ABSTRACT
PURPOSE: To identify clinical and biologic variables with significant impact on survival in patients with carcinomas of an unknown primary site (CUP) and to develop a simple prognostic model. PATIENTS AND METHODS: In this retrospective study, univariate and multivariate prognostic factors analyses were conducted in a population of 100 patients with CUP. Patients with features requiring well defined treatments had previously been excluded. RESULTS: Overall survival (OS) was significantly related to the following pretreatment adverse prognostic clinical factors: a poor performance status (2 or 3), weight loss more than 10% in the last six months, the presence of liver metastases and more than two metastatic sites. Two biological parameters predicted a significantly shorter survival: elevated serum levels of alkaline phosphatase and of lactate dehydrogenase. In the multivariate analysis, only two independent adverse prognostic parameters were retained: a poor performance status and the presence of liver metastases. We developed a prognostic model for OS based on the following subgroups: good prognosis (PS 0 or 1 and absence of liver metastases), intermediate prognosis (PS> or =2 or presence of liver metastases) and poor prognosis (PS> or =2 or presence of liver metastases). Median OS for the three groups was 10.8, 4 and 1.9 months respectively, p<0.0001. CONCLUSION: A simple prognostic model using performance status and presence of liver metastases was developed. It allowed the assignment of patients into three subgroups with different outcomes. Treatment strategies could be adapted for each subgroup. We think that this prognostic model could be useful and should be validated in other patient series.
Subject(s)
Carcinoma/diagnosis , Carcinoma/secondary , Neoplasms, Unknown Primary/diagnosis , Neoplasms, Unknown Primary/mortality , Adult , Aged , Aged, 80 and over , Biomarkers, Tumor/blood , Carcinoma/mortality , Female , Humans , Male , Models, Biological , Models, Statistical , Multivariate Analysis , Prognosis , Retrospective Studies , Serum Albumin/metabolism , Survival AnalysisABSTRACT
PURPOSE: To identify clinical and biologic variables with significant impact on survival in patients with carcinomas of an unknown primary site (CUP) and to develop a simple prognostic model. PATIENTS AND METHODS: In this retrospective study, univariate and multivariate prognostic factors analyses were conducted in a population of 100 patients with CUP. Patients with features requiring well defined treatments had previously been excluded. RESULTS: Overall survival (OS) was significantly related to the following pretreatment adverse prognostic clinical factors: a poor performance status (2 or 3), weight loss more than 10% in the last six months, the presence of liver metastases and more than two metastatic sites. Two biological parameters predicted a significantly shorter survival: elevated serum levels of alkaline phosphatase and of lactate dehydrogenase. In the multivariate analysis, only two independent adverse prognostic parameters were retained: a poor performance status and the presence of liver metastases. We developed a prognostic model for OS based on the following subgroups: good prognosis (PS 0 or 1 and absence of liver metastases), intermediate prognosis (PS> or =2 or presence of liver metastases) and poor prognosis (PS> or =2 or presence of liver metastases). Median OS for the three groups was 10.8, 4 and 1.9 months respectively, p<0.0001. CONCLUSION: A simple prognostic model using performance status and presence of liver metastases was developed. It allowed the assignment of patients into three subgroups with different outcomes. Treatment strategies could be adapted for each subgroup. We think that this prognostic model could be useful and should be validated in other patient series (AU)
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Carcinoma/diagnosis , Carcinoma/mortality , Carcinoma/secondary , Neoplasms, Unknown Primary/diagnosis , Neoplasms, Unknown Primary/mortality , Biomarkers, Tumor/analysis , Biomarkers, Tumor/blood , Models, Biological , Models, Statistical , Multivariate Analysis , Prognosis , Retrospective Studies , Serum Albumin/metabolism , Survival AnalysisABSTRACT
Malignant mesothelioma is an insidious neoplasm arising from the mesotelial surfaces, of the pleural and peritoneal cavities, the tunica vaginalis, or the pericardium. The predominant cause is inhalation exposure to asbestos. We present a rare case of primary malignant mesothelioma of the peritoneum in a 64 year old man without history of inhalation exposure to asbestos. The initial symptoms were constitutional syndrome and right pleural effusion. Positron emission tomography combined with computed tomography (PET/TC) was useful for a supporting diagnosis and to determine the extension. The patient received treatment with systemic palliative chemotherapy, cisplatin-pemetrexed. After three cycles, partial response was observed, but the evolution was fatal due to secondary toxicity of chemotherapy.
Subject(s)
Mesothelioma/diagnosis , Peritoneal Neoplasms/diagnosis , Asbestos , Fatal Outcome , Humans , Male , Mesothelioma/drug therapy , Middle Aged , Peritoneal Neoplasms/drug therapyABSTRACT
El mesotelioma maligno es un tumor insidioso que se origina de las superficies mesoteliales de las cavidades pleurales y peritoneales, la túnica vaginal o el pericardio. La principal causa relacionada es la exposición al asbesto. Presentamos el caso de un mesotelioma maligno peritoneal en un varón de 64 años, sin hábitos tóxicos ni exposición al asbesto, que debutó con síndrome constitucional y derrame pleural derecho. La tomografía por emisión de positrones combinada con tomografía axial computerizada (PET-TAC) fue de especial utilidad demostrando un intenso hipermetabolismo en peritoneo con extensión a pared torácica. El paciente inició tratamiento con quimioterapia sistémica, esquema cisplatino-pemetrexed, alcanzando una respuesta parcial tras los 3 ciclos pero con una evolución tórpida secundaria a toxicidad del tratamiento citostático
Malignant mesothelioma is an insidious neoplasm arising from the mesotelial surfaces, of the pleural and peritoneal cavities, the tunica vaginalis, or the pericardium. The predominant cause is inhalation exposure to asbestos. We present a rare case of primary malignant mesothelioma of the peritoneum in a 64 year old man without history of inhalation exposure to asbestos. The initial symptoms were constitutional syndrome and right pleural effusion. Positron emission tomography combined with computed tomography (PET/TC) was useful for a supporting diagnosis and to determine the extension. The patient received treatment with systemic palliative chemotherapy, cisplatin-pemetrexed. After three cycles, partial response was observed, but the evolution was fatal due to secondary toxicity of chemotherapy