticos, probióticos e suas combinações sobre o desempenho e rendimento de carcaça de frangos de corte e também para verificar a sensibilidade dos probióticos aos antibióticos e ao agente anticoccidiano utilizados. Empregaram-se 1.440 pintos com um dia de idade, machos, da linhagem Hubbard, distribuídos em um delineamento inteiramente casualizado em esquema fatorial 3 x 3, com os fatores antibióticos na ração (sem antibiótico, virginiamicina e avilamicina) e probióticos na ração (sem probiótico, probiótico A e B), totalizando nove tratamentos com quatro repetições de quarenta aves cada. Os probióticos foram: A) Streptococcus faecium, Lactobacillus acidophilus e Saccharomyces cerevisiae; B) Bacillus subtilis. Verificou-se que os probióticos testados podem ser empregados conjuntamente com a monensina sódica (agente anticoccidiano) e a avilamicina (promotor de crescimento). No entanto, a presença de virginiamicina pode comprometer a viabilidade dos probióticos, dada a sensibilidade, in vitro, dos microrganismos presentes nos probióticos. Não houve interação entre probióticos e antibióticos para as variáveis avaliadas. Houve redução da mortalidade quando se utilizaram os probióticos A ou B e aumento na presença de avilamicina para o período de 1 a 42 dias de idade. As demais variáveis de desempenho e o rendiment
ABSTRACT
An experiment was conducted to evaluate the effects of organic acids, antibiotic, probiotic and their combination on performance, carcass yield, and pH of some parts of crop, duodenum and ceca, and of the diets of broiler chickens. Also, the experiment aimed to verify the probiotic sensibility to the antibiotic and the coccidiostatic utilized. Fourteen hundred and forty one-day-old male chicks, Hubbard, were randomly distributed in a 3 x 3 factorial design: additives in the diet (without antibiotic, avoparcin, and probiotic composed by Streptococcus faecium, Lactobacillus acidophilus and Saccharomyces cerevisiae) and organic acids in the diet (without organic acids, fumaric acid, and propionic+formic acid), totaling nine treatments with four replicates of 40 birds each. It was verified that the microorganisms Streptococcus faecium and Lactobacillus acidophilus were sensible to avoparcin in the concentration wich was employed in the diets. However, the presence of sodic monensine did not inhibit the growth, in vitro, of the probiotics microorganisms. Organic acids, antibiotic, probiotic or their combinations did not affect the performance, carcass yield, and the pH of the crop, duodenum and cecum in relation to the control diet. Nevertheless, the fumaric acid promoted a reduction in the pH of the diet, and might contribute to an inhibition of the growth of undesirable microorga
Desenvolveu-se um experimento para avaliar os efeitos de ácidos orgânicos, antibiótico, probiótico e suas combinações sobre o desempenho, rendimento de carcaça e pH de papo, duodeno e ceco e das rações de frangos de corte. Além disso, o experimento objetivou verificar a sensibilidade do probiótico ao antibiótico e ao agente anticoccidiano utilizados. Empregaram-se 1.440 pintos com um dia de idade, machos, da linhagem Hubbard, distribuídos em um delineamento inteiramente casualizado em esquema fatorial 3 x 3, com os fatores: aditivos na ração (sem antibiótico, avoparcina e probiótico composto por Streptococcus faecium, Lactobacillus acidophilus e Saccharomyces cerevisiae) e ácidos orgânicos na ração (sem ácido orgânico, ácido fumárico e ácido propiônico+fórmico), totalizando nove tratamentos com quatro repetições de quarenta aves cada. Observou-se que os microorganismos Streptococcus faecium e Lactobacillus acidophilus foram sensíveis à avoparcina na concentração em que se empregou nas rações. No entanto, a presença de monensina sódica (anticoccidiano) não inibiu o crescimento, in vitro, dos microrganismos presentes no probiótico. Os ácidos orgânicos, o antibiótico, o probiótico ou suas combinações não alteraram o desempenho, rendimento de carcaça e o pH do papo, duodeno e ceco em relação à dieta-controle. Contudo, o ácido fumárico promoveu redução do pH da ração, podendo contri
ABSTRACT
Correção cirúrgica da ruptura de pênis em bovinos
ABSTRACT
Correção cirúrgica da ruptura de pênis em bovinos