1.
Dalton Trans
; 39(12): 3065-71, 2010 Mar 28.
Article
in English
| MEDLINE
| ID: mdl-20221541
ABSTRACT
In search for peptidic [FeFe] hydrogenase mimics, the cyclic disulfide Sandostatin (octreotide) was allowed to react with Fe(3)(CO)(12). An octreotide-Fe(2)(CO)(6) complex was isolated and characterized spectroscopically as well as by elemental and thermochemical analysis. The complex catalyzes the electrochemical reduction of H(+) to H(2). It is suggested by radioligand binding assays that the complex retains much of the binding affinity for the somatostatin hsst(1-5) receptors of octreotide.
Subject(s)
Antineoplastic Agents, Hormonal/chemistry , Carbonates/chemistry , Ferric Compounds/chemistry , Octreotide/chemistry , Bacterial Proteins/chemistry , Catalytic Domain , Electrochemical Techniques , Humans , Hydrogenase/chemistry , Iron-Sulfur Proteins/chemistry , Molecular Structure , Somatostatin/chemistry
2.
Angew Chem Int Ed Engl
; 42(13): 1540-3, 2003 Apr 04.
Article
in English
| MEDLINE
| ID: mdl-12698495