ABSTRACT
Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma.
Subject(s)
Antigens, Nuclear/genetics , DNA-Binding Proteins/genetics , Hypoxia/genetics , Uterine Cervical Neoplasms/genetics , Adult , Aged , Aged, 80 and over , Down-Regulation , Female , Humans , Immunoenzyme Techniques , Ku Autoantigen , Middle Aged , Prospective Studies , Uterine Cervical Neoplasms/radiotherapyABSTRACT
OBJECTIVE: To assess the expression of MVP in cervix carcinoma patients treated by radiochemotherapy, its relation to clinical and pathologic prognostic factors and its role in predicting clinical outcome. In addition the relation to IGF-1R expression in this cohort of patients will be explored. MATERIALS AND METHODS: Sixty consecutive patients suffering from localized cervix carcinoma were prospectively included in this study from July 1999 to December 2003. Follow-up was closed in November 2007. Patients were staged following the TNM classification. All patients received pelvic radiation (45-64.80 Gy in 1.8-2 Gy fractions) followed brachytherapy and concomitant cisplatin at 40 mg/m(2)/week doses. MVP expression was studied by immunohistochemistry in paraffin-embedded tumour tissue. RESULTS: MVP was expressed in 58 patients (96.7%) and no relation was found with clinicopathological variables. High MVP expression was related to high IGF1-R expression (p=0.023). Complete response after treatment was observed in 50 patients (83.3%). Clinical stage of the disease and clinical response to radiochemotherapy were the most important prognostic factors related to survival. High MVP and IGF-1R tumour expression was strongly related to poor local and regional disease-free survival (p=0.006), distant disease-free survival (p=0.050), disease-free survival (p=0.006), and cause-specific survival (p=0.007) in patients achieving a complete response. CONCLUSION: MVP and IGF-1R expression were related in clinical cervical tumours and confer reduced long-term local control in patients who achieved clinical complete response to radiochemotherapy.
Subject(s)
Receptor, IGF Type 1/biosynthesis , Uterine Cervical Neoplasms/metabolism , Uterine Cervical Neoplasms/therapy , Vault Ribonucleoprotein Particles/biosynthesis , Cohort Studies , Combined Modality Therapy , Disease-Free Survival , Female , Humans , Immunohistochemistry , Middle Aged , Prospective Studies , Treatment Outcome , Uterine Cervical Neoplasms/drug therapy , Uterine Cervical Neoplasms/radiotherapySubject(s)
Alcoholism/complications , Ear Diseases/parasitology , Myiasis/complications , Nose Diseases/parasitology , Animals , Ear Canal/parasitology , Ear Diseases/diagnosis , Ear Diseases/therapy , Humans , Larva , Male , Middle Aged , Myiasis/diagnosis , Myiasis/therapy , Nasal Cavity/parasitology , Nose Diseases/diagnosis , Nose Diseases/therapy , Treatment OutcomeABSTRACT
No disponible
Subject(s)
Male , Middle Aged , Humans , Larva/pathogenicity , Ear Diseases/parasitology , Myiasis/microbiology , Proteus mirabilis/isolation & purification , Alcoholism/complications , Ill-Housed PersonsSubject(s)
Pneumonia, Bacterial/diagnosis , Staphylococcal Infections/diagnosis , Staphylococcus/isolation & purification , Aged , Bronchoalveolar Lavage Fluid/microbiology , Cardiovascular Diseases/complications , Coagulase/analysis , Community-Acquired Infections/diagnosis , Community-Acquired Infections/microbiology , Diabetes Mellitus, Type 2/complications , Disease Susceptibility , Female , Humans , Morocco/ethnology , Pneumonia, Bacterial/complications , Pneumonia, Bacterial/microbiology , Spain , Sputum/microbiology , Staphylococcal Infections/complications , Staphylococcal Infections/microbiology , Staphylococcus/classification , Staphylococcus/enzymologyABSTRACT
No disponible
